An Experimental Study of Prolonged Left Heart Bypass Without Thoracotomy

Hall, David P.; Moreno, Juan R.; Dennis, Clarence; Senning, Å

doi:10.1097/00000658-196208000-00004

Cited by 29 publications

(1 citation statement)

References 6 publications

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“…Although the use of mechanical circulatory support was postulated as early as 1812 by LeGallois (LeGallois et al 1813), it was not until 1961 that the first clinical left heart bypass was performed by Hall et al (1962). It was almost eight years later that Cooley (1969) implanted the first artificial heart into the chest of a patient for over 60 hours before replacing the device with a human donor heart.…”

Section: Introductionmentioning

confidence: 99%

Experimental Fluid Mechanics of Pulsatile Artificial Blood Pumps

Deutsch

Tarbell

Manning³

et al. 2006

Annu. Rev. Fluid Mech.

101

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The fluid mechanics of artificial blood pumps has been studied since the early 1970s in an attempt to understand and mitigate hemolysis and thrombus formation by the device. Pulsatile pumps are characterized by inlet jets that set up a rotational "washing" pattern during filling. Strong regurgitant jets through the closed artificial heart valves have Reynolds stresses on the order of 10,000 dynes/cm 2 and are the most likely cause of red blood cell damage and platelet activation. Although the flow in the pump chamber appears benign, low wall shear stresses throughout the pump cycle can lead to thrombus formation at the wall of the smaller pumps (10-50 cc). The local fluid mechanics is critical. There is a need to rapidly measure or calculate the wall shear stress throughout the device so that the results may be easily incorporated into the design process. 65 Annu. Rev. Fluid Mech. 2006.38:65-86. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/04/15. For personal use only.

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Section: Introductionmentioning

confidence: 99%