An experimental study of the mitochondria in the hepatic cells of the white rat

The correlation between changes in the cell organelles and the processes of storage and secretion is one of the fundamental problems of cytology. I n the liver many of the activities of the cell are known through biochemical studies, and in certain instances the products of these activities-e.g. bile acids, glycogen, and fat-can be demonstrated histologically. Several suggestions have appeared in the literature of interrelationships between the organelles and the processes associated with alimentation, but no comprehensive study has been undertaken. The present investigation is such a study of the relationship between changes in the mitochondria and the Golgi substance on the one hand and the secretion of bile acids and the storage of glycogen and fat on the other.Recently Forsgren ( '35) and his associates have described reciprocal diurnal cycles in the deposition of glycogen and in the secretion of the bile components (actually the bile acids, because of the method of demonstration). According to their observations the greatest amount of glycogen is present in the liver during the night, whereas the largest amount of bile acid material is secreted during the afternoon. Except ' A portion of a thesis submitted in partial fulfillment of the requirements for a Horton-Hallowell Fellow of Wellesley College, 1942-43. the degree of Doctor

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An experimental study of the mitochondria in the hepatic cells of the white rat

Cited by 11 publications

References 20 publications

A morphological and histochemical study of the rat's adrenal cortex after hypophysectomy, with comments on the liver

A morphological and histochemical study of the rat's adrenal cortex after hypophysectomy, with comments on the liver

A study of the hepatic‐cell mitochondria in the fatty liver produced by a high‐sugar diet

A cytological study of the diurnal cycle of the liver of the mouse in relation to storage and secretion

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