An outbreak of Aseptic Meningitis due to echovirus type 30 in two cities of Turkey

Ozkaya, E.; Hızel, Kenan; Uysal, Gülnar; Akman, Sema; Terzioğlu, Serdar Gökay; Kuyucu, Necdet

doi:10.1023/a:1025334116364

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…Reintjes et al [15] reported the echovirus 30 meningitis outbreak in Germany in 1997. In Turkey, we detected an echovirus 30 aseptic meningitis outbreak during the summer of 1999 [12,13]. Also in Belgium, Spain and France echovirus 30 was the most frequently isolated aseptic meningitis agent in year 2000 [7,8,22].…”

Section: Discussionmentioning

confidence: 80%

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Enteroviral meningitis in children in Turkey

Şensoy

Sel

Ozkaya³

et al. 2009

Open Medicine

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AbstractIn the indexed medical literature, there have been a very limited number of studies to investigate the epidemiologic and clinical features of enteroviral meningitis in Turkey. The aim of the present retrospective study is to update the actual situation to recognize the spectrum and magnitude of this important clinical entity. Between June 1999 and December 2004, 612 cases of aseptic meningitis were followed up at our hospital. Enteroviral meningitis was defined by isolation of enteroviruses from cerebrospinal fluid (CSF) and/or stool samples. Mumps virus was detected in 310 cases (50.7%) and enteroviruses were the etiologic agents in 104 (17%) of the patients with aseptic meningitis. Most of the enteroviral meningitis cases (36 cases, 34.6%) were diagnosed in August and 70 (67.3%) of them were male. The mean age was 5.6 ± 3.4 years. The most common initial symptoms were fever (81.7%), vomiting (77.9%) and headache (57.7%). In the physical examination, 46.2% of the cases had neck stiffness and 38.5% had pharyngitis. Echovirus 30 was the most frequently (38 cases, 36.5%) isolated enterovirus with peaks in 1999, 2002 and 2004. The other frequently isolated enteroviruses were Coxsackie virus type B (17 cases, 16.3%), echovirus 6 (11 cases, 10.6%), echovirus 11 (6 cases, 5.8%), and echovirus 13 (4 cases, 3.8 %). Mean hospitalization time was 6.2 ± 2.4 days. All patients recovered without any sequelae. Enteroviruses have an important role in childhood aseptic meningitis cases in Turkey too, and the predominant serotypes vary according to years.

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Section: Discussionmentioning

confidence: 80%

“…In the summer season of 1999, we detected an echovirus 30 outbreak of aseptic meningitis in Turkey [12,13]. It was the first report about enteroviral meningitis from Turkey.…”

Section: Introductionmentioning

confidence: 90%

Enteroviral meningitis in children in Turkey

Şensoy

Sel

Ozkaya³

et al. 2009

Open Medicine

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“…In Spain a study reported cases associated to viral meningitis, during the period from 1988 to 1997 with a high incidence of HEV and the predominance of EV-30 (90%) among non-polio serotype (36). This serotype was responsible for aseptic meningitis epidemics in Japan in 1991 and 1997 (39, 40), Switzerland in 1996 (13), Canada in 1998 (4), Romania in 1999 (5), and more recently published, in Turkey in 1999 (26), France in 2000 (7), Belgium in 2000 (35) and Brazil in 2003 (16,2). Our retrospective study agrees with literature data.…”

Section: Discussionmentioning

confidence: 97%

Aseptic meningitis by echovirus 30 in São Paulo state, Brazil

Machado¹,

Ferreira²,

Carmona³

et al. 2007

Braz. J. Microbiol.

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The objective of this study was to identify and characterize the immunological and molecular aspects of Human Enterovirus (HEV) associated with aseptic meningitis cases in São Paulo State, Brazil. Clinical samples (cerebrospinal fluid CSF, stool and sera) were analyzed from 21 viral meningitis suspected cases collected in the period from 1998 to 1999. The isolated virus were identified as belonging to Enterovirus genus and specifically to echovirus serotype 30 (EV-30), using immunological techniques as Indirect Immunofluorescense Assay (IFA) and Neutralization (Nt) and by molecular technique of Reverse Transcription Polymerase Chain Reaction (RT-PCR) directed to the 5'NTR and VP1 regions of viral genome. The results obtained contributed with to the surveillance system of São Paulo State and they are important due to a shortage of epidemiological data about the circulation of EV-30 associated to aseptic meningitis in this region of the world.

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“…Özellikle sıcak hava ve iklim koşullarında EV fekal-oral yayılımı artar. EV menenjiti açısından en duyarlı grup sütçocukları ve küçük çocuklardır (8,22) . Çalışmamızda da, EV %25 ile en sık etken olarak yer aldı.…”

Section: Discussionunclassified