An insight into the anticancer mechanism of Tribulus terrestris extracts on human breast cancer cells

Patel, Apurva; Soni, Anjali; Siddiqi, Nikhat J.; Sharma, Preeti

doi:10.1007/s13205-019-1585-z

Cited by 22 publications

(15 citation statements)

References 26 publications

(25 reference statements)

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“…Our results support the previous studies that claimed antitumor activity of T. terrestris [ 2 , 3 ]. In this study, the extract of the whole plant was investigated, while Patel et al, Goranova et al, and Angelova et al proved both cytotoxic and antiapoptotic effect of its seed and leaf against MCF7 and MCF-10A cells [ 4 , 5 , 45 ]. Previously, Majed and Ali demonstrated cytotoxic activity of the pollen extract of T. domingensis against MCF7 cells [ 11 ], while the vegetative part of the same plant was tested in this study against the same cell line and showed twelve folds more activity compared to the pollen part.…”

Section: Resultsmentioning

confidence: 99%

“…Although T. terrestris has not been extensively studied for detailed anticancer activities, several investigations indicated its potential cytotoxic activity. In a recent study, Patel et al (2019) reported that methanolic and saponin extracts of T. terrestris exhibited cytotoxic activity probably through extrinsic and intrinsic apoptotic pathways [ 4 ]. Namely, the seed and leaf extracts induced apoptosis and DNA fragmentation in human breast cancer MCF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical, Cytotoxic, and Antimicrobial Evaluation of Tribulus terrestris L., Typha domingensis Pers., and Ricinus communis L.: Scientific Evidences for Folkloric Uses

Khalid

Algarni

Homeida

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Many medicinal plants have been utilized for centuries despite the lack of scientific evidence of their therapeutic effects. This study evaluated the phytochemical and dual biological profiling, namely, antibacterial and cytotoxic properties, of three plant species, namely, Tribulus terrestris L., Typha domingensis Pers., and Ricinus communis L., in order to explore potential relationships (if any) with their ethnopharmacological uses. GC-MS was used to achieve phytochemical screening of two plant extracts (T. terrestris and T. domingensis). The primary chemicals detected in varying amounts in both extracts were siloxane derivatives, fatty acid esters, diisooctyl phthalate, phytosterol, and aromatic acid esters. According to the findings, the major component detected in both extracts was 1,2-benzenedicarboxylic acid and diisooctyl ester (antibacterial and antifungal). T. domingensis contained a low level of benzoic acid, methyl ester (antibacterial). Both extracts included stigmasterol and sitosterol, as well as six different forms of fatty acid esters. Antimicrobial, antioxidant, anticancer, thyroid inhibitor, and anti-inflammatory properties have all been described. Human breast adenocarcinoma (MCF7), human ovary adenocarcinoma (A2780), and human colon adenocarcinoma (HT29), as well as normal human fetal lung fibroblasts (MRC5), all showed cytotoxic activity. The most potent activity against A2780 cells was seen in T. terrestris and T. domingensis extracts (IC50: 3.69 and 5.87 g/mL, respectively). R. communis was more active against MCF7 cells (1.52 μg/mL) followed by A2780 and HT29 cells, respectively. R. communis showed a dose-dependent clonogenic effect against MCF7 cells. The antibacterial activity of all three plant extracts was tested against three standard Gram-positive, four standard Gram-negative, and two clinical bacterial strains. Among the three extracts examined, T. terrestris was the most effective, followed by R. communis, and finally, T. domingensis plant extract was effective against various isolated bacteria. This study, interestingly, sheds light on the bioactive components found in plant extracts that can be utilized for cytotoxic and antibacterial purposes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical, Cytotoxic, and Antimicrobial Evaluation of Tribulus terrestris L., Typha domingensis Pers., and Ricinus communis L.: Scientific Evidences for Folkloric Uses

