An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs

Lautz, L.S.; Nebbia, Carlo; Hoeks, Selwyn; Oldenkamp, Rik; Hendriks, A. Jan; Ragas, A.M.J.; Dorne, Jean‐Lou

doi:10.1016/j.envint.2020.105488

Cited by 36 publications

(34 citation statements)

References 114 publications

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“…This value was based on data from 5 different studies with 54 animals (Alexander et al., 1973 ; Hales, 1973b , 1973c ; Hales et al., 1976 ; Hales & Fawcett, 1993 ). This value is comparable to the value of 2% for dogs and rats, and 3.3% for mice (Brown et al., 1997 ), and is slightly higher than 1.9% for sheep reported in another review paper (Lautz, Nebbia, et al., 2020 ). This parameter value is much higher in humans, with a value of 11.4% (Brown et al., 1997 ).…”

Section: Resultssupporting

confidence: 77%

“…An explanation for this could be the lack of robust computational tools and summarized or standardized physiological parameters for food‐producing animals. However, there were at least five papers published in 2017 for the application of PBPK modeling in food safety assessment (Lautz et al., 2019 ), and at least 9 papers (Lautz, Hoeks, et al., 2020 ; Lautz, Nebbia, et al., 2020 ; Li, Cheng, et al., 2019 ; Li, Mainquist‐Whigham, et al., 2019 ; Méda et al., 2020 ; Tebby et al., 2019 ; Xu et al., 2019 ; Yang et al., 2019 ; Zeng et al., 2019 ) published in this field during 2019 and 2020. The increasing development and application of PBPK modeling in the food safety area requires a standardized repository of physiological parameters in food‐producing animals.…”

Section: Discussionmentioning

confidence: 99%

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Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food‐producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in tables. Equations describing the growth curves of sheep and goats are presented in figures. When data are sufficient, parameter values are reported for different ages or production classes of sheep, including fetal sheep, lambs, and market‐age sheep (mature sheep). These data provide a reference database for developing standardized PBPK models to predict drug withdrawal intervals in sheep and goats, and also provide a basis for extrapolating PBPK models from major species such as cattle to minor species such as sheep and goats.

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Section: Resultssupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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show abstract

“… a GI Tract: Values in the present study include blood flow to proventriculus, ventriculus, and intestines; values from Lautz et al. ( 2020 ) include only intestines. b Liver: Value here represents blood flow in the hepatic artery.…”

Section: Resultsmentioning

confidence: 99%

“…Each parameter value is compared to values from published reports of physiological parameters for PBPK modeling in other species, including mice, rats, dogs, humans, cattle, and swine (Brown et al., 1997 ; Davies & Morris, 1993 ; Lin et al., 2020 ; Upton, 2008 ), as well as currently available PBPK models for chickens (Cortright et al., 2009 ; Henri et al., 2017 ; MacLachlan, 2010 ; Yang et al., 2014 , 2015 ; Zeng et al., 2019 ). Tables 24 and 25 present overall comparisons of our compiled data with data from a recently published PBPK model in domestic chickens (Lautz et al., 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part II: Chicken and turkey

Wang

Tell

et al. 2020

Vet Pharm & Therapeutics

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Physiologically based pharmacokinetic (PBPK) models are growing in popularity due to human food safety concerns and for estimating drug residue distribution and estimating withdrawal intervals for veterinary products originating from livestock species. This paper focuses on the physiological and anatomical data, including cardiac output, organ weight, and blood flow values, needed for PBPK modeling applications for avian species commonly consumed in the poultry market. Experimental and field studies from 1940 to 2019 for broiler chickens (1–70 days old, 40 g ‐ 3.2 kg), laying hens (4–15 months old, 1.1–2.0 kg), and turkeys (1 day−14 months old, 60 g −12.7 kg) were searched systematically using PubMed, Google Scholar, ProQuest, and ScienceDirect for data collection in 2019 and 2020. Relevant data were extracted from the literature with mean and standard deviation (SD) being calculated and compiled in tables of relative organ weights (% of body weight) and relative blood flows (% of cardiac output). Trends of organ or tissue weight growth during different life stages were calculated when sufficient data were available. These compiled data sets facilitate future PBPK model development and applications, especially in estimating chemical residue concentrations in edible tissues to calculate food safety withdrawal intervals for poultry.

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“… PBK models for farm animals (chicken, swine, sheep, cattle_b and cattle_d) (Lautz et al, 2020a).  Generic PBK model for human, beagle, rat, mouse and rabbit (Lautz et al, 2020b).…”

Section: Toxicokinetic Module 2221 Modelsmentioning

confidence: 99%

A Web‐based open source tool for Toxicokinetic and Toxicodynamic modelling

Bossier¹,

Chau²,

Ndour³

et al. 2020

EFSA Supporting Publications

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This report presents the implementation of a web tool for the extension of exposure-and toxicokinetictoxicodynamic analysis that has been developed under a specific EFSA request to Open Analytics under the framework agreement (OC/EFSA/AMU/2015/02). An open source software has been developed in R as a WEB-based tool including different components for the modelling of toxicokinetic (TK) and toxicodynamic (TD) processes within a structured workflow. The workflow provides the steps to perform such TK-TD modelling for single chemicals in the human health, animal health and ecological risk assessment. The web-based tool results in the implementation of four modules: (1) Chemical specific modules, (2) Physiological and life cycle trait modules, (3) Toxicokinetic module, and (4) Toxicodynamic module.

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An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs

Cited by 36 publications

References 114 publications

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part II: Chicken and turkey

A Web‐based open source tool for Toxicokinetic and Toxicodynamic modelling

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