An Implantable 455-Active-Electrode 52-Channel CMOS Neural Probe

López, Carolina Mora; Alexandru, Andrei; Mitra, Srinjoy; Welkenhuysen, Marleen; Eberle, Wolfgang; Bartic, Carmen; Puers, Robert; Yazıcıoğlu, Refet Fırat; Gielen, Georges

doi:10.1109/jssc.2013.2284347

Cited by 217 publications

(85 citation statements)

References 34 publications

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“…This technique spread throughout the MEMS community and formed the basis for many other novel electromechanical structures. The planar lithography approach has evolved over the years to include integrated interconnects 38 , active electronics 35,39,40 , cochlear implants 41,42 , polytrodes 31 , and three-dimensional arrays 29,[43][44][45] . An important simplification for defining and releasing fine neural probe structures has been the use of silicon-on-insulator (SOI) wafers and deep reactive ion etching (DRIE) 46,47 that many groups have adopted.…”

Section: Recording Brain Activity Brief Historymentioning

confidence: 99%

“…Some of most advanced silicon designs include double-sided, high-density arrays 29,102 , three-dimensional arrangements 43 , and integrated electronics 39,40,132 . Although the inherent brittleness of silicon is a concern for some clinical applications, its electrical, mechanical, and thermal properties offer the greatest design options and are supported by a wide range of commercial microfabrication tools.…”

Section: Substrate Materials and Microfabricationmentioning

confidence: 99%

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State-of-the-art MEMS and microsystem tools for brain research

et al. 2017

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Mapping brain activity has received growing worldwide interest because it is expected to improve disease treatment and allow for the development of important neuromorphic computational methods. MEMS and microsystems are expected to continue to offer new and exciting solutions to meet the need for high-density, high-fidelity neural interfaces. Herein, the state-of-the-art in recording and stimulation tools for brain research is reviewed, and some of the most significant technology trends shaping the field of neurotechnology are discussed.

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Section: Recording Brain Activity Brief Historymentioning

confidence: 99%

Section: Substrate Materials and Microfabricationmentioning

confidence: 99%

State-of-the-art MEMS and microsystem tools for brain research

et al. 2017

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“…However, AC-coupled inverting amplifiers with capacitive feedback [27] address both issues, thus being widely used in wearable and implantable medical instruments [28] [29]. An AE built with a capacitively coupled inverting amplifier [30] is shown in Fig.…”

Section: B Inverting Amplifiersmentioning

confidence: 99%

Active Electrodes for Wearable EEG Acquisition: Review and Electronics Design Methodology

Mitra

Hoof

et al. 2017

IEEE Rev. Biomed. Eng.

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130

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Abstract-Active Electrodes (AE), i.e. electrodes with built-in readout circuitry, are increasingly being implemented in wearable healthcare and lifestyle applications due to AE's robustness to environmental interference. An AE locally amplifies and buffers µV-level EEG signals before driving any cabling. The low output impedance of an AE mitigates cable motion artifacts thus enabling the use of high-impedance dry electrodes for greater user comfort. However, developing a wearable EEG system, with medical grade signal quality on noise, electrode offset tolerance, common-mode rejection ratio (CMRR), input impedance and power dissipation, remains a challenging task. This paper reviews state-of-the-art bio-amplifier architectures and low-power analog circuits design techniques intended for wearable EEG acquisition, with a special focus on AE system interfaced with dry electrodes. Index Terms-Active electrode, instrumentation amplifier (IA), electroencephalography (EEG), dry electrodes, common-mode rejection ratio (CMRR), brain-computer interface (BCI)I. INTRODUCTION ecent advances in biomedical technologies, integrated circuits (ICs), sensors and data analysis techniques have accelerated the development of wearable technology for Telehealth applications. Today, miniature and low-power medical sensors can be easily integrated into various accessories that continuously sense, process and transfer people's physiological information during their daily life activities. By reducing the need for manual intervention and by lowering the cost, these medical devices are being widely used in personal healthcare and home diagnostics, such as wellness and health monitoring, home rehabilitation, and the early detection of brain disordersElectroencephalography (EEG)

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“…A sensor site and the surrounding stimulation site can be seen in Fig. 1b Besides the comparably large, planar in-vitro systems, which are in the focus of this contribution, there are also CMOS-based needle-type probes for recording and stimulation in vivo that have been pioneered at the University of Michigan [3,[29][30][31][32][33] and adopted by other groups ( Figure 2) [34][35][36][37]. Such electrode arrays are inserted into the living brain and facilitate advances in the understanding of the nervous system.…”

Section: Cmos High-density Systemsmentioning

confidence: 99%

Direct interfacing of neurons to highly integrated microsystems

Hierlemann

2017

2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)

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The use of large high-density transducer arrays enables fundamentally new neuroscientific insights through enabling high-throughput monitoring of action potentials of larger neuronal networks (> 1000 neurons) over extended time to see effects of disturbances or developmental effects, and through facilitating detailed investigations of neuronal signaling characteristics at subcellular level, for example, the study of axonal signal propagation that has been largely inaccessible to established methods. Applications include research in neural diseases and pharmacology.

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An Implantable 455-Active-Electrode 52-Channel CMOS Neural Probe

Cited by 217 publications

References 34 publications

State-of-the-art MEMS and microsystem tools for brain research

State-of-the-art MEMS and microsystem tools for brain research

Active Electrodes for Wearable EEG Acquisition: Review and Electronics Design Methodology

Direct interfacing of neurons to highly integrated microsystems

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