An intrinsic inaccuracy of radial immunodiffusion measurements of incomplete antigens

Lietze, Arthur; Sinclair, Colin; Rowe, Albert H.

doi:10.1016/s0009-9120(70)80044-3

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…According to Lietze (6) and Mulder (7)(8), multiple precipitation, noticed in pathological samples in single radial immunodiffusion is either due to the blocking of antigenic determinants by other bound proteins, or due to the lack of antigenic determinants in the individual immunoglobulins.…”

Section: Resultsmentioning

confidence: 99%

Bound and Free Light Chains in Subacute Sclerosing Panencephalitis and Multiple Sclerosis Serum and Cerebrospinal Fluid

Bollengier¹,

Löwenthal²,

Henrotin³

1975

Clinical Chemistry and Laboratory Medicine

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The kappa-lambda light chain ratios, the presence of free light chains and the double ring formation, with antikappa and antilambda serum, in single radial immunodiffusion were investigated in serum and cerebrospinal fluid of patients with subacute sclerosing panencephalitis.Cerebrospinal fluid samples of several multiple sclerosis cases were considered simultaneously. The results obtained suggest special immunoglobulin synthesis in both diseases. Gebundene und freie leichte Ketten in Serum und Liquor cerebrospinalis bei Subakuter Sklerosierender Panenceplmlitis und Multipler SkleroseZusammenfassung: In Serum und Liquor cerebrospinalis von Patienten mit subakuter Sklerosierender Panencephalitis wurden die Verhältnisse von leichten Kappa-zu leichten Lambda-Ketten und die Doppelring-Bildung mit anti-Kappaund anti-Lambda-Serum in der einfachen radialen Immundiffusion untersucht.Liquorproben zahlreicher Fälle von Multipler Sklerose wurden ebenfalls untersucht. Die Ergebnisse sprechen für eine spezielle Imunnglobulinsynthese bei beiden Erkrankungen.

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Section: Resultsmentioning

confidence: 99%