An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection

Abstract

There are numerous barriers to achieving effective intraocular drug administration, including the mucus layer protecting the ocular surface. For this reason, antibiotic eye drops must be used multiple times per day to prevent and treat ocular infections. Frequent eye drop use is inconvenient for patients, and lack of adherence to prescribed dosing regimens limits treatment efficacy and contributes to antibiotic resistance.Here, we describe an ion-pairing approach used to create an insoluble moxifloxacinpamoate (MOX-PAM) complex for formulation into mucus-penetrating nanosuspension eye drops (MOX-PAM NS). The MOX-PAM NS provided a significant increase in ocular drug absorption, as measured by the area under the curve in cornea tissue and aqueous humor, compared to Vigamox in healthy rats. Prophylactic and treatment efficacy were evaluated in a rat model of ocular Staphylococcus aureus infection. A single drop of MOX-PAM NS was more effective than Vigamox, and completely prevented infection. Once a day dosing with MOX-PAM NS was similar, if not more effective, than three times a day dosing with Vigamox for treating Aditya Josyula and Revaz Omiadze contributed equally to this study.

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

“…The animal procedures involved were in accordance with the Association for Research in Vision and Ophthalmology Statement of Shanghai Tenth People’s Hospital. Six weeks of SD male rats were used to simulate the occurrence of BK as previously described with minor adjustments ( Josyula et al, 2021 ). After general anesthetization by chloraldurate, 0.5% proparacaine hydrochloride ophthalmic solution was performed for local anesthesia.…”

Recent approaches to combat various infections in eye

“…Treatments have traditionally centered on depressing the severity of symptoms rather than addressing the underlying etiology current research on potential remedies is highlighted, and their efficacy is discussed in fig. 5 [44,45].…”

“…Atopic dermatitis may become worse if you consume alcohol,coffee,chocolate, spicy food, hot beverages, or dairy items.Prolonged sun exposure, severe weather,and mental stress can all exacerbate this disease. Astringents, topical irritants, and a number of drugs (such as amiodarone, topical & nasal steroids,and vitamins B6 & B12) can all make symptoms worse [45,46]. As a result, refraining from using these substances is now considered the best way to cure rosacea.…”

“…Intraductal meibomian gland probing functions by physically opening the cicatrized orifices, allowing the contents to flow and stabilising the tear film.Multiple studies have demonstrated that patients' symptoms improve without major adverse effects. "Lipi flow" is a potential treatment that combines heat and mechanical stimulation of the eyelid glands to "milk" the glands and encourage the ejection of meibomian gland content [45].…”

ε‐poly‐L‐lysine‐modified polydopamine nanoparticles for targeted photothermal therapy of drug‐resistant bacterial keratitis

“…As a purulent corneal infection caused by bacteria, bacterial keratitis can lead to corneal melting, scarring, and perforation if not treated promptly and potently. 1 , 2 Conventional clinical protocol includes the topical administration of broad‐spectrum antibiotic eye drops. Whereas the development of novel antibiotics has encountered huge obstacles to keep pace with the evolution of multidrug‐resistant (MDR) bacteria.…”