Refractory primary extramedullary plasmacytoma in kidney: a case report

Abstract

Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm, with the majority (80–90% of cases) occurring in the upper aerodigestive tract. To our best knowledge, primary EMP from renal tissues is extremely rare. Herein, the diagnosis and treatment of a refractory primary EMP with renal involvement in a 53-year-old male patient is reported. The patient received radical nephrectomy followed by radiotherapy, and showed relapse 3 months after treatment. The cancer cells were sensitive to subsequent chemotherapy, however, the patient died of infection associated with the disease after almost 3.5 years following first presentation.

Direct infiltration of clonal plasma cells causes renal insufficiency in patients with monoclonal gammopathy of undetermined significance

“…Our case and the five cases mentioned above had no histopathological evidence suggestive of any of the renal lesions listed above. Our case was also distinctive from renal plasmacytoma, as the clonal cells did not form a mass nor proliferate to destroy surrounding structures [8, 9]. Renal damage by direct invasion of malignant plasma cells was previously reported in patients with MM.…”