An Experience of Administration of Inhaled Tobramycin in Severe Nosocomial Pneumonia

Inhaled Tobramycin in the Treatment of Nosocomial Pneumonia in Severe Sepsis

“…Hearing loss and tinnitus was detected only in 2 patients in our study. There were no cases of bronchospasm or kidney dysfunction in our study, which is in accordance with the other trials [17,18].…”

“…But we have a clinical experience of an effective monotherapy with IT in a patient with severe allergic reaction to systemic antibiotics. Currently it is not recommended to use IA for the NP prophylaxis [15][16][17][18][19].…”

“…Only special preparations for inhalation must be used to prevent these complications. Inhaled antibiotics and nebulizers are expensive, their use is associated with the environment pollution and resistance formation [17][18][19].…”

Perspectives of the Inhaled Antibiotics Usage in Pediatrics

“…The inhaled antibiotics have a long history of usage in the treatment of infections of the lower respiratory tract 1 . They have been used for over 50 years in different age groups of pulmonary patients 8 . The usage of these drugs in patients with cystic fibrosis, chronic carriers of Pseudomonas aeruginosa, has been widespread.…”

“…It is important to note that the inhaled antibiotics are not used as a monotherapy without systemic drugs, because their degree of absorption into the blood is low (2-4%) and not sufficient for systemic effect and treatment of concomitant infections and secondary lesions 8 .…”