An Insight to Oral Epithelial Dysplasia

Rastogi, Vishal; Puri, N. D.; Mishra, Satyaranjan; Arora, Swati; Kaur, Geetpriya; Yadav, L. S.

doi:10.5005/jp-journals-10001-1144

Cited by 21 publications

(17 citation statements)

References 17 publications

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“…Histopathology remains the most useful and essential investigation to detect premalignant lesions, to assess the severity of epithelial dysplasia, and to predict possible malignant transformation. 10 There are no fixed guidelines a clinicoPatHoloGic and ePideMioloGic study of cHronic wHite lesions in tHe oral Mucosa as to how much tissue should be obtained for biopsy or from which area it should be obtained in a large lesion. The common view is that biopsy should be taken from the edge of the lesion along with some adjacent normal-appearing mucosa.…”

Section: Figure 1 One Patient With a Premalignant Lesion Exhibits A Hypertrophied Variety Of Lichen Planus Over The Dorsum Of The Tongue mentioning

confidence: 99%

A Clinicopathologic and Epidemiologic Study of Chronic White Lesions in the Oral Mucosa

et al. 2017

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Invasive oral squamous cell carcinoma is often preceded by the presence of clinically identifiable premalignant changes of the oral mucosa, including white lesions. We conducted a cross-sectional, observational study to assess the clinicopathologic and epidemiologic aspects of chronic oral mucosal white lesions to determine the necessity of early biopsy in these cases. Our study population was made up of 77 patients—50 males and 27 females, aged 15 to 70 years (mean: 42.9)—who presented with white lesions persisting for at least 4 weeks. All but 3 patients underwent a biopsy; the 3 exceptions were diagnosed with smear-proven candidiasis. Patients with moderate or severe dysplasia underwent an excision biopsy. The buccal mucosa was the single most common site of white lesions, occurring in 15 patients (19.5%), although 21 patients (27.3%) exhibited a diffuse involvement of the oral mucosa. Of the 77 patients, 59 (76.6%) had concerning findings: premalignant lesions in 45 patients (58.4%) and malignant lesions in 14 (18.2%). Also, dysplasia was seen in 8 patients (10.4%), all of whom had premalignant lesions. Tobacco chewing (p = 0.008) and betel quid chewing (p = 0.029) were significantly associated with the development of premalignant and malignant lesions; a longer duration of tobacco chewing (≥10 yr) was significantly associated with a higher risk of malignant but not premalignant lesions (p = 0.031). Finally, illiteracy was a significant risk factor for premalignant and malignant lesions (p = 0.03). Our findings support the necessity of biopsy in every case. Early detection of oral carcinoma by biopsy of all oral white lesions would not only prevent patients from undergoing disfiguring surgery and chemoradiation, but it also would increase the 5-year survival rate.

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Section: Figure 1 One Patient With a Premalignant Lesion Exhibits A Hypertrophied Variety Of Lichen Planus Over The Dorsum Of The Tongue mentioning

confidence: 99%

A Clinicopathologic and Epidemiologic Study of Chronic White Lesions in the Oral Mucosa

et al. 2017

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“…WHO system which was used in our study, (2005) is based on tissue architecture and cytology and it grades dysplasia in to hyperplasia (increased cell numbers without cellular atypia), mild dysplasia (minimal architectural changes typically confined to the basal third of epithelium), moderate dysplasia (marked architectural changes seen in basal two-thirds of epithelium), severe dysplasia (marked architectural changes involving more than two-thirds of epithelium) and carcinoma in situ (severe form of epithelial dysplasia characterized by full thickness or almost full thickness cytological and architectural changes). [ 28 29 ]…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma

Shyam

Rao

Narang

et al. 2014

J Oral Maxillofac Pathol

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Background:Cyclin dependent kinase-4 (CDK4) encoded by CDK gene, is a heterodimer protein of cell cycle in G1-S transition. This study aimed to characterize the CDK4 immunoreactivity in different histological grades of oral leukoplakias (OLs) and oral squamous cell carcinomas (OSCCs) and also aims to discuss its probable role in the tumor biogenesis.Materials and Methods:Expression of CDK4 was investigated in total of 52 samples including OL (15), OSCCs (30) and normal oral tissues (07). A labeled Streptavidin-Biotin immunohistochemistry assay was performed and staining intensity was evaluated.Results:The staining pattern was similar in all tissues and was located in both nuclei and cytoplasm. Dysplastic epithelium displayed a progressive increase in nuclear expression of CDK4 when compared to normal tissues. Also, positive staining cytoplasm was highly evident in OSCC with loss of differentiation.Conclusion:Our study indicated a progressive over expression of CDK4 from normal to leukoplakias (various histological grades of dysplasias) and OSCCs.

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“…The word dysplasia denotes abnormal growth. [ 25 ] The dysplastic alterations may revert to normal when the underlying inciting stimulus is removed. Dysplastic features in stratified squamous epithelium are characterized by cellular atypia and loss of normal maturation and stratification.…”

Section: Malignant Transformation Of Oral Potentially Malignant Disormentioning

confidence: 99%

Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders

Ranganathan

Kavitha

2019

J Oral Maxillofac Pathol

136

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An Insight to Oral Epithelial Dysplasia

Cited by 21 publications

References 17 publications

A Clinicopathologic and Epidemiologic Study of Chronic White Lesions in the Oral Mucosa

A Clinicopathologic and Epidemiologic Study of Chronic White Lesions in the Oral Mucosa

Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma

Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders

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