Surface modification of small intestine submucosa in tissue engineering

Pan, Zhao; Li, Xiang; Qin, Fang; Wang, Fanglin; Ao, Qiang; Wang, Xiaohong; Tian, Xiaohong; Hao, Tong; Bai, Shuling; Fan, Jun

doi:10.1093/rb/rbaa014

Cited by 45 publications

(39 citation statements)

References 110 publications

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“…With preserved bioactive factors and growth factors, SIS has gained much attention in tissue engineering and subsequent clinical applications as a highly supportive scaffold ( Fig. 7 ) [ 62 ]. More recently, in vivo research on the application of porcine SIS in the treatment of IUAs demonstrated that SIS can change the receptive factors (higher expressions of uteroglobin and HOXA10) and significantly increase endometrial thickness and reduce the percentage of fibrotic areas in IUA rat modes [ 63 ].…”

Section: Postoperative Adjuvant Therapy Methodsmentioning

confidence: 99%

Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Ma¹,

Zhan

et al. 2021

Biomater Res

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Intrauterine adhesion (IUA) is a common gynaecological disease that develops from infection or trauma. IUA disease may seriously affect the physical and mental health of women of childbearing age, which may lead to symptoms such as hypomenorrhea or infertility. Presently, hysteroscopic transcervical resection of adhesion (TCRA) is the principal therapy for IUAs, although its function in preventing the recurrence of adhesion and preserving fertility is limited. Pharmaceuticals such as hormones and vasoactive agents and the placement of nondegradable stents are the most common postoperative adjuvant therapy methods. However, the repair of injured endometrium is relatively restricted due to the different anatomical structures of the endometrium. Recently, the treatment outcome of IUAs has improved with the advancement of hysteroscopic techniques. In particular, the application of bioactive scaffolds combined with tissue engineering technology has proven to have high therapeutic potential or endometrial repair in IUA treatment. Herein, this review has summarized past therapeutic strategies, including postoperative adjuvant therapy, cell or therapeutic molecular delivery therapy methods and bioactive scaffold-based tissue engineering methods. Therefore, this review presented the recent therapeutic strategies for repairing endometrium treatment and pointed out the issues of clinical concern to provide alternative methods for the management of IUAs.

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Section: Postoperative Adjuvant Therapy Methodsmentioning

confidence: 99%

Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Ma¹,

Zhan

et al. 2021

Biomater Res

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“…Recently, the use of small intestine submucosa (SIS) has been also proposed for the production of large and small TEVGs [ 183 ]. Typically, SIS can be derived either from the porcine or ovine origin [ 184 ].…”

Section: Decellularized Vascular Graftsmentioning

confidence: 99%

Future Perspectives in Small-Diameter Vascular Graft Engineering

et al. 2020

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The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal groups of non-communicable disorders worldwide. It has been estimated that in Europe, the healthcare cost for the administration of CVD is more than 169 billion €. Common manifestations involve the narrowing or occlusion of blood vessels. The replacement of damaged vessels with autologous grafts represents one of the applied therapeutic approaches in CVD. However, significant drawbacks are accompanying the above procedure; therefore, the exploration of alternative vessel sources must be performed. Engineered SDVGs can be produced through the utilization of non-degradable/degradable and naturally derived materials. Decellularized vessels represent also an alternative valuable source for the development of SDVGs. In this review, a great number of SDVG engineering approaches will be highlighted. Importantly, the state-of-the-art methodologies, which are currently employed, will be comprehensively presented. A discussion summarizing the key marks and the future perspectives of SDVG engineering will be included in this review. Taking into consideration the increased number of patients with CVD, SDVG engineering may assist significantly in cardiovascular reconstructive surgery and, therefore, the overall improvement of patients’ life.

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“…Besides nanopatterning, micropatterning is also a unique tool for fundamental studies of interactions between cells and materials [45][46][47][48][49][50][51][52][53][54]. In particular, cells were found to adhere on adhesive microislands only over a critical size [55,56].…”

Section: Introductionmentioning

confidence: 99%

Critical adhesion areas of cells on micro-nanopatterns

Zheng

Liu

et al. 2021

Nano Res.

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Cell adhesion to extracellular matrices (ECM) is critical to physiological and pathological processes as well as biomedical and biotechnological applications. It has been known that a cell can adhere on an adhesive microisland only over a critical size. But no publication has concerned critical adhesion areas of cells on microislands with nanoarray decoration. Herein, we fabricated a series of micro-nanopatterns with different microisland sizes and arginine-glycine-aspartate (RGD) nanospacings on a nonfouling poly(ethylene glycol) background. Besides reproducing that nanospacing of RGD, a ligand of its receptor integrin (a membrane protein), significantly influences specific cell adhesion on bioactive nanoarrays, we confirmed that the concept of critical adhesion area originally suggested in studies of cells on micropatterns was justified also on the micro-nanopatterns, yet the latter exhibited more characteristic behaviors of cell adhesion. We found increased critical adhesion areas of human mesenchymal stem cells (hMSCs) on nanoarrayed microislands with increased RGD nanospacings. However, the numbers of nanodots with respect to the critical adhesion areas were not a constant. A unified interpretation was then put forward after combining nonspecific background adhesion and specific cell adhesion. We further carried out the asymptotic analysis of a series of micro-nanopatterned surfaces to obtain the effective RGD nanospacing on unpatterned free surfaces with densely grafted RGD, which could be estimated nonzero but has never been revealed previously without the assistance of the micro-nanopatterning techniques and the corresponding analysis.

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Surface modification of small intestine submucosa in tissue engineering

Cited by 45 publications

References 110 publications

Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion

Future Perspectives in Small-Diameter Vascular Graft Engineering

Critical adhesion areas of cells on micro-nanopatterns

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