Khalid

Algarni

Homeida

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In the study by Apurva et al, the extract of the Tribulus terrestris plant seems to increase the caspase 3 activity of the human breast cancer cell line [51]. In the study by Masoud et al, the herb is also found to have anticancer activity against prostate and colon cancer cell lines [52].…”

Section: Resultsmentioning

confidence: 97%

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

Kamalli

Subramanian

Ezhilarasan

et al. 2021

JPRI

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Introduction: Breast cancer is the form of cancer that occurs in the breast cells. After skin cancer, breast cancer is considered to be the most common cancer diagnosed in women. The number of deaths associated with this disease was increased in case of lack of early detection. Tribulus terrestris is an annual herb belonging to the Zygophyllaceae family. Flavonoids, alkaloids, and saponins are some of the main phytoconstituents of the herb. They are known for their pharmacological actions such as anti carcinogenic, anti inflammatory, antimicrobial, antioxidant properties. Aim: The aim of the present study is to evaluate the antitumor activity of ethanolic extract from Tribulus terrestris in MCF-7 human breast cancer cells. Materials and Methods: The effect of Tribulus terrestris on cell viability was measured by MTT assay carried against breast cancer cells and morphological changes were investigated with phase contrast microscopy to confirm its antitumor activity. Results: the cell viability assay results indicate that 24hrs treatment with ethanolic extract of significantly reduces the cell viability in dose dependent manner. At 40 μg/ml of the Tribulus terrestris extract inhibits 50% cell viability and it has been fixed as IC50 value for further Tribulus terrestris experiments. Conclusion: From the results, the extracts were cytotoxic to the human breast cancer cell and it might be a good therapeutic value for further investigations needed to understand the mechanisms to develop antitumor agents.

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“…Naz ability at 100 ppm concentration and 80.54% cell viability at 12.50 ppm on MCF-7 cell line. It had been reported that the leaves of the plant cause 98.46 % and 69.51 % cell viability on MCF-7 cells at 100 ppm and 12.50 ppm concentrations, respectively [30]. The biological activity of a plant sample varies according to many conditions such as the solvent used in the isolation of its phenolic compounds, extraction technique, climate, coordinates, altitude, soil quality and fertilizer used [31,32].…”

Section: Mtt Assaymentioning

confidence: 99%

Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay

Akbaba

Öztürkkan

Sertçelik

2021

Hittite Journal of Science and Engineering

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I t is known that human beings used only natural medicines until 1800 in the treatment of diseases. Compounds obtained through isolation from natural sources since the beginning of 1800 have been synthesized in the laboratory environment since 1830 [1]. In recent years, the belief that natural remedies are safer than synthetic drugs have led to an increase in people's use of natural products such as herbs, phytotherapeutics and phytopharmaceuticals. Therefore, researchers conduct various studies on the biological significance of plant extracts [2, 3]. However, there is no regulatory system that determines the safety and required dose of natural products, or even commercially sells them. The most widely used of these natural products are herbs. Unfortunately, most of those who use these herbs therapeutically do not have adequate knowledge or training in the safe use of the products. For these reasons, many studies are required to standardize natural plant products and evaluate possible risks such as undesirable side effects, overdose and toxicity [4].Tribulus terrestris L. is known in Turkey as "deve çökerten", "çoban çökerten" and "çarık dikeni". These names were given to the plant because its fruit has horn-shaped spikes (Figure 1

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An insight into the anticancer mechanism of Tribulus terrestris extracts on human breast cancer cells

Cited by 22 publications

References 26 publications

Phytochemical, Cytotoxic, and Antimicrobial Evaluation of Tribulus terrestris L., Typha domingensis Pers., and Ricinus communis L.: Scientific Evidences for Folkloric Uses

Phytochemical, Cytotoxic, and Antimicrobial Evaluation of Tribulus terrestris L., Typha domingensis Pers., and Ricinus communis L.: Scientific Evidences for Folkloric Uses

Evaluation of Antitumour Activity of Ethanolic Extract from Tribulus terrestris in Human Breast Cancer Cells

Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay

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