An injectable hydrogel derived from small intestine submucosa as a stem cell carrier

Kim, Kyung-Sook; Kim, Moon Suk

doi:10.1002/jbm.b.33504

Cited by 19 publications

(12 citation statements)

References 33 publications

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“…The SIS powder was dissolved in PBS at 20% w/v and shaped into a gel of any shape overnight at 37 °C [ 41 , 47 , 50 ]. For example, SIS hydrogel placed on the bottom of the culture dish forms a flat shape [ 41 , 51 ], or put in a small bottle forms a thicker cylindrical shape. The hydrogel can also be injected into a specific area with a syringe based on the good fluidity of hydrogel.…”

Section: Overview Of Sismentioning

confidence: 99%

Surface modification of small intestine submucosa in tissue engineering

Pan

Qin

et al. 2020

Regenerative Biomaterials

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With the development of tissue engineering, the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in vivo. Especially, surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials. The small intestine submucosa (SIS) is an extracellular matrix isolated from the submucosal layer of porcine jejunum, which has good tissue mechanical properties and regenerative activity, and is suitable for cell adhesion, proliferation and differentiation. In recent years, SIS is widely used in different areas of tissue reconstruction, such as blood vessels, bone, cartilage, bladder and ureter, etc. This paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds, including functional group bonding, protein adsorption, mineral coating, topography and formatting modification and drug combination. In addition, the reasonable combination of these methods also offers great improvement on SIS surface modification. This article makes a shallow review of the surface modification of SIS and its application in tissue engineering.

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Section: Overview Of Sismentioning

confidence: 99%

Surface modification of small intestine submucosa in tissue engineering

Pan

Qin

et al. 2020

Regenerative Biomaterials

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“…Most importantly, when transplanting cells in vivo , the use of the HAMC hydrogel improved RPC distribution through the impacted area compared to saline, as well as improved grafted retinal rod survival and functional visual integration [142, 166]. Engineering new muscle through regenerative medicine strategies has also shown promise through enhanced delivery and survival of MSCs, muscle stem cells, and skeletal muscle satellite cells using thermosensitive, injectable hydrogels such as collagen/chitosan/βGP [167], composite synthetic polymers PNIAPPAM/acrylic acid/2-hydroxyethyl methacrylate-oligomers [168], small intestinal submucosa [169], and fibrin [33]. Wound healing has also been a targeted research area for potential stem cell-derived therapies.…”

Section: Specific Hydrogel Design Choices For Specific Tissue Applmentioning

confidence: 99%

Design of Injectable Materials to Improve Stem Cell Transplantation

2016

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Stem cell-based therapies are steadily gaining traction for regenerative medicine approaches to treating disease and injury throughout the body. While a significant body of work has shown success in preclinical studies, results often fail to translate in clinical settings. One potential cause is the massive transplanted cell death that occurs post injection, preventing functional integration with host tissue. Therefore, current research is focusing on developing injectable hydrogel materials to protect cells during delivery and to stimulate endogenous regeneration through interactions of transplanted cells and host tissue. This review explores the design of targeted injectable hydrogel systems for improving the therapeutic potential of stem cells across a variety of tissue engineering applications with a focus on hydrogel materials that have progressed to the stage of preclinical testing.

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“…Many studies have shown that the reaction formed orthogonally cross-linked hydrogels at a very fast rate, and it was air insensitive and proceeded in aqueous media as well as under physiological conditions [13][14][15][16]. Over the past decade, injectable hydrogels have attracted much attention owing to simple production processes, excellent properties, and without surgical procedures, which could reduce the patient's discomfort [17,18]. Biocompatibility of polymeric hydrogels is an important property, which is used inside the microenvironment of the human body.…”

mentioning

confidence: 99%

Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride)

Anugrah¹,

Patil²,

Li³

et al. 2020

Express Polym. Lett.

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A hydrogel is a cross-linked three-dimensional product of macromolecular hydrophilic networks. Due to their unique properties, hydrogels have been extensively studied for tissue engineering, especially, they have excellent biocompatibility and the capability to be the type of drug delivery system [1, 2]. The high water content provides them with properties similar to natural extracellular matrixes. The risk of the drug denaturation and aggregation due to exposure to an organic solvent can be minimized by hydrogels. The internal network makes hydrogels have solid-like properties. Hydrogel networks may be physical gels or chemical gels. Physical gels form through physical interactions, while chemical gels are held together by covalent bonds. Chemical gel methods for making the internal network have made significant progress so far. Click chemistry, one of the methods, provided hydrogels with moderately high mechanical properties [3-6] and was also useful in biomedical engineering [7-12]. The emerging studies in click chemistry have generated 'metal-free' reactions. One example of interesting metal-free click chemistry is the inverse 248

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An injectable hydrogel derived from small intestine submucosa as a stem cell carrier

Cited by 19 publications

References 33 publications

Surface modification of small intestine submucosa in tissue engineering

Surface modification of small intestine submucosa in tissue engineering

Design of Injectable Materials to Improve Stem Cell Transplantation

Click-cross-linked, doxorubicin-loaded hydrogels based on poly(styrene-alt-maleic anhydride)

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