Perspectives of the Inhaled Antibiotics Usage in Pediatrics

Boyarchuk, Oksana; KRYTSKA, Halyna; CHORNOMYDZ, Andrii; PELYKH, Volodymyr; Chornomydz, I. B.; Kosovska, T.M.; HORISHNYI, Ihor

doi:10.31688/abmu.2018.53.2.13

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Azithromycinin the dose of 10 mg/kg and in combination with inhaled tobramycin was suggested for common variable immunodeficiency and bronchiectasis in patients with hyper IgE-syndrome. 2,47 A two week prophylaxis with azithromycin in the dose of 10 mg/kg three times per week is recommended for patients with ataxia-teleangiectasia. 2,48 Bronchiectasis is one of the most severe recurrent respiratory infection complications in patients with hypogammaglobulinaemia.…”

Section: Primary Immunodeficiencymentioning

confidence: 99%

Azithromycin and Co-Trimoxazole in Antimicrobial Prophylaxis: Special Emphasis on Primary Immunodeficiencies in Children

Boyarchuk

2021

Bangladesh J Med Sci

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Patients with primary immunodeficiency diseases (PID) are prone to infectious, and they often determine the course of the disease. Antimicrobial prophylaxis for patients with PID includes co-trimoxazole, amoxicillin and macrolides. Co-trimoxazole is a widely used antimicrobial agent for pneumocystosis prophylaxis in immunocompromised patients, including patients with primary cellular immunodeficiency. Antiinflammatory effect of azithromycin made it a drug of choice in the management of chronic lung diseases in the patients with primary immunodeficiencies, especially in those with antibody deficiencies. Further randomised controlled studies are needed to define the optimal agent for all types of primary immunodeficiencies, its dose, duration of treatment, benefits and safety of long-term use.A recommendation for the prophylactic use of long-term therapy should consider the balance between benefits and risk of adverse events. Bangladesh Journal of Medical Science Vol.20(3) 2021 p.530-538

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Section: Primary Immunodeficiencymentioning

confidence: 99%

Azithromycin and Co-Trimoxazole in Antimicrobial Prophylaxis: Special Emphasis on Primary Immunodeficiencies in Children

Boyarchuk

2021

Bangladesh J Med Sci

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“…According to some epidemiological studies, the use of antibiotics at an early age increases the sensitization of the organism [115], increases the risk of developing allergic diseases, such as asthma, atopic dermatitis, and allergic reactions to cow's milk [116]. An alternative system using antibacterial agents can be inhaled antibiotics in inflammatory respiratory diseases [117,118].…”

Section: Risk Factors For the Development Of Allergy Associated Withmentioning

confidence: 99%

The role of microbiota in the development of allergic diseases

Boyarchuk¹,

CHORNOMYDZ²,

Chornomydz³

et al. 2019

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Scientific progress, industrial development, urbanization, and the "sterile" way of life have a significant negative side, namely, the sustained growth of allergic diseases. The "hygienic theory" is used to explain the unceasing increase in the incidence of allergies in the population. At the same time, an important link in the development of allergic diseases is the microbiological environment and our own microbiota. In our literature review we gathered new data on the pathogenetic relationships between the violation of the quantitative and qualitative composition of our microbiocenosis and the development of allergic diseases. The basic mechanisms by which microbiota influence the development of an allergic process have been established, in particular: influence on T-cell immunity, synthesis of cytokines, etc. In this review, particular attention is paid to factors that lead to microbiocenosis and contribute to the development of allergies. Among them it is worth to highlight inappropriate nutrition, "sterile" style of life, widespread using of antiseptics and antibiotics, etc. Therefore, the most important step in the prevention of allergic diseases is the modification of lifestyle, breastfeeding of children, frequent staying in the open air and contact with nature, rational use of antiseptics and antibiotics.

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Perspectives of the Inhaled Antibiotics Usage in Pediatrics

Cited by 2 publications

References 38 publications

Azithromycin and Co-Trimoxazole in Antimicrobial Prophylaxis: Special Emphasis on Primary Immunodeficiencies in Children

Azithromycin and Co-Trimoxazole in Antimicrobial Prophylaxis: Special Emphasis on Primary Immunodeficiencies in Children

The role of microbiota in the development of allergic diseases

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