An extramedullary plasmacytoma in the kidney of a 14-year-old girl

Abstract

Rationale:Extramedullary plasmacytoma (EMP) a rare plasma cell disorder and is frequently associated with plasma cell bone marrow infiltration. Most EMPs involve mucosal lymphoid tissue, especially in the nasopharyngeal area, respiratory tract, and head and neck region. Primary involvement of the kidney is exceedingly rare.Patient Concerns:A 14-year-old girl was admitted in our hospital with intermittent right upper quadrant pain for 1 month and recent (1 day) progressive deterioration. There was a mass found by ultrasonography in the right kidney and subsequent abdominal computed tomography scan revealed a 3 cm mass within the right kidney.Diagnoses:Pathology revealed typical histology of plasmacytoma and immunohistochemistry revealed the expression of CD138, CD45, vimentin, and Kappa light chain.Interventions:The patient successfully underwent radical nephrectomy with an uneventful recovery. She received no chemotherapy or radiotherapy after surgery.Outcomes:There was no recurrence or metastasis during a 22-month follow-up.Lessons:Our case study demonstrated that renal EMP with a relatively indolent clinical course, if detected at an early stage, can be treated by radical nephrectomy without adjuvant therapy. Generally, the clinical outcome and prognosis of EMP are favorable

Refractory primary extramedullary plasmacytoma in kidney: a case report

“…2 A comprehensive literature search of the PubMed, Medline and Embase databases, for English language articles on renal plasmacytoma (excluding articles involving secondary EMPs and cases with bone marrow involvement) revealed 16 published cases (11 male and 5 female; median age, 56.8 years [range, 14-76 years]) arising in the kidney (Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Among these cases, 10 (62.5%) showed primary EMP lesions in the left kidney, five (31.25%) were in the right kidney, and one (6.25%) was in both kidneys, resulting in renal insufficiency without obvious obstruction or hydronephrosis. Five cases (31.25%) presented with abdominal or back pain, and four (25%) showed haematuria.…”