An insight of non-steroidal anti-inflammatory drug mefenamic acid: A review

Rajat, Srivastava; Mishra, Manoj Kumar; Patel, Amit; Singh, Abhishek; Kushwaha, Krishna

doi:10.30574/gscbps.2019.7.2.0066

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…Hasil penelitian dari (Srivastava et al, 2019) juga mendukung hasil yang diperoleh yang mejelaskan bahwa waktu paruh biologis asam mefenamat yang pendek adalah 2 jam. Karena waktu paruh yang singkat, dosis oral diperlukan untuk pemberian obat yang sering untuk mempertahankan tingkat keadaan yang diinginkan.…”

Section: Pembahasanunclassified

Efektivitas Asam Mefenamat Dibandingkan Dengan Ibuprofen L-Arginine Sebagai Terapi Analgesik

Sari,

Nayoan

2023

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Latar belakang:Analgesik merupakan obat yang digunakan untuk mengurangi atau menghilangkan rasa sakit atau obat penghilang rasa sakit tanpa kehilangan kesadaran. Obat ini digunakan untuk membantu meredakan nyeri, secara sadar atau tidak sadar. Ibuprofen dan Asam Mefenamat merupakan golongan NSAID yang paling umum digunakan dan terbukti berkhasiat sebagai obat inflamasi dan analgesik. Dari beberapa penelitian, NSAID lebih baik dalam menghilangkan nyeri dibandingkan dengan Parasetamol. NSAID yang paling popular iyalah diklofenak, diikuti Ibuprofen, Asam mefenamat dan neproksen berdasarkan data penjualan dan daftar obat essensial di beberapa negara. Tujuan :Mengetahui efektivitas Asam mefenamat dibandingkan dengan Ibuprofen L-arginine sebagai analgesik. Metode : Penelitian ini merupakan penelitian Quasi Experimental dengan rancangan design double blind controlled trial. Dengan stimulus nyeri menggunakan pain latency dengan penilaian berdasarkan VAS selama 3 jam observasi. Hasil :Penelitian setiap kelompok obat, terlihat perbedaan waktu yang signifikan. Pada kelompok Ibuprofen L-Arginine memiliki nilai rata-rata 84,21 detik sedangkan pada kelompok Asam Mefenamat hanya memiliki rata-rata 63.04. dari data menunjukkan bahwa pada kelompok Ibuprofen L-arginine 600 mg dibandingkan dengan Asam Mefenamat memiliki perbedaan rata-rata 21,17 detik (p 0,0036). Kesimpulan :Terdapat perbedaan signifikan terhadap efektivitas analgesia antar kelompok Asam mefenamat dengan Ibuprofen L-arginin dimana Asam mefenamat memiliki efektifitas analgesia yang lebih lambat dibandingkan dengan Ibuprofen L-arginine.

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Section: Pembahasanunclassified

Efektivitas Asam Mefenamat Dibandingkan Dengan Ibuprofen L-Arginine Sebagai Terapi Analgesik

Sari,

Nayoan

2023

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“…Mefenamic acid is a commercial non‐steroidal anti‐inflammatory drug (NSAID) and its COX‐2 inhibition activities have already been established . The NSAID binding site of COX‐2 is a long hydrophobic channel, which prompted us to synthesize the G ‐ A ‐ M molecules using amino acids having hydrophobic side chains and protected glucopyranose residue for better recognition.…”

Section: Figurementioning

confidence: 99%

Synthesis of Mefenamic Acid Containing N ‐Glycoconjugates and Their Evaluation as Human COX‐2 Enzyme Inhibitor

Madduluri

Sah

2020

ChemistrySelect

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A series of d‐glucose derived N‐glycopeptides containing mefenamic acid have been synthesised and in vitro evaluation of all these molecules have been performed as COX‐2 (human) enzyme inhibitor using Enzymes Immuno Assay kit. These studies were further supported by docking experiments on human COX‐2 enzyme (PDB ID: 5IKR). All the compounds exhibited a fair amount of COX‐2 enzyme inhibition during both the modes of study and tryptophan derivative showed the best activity. Acute toxicity (LD50) in rat has also been evaluated using General Unrestricted Structure‐Activity Relationships (GUSAR) software, where acute oral toxicity for most of the molecules was found to be less than the pure mefenamic acid.

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“…The pathophysiological functions of MA are implemented by its ability to inhibit the biosynthesis of prostaglandin involved in pathogen diseases. MA is used to treat rheumatoid arthritis, osteoarthritis, autoimmune hemolytic anemia, sports injuries, gastrointestinal disorders, primary dysmenorrhea muscle pain, back pain, and dental pain [2][3][4][5]. As MA works on cyclooxygenase (COX) pathways and suppresses prostaglandin, the sensations of pain are momentarily lessened.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an Electrocatalyst Based on Rare Earth Manganites Incorporated with Carbon Nanofiber Hybrids: An Efficient Electrochemical Biosensor for the Detection of Anti-Inflammatory Drug Mefenamic Acid

Alagarsamy

Sundaresan

Chen

et al. 2023

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Pharmaceutical and personal care products are emerging as a new category of environmental pollution. Analytical drug detection from a biological sample for detection is still crucial today. Mefenamic acid (MA) is an anti-inflammatory drug utilized for its antipyretic and analgesic properties, which is harmful to patients at higher dosages and is also recognized as a chemical pollutant that harms the environment. In this view, Dysprosium manganite/carbon nanofiber (DMO/CNF) was prepared by hydrothermal method for the electrochemical detection of MA. DMO/CNF/GCE exhibits high selectivity, excellent anti-interference, good stability, and reproducibility toward the detection of MA. The enhanced electrochemical performance of DMO/CNF/GCE was attributed to their synergetic interaction. Under optimized conditions, DMO/CNF/GCE shows a wide linear range of 0.01–741 μM and a low LOD of 0.009 μM. Satisfactory recoveries were obtained for human blood and tablet samples. Thus, the proposed DMO/CNF nanocomposite emerges as a promising material for the detection of MA.

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An insight of non-steroidal anti-inflammatory drug mefenamic acid: A review

Cited by 11 publications

References 11 publications

Efektivitas Asam Mefenamat Dibandingkan Dengan Ibuprofen L-Arginine Sebagai Terapi Analgesik

Efektivitas Asam Mefenamat Dibandingkan Dengan Ibuprofen L-Arginine Sebagai Terapi Analgesik

Synthesis of Mefenamic Acid Containing N ‐Glycoconjugates and Their Evaluation as Human COX‐2 Enzyme Inhibitor

Fabrication of an Electrocatalyst Based on Rare Earth Manganites Incorporated with Carbon Nanofiber Hybrids: An Efficient Electrochemical Biosensor for the Detection of Anti-Inflammatory Drug Mefenamic Acid

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