An Evidence-Based Review of Efficacy and Safety of Dietary, Natural Supplements and Sunlight in Vitamin D Deficiency

Mak, Jenson

doi:10.5772/intechopen.89598

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Кроме того, недостаток витамина D у детей связан с высоким риском развития артериальной гипертензии, инсулинорезистентности, ожирения и дислипидемии (повышение концентрации общего холестерина и холестерина липопротеинов низкой плотности) [13][14][15]. Основным индуктором эндогенного синтеза витамина D является ультрафиолетовое излучение солнечного света (длина волны 290-320 нм) [16], на который приходится до 50-90% количества витамина D в организме [17], остальная часть поступает с пищей [18,19].…”

Section: обоснованиеunclassified

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Senkevich

Chebargina

Golubkina

2022

Vopr. sovr. pediatr.

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Background. The prevalence of vitamin D deficiency in children by their geographic latitude of residence requires follow-up study. This is crucial for implementation of preventive measures that can reduce the risk of developing pathological conditions associated with vitamin D deficiency.Objective. The aim of the study is to study the vitamin D supplementation of 7–8 years old children living in different geographical latitudes of one subject of Russian Federation.Methods. The study included relatively healthy children living in three geographical areas (northern — 52°, central — 50°, southern — 48°) of one region (Khabarovsk Krai). Vitamin D supplementation was evaluated by 25(OH)D serum concentration via enzyme-linked immunosorbent assay. Vitamin D insufficiency was diagnosed at 25(OH)D concentration of 21–30 ng/ml, deficiency — 10–20 ng/ml, severe deficiency — < 10 ng/ml; optimal 25(OH)D concentration was considered as 30–100 ng/ml.Results. The increase in prevalence of vitamin D deficiency and insufficiency has been revealed with gradual increase from southern (57%) to central (73%) and northern (83%) geographic areas in 7–8 years old children living in the same region. The prevalence of vitamin D deficiency and insufficiency (25(OH)D ≤ 30 ng/mL) among children living in the northern geographic area was greater by 3.8-fold (95% confidence interval 1.2–12.7) then among peers living in the southern areas.Conclusion. One factor affecting 25(OH)D serum concentration in children of this region is the insolation level determined by the geographical latitude of residence. The 4°N difference is significant in determining vitamin D status in residents of relatively high latitudes. Further studies of factors associated with 25(OH)D concentration in children living in different latitudes are required (insolation level, number of sunny days per year, food and household characteristics in families).

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Section: обоснованиеunclassified

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Senkevich

Chebargina

Golubkina

2022

Vopr. sovr. pediatr.

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“…The primary source of vitamin D, 90%, is obtained from the endogenous synthesis of vitamin D3 (cholecalciferol), and the rest is obtained from vitamin D2 (ergocalciferol) food intake. The intake of seafood, margarine, dairy products, and eggs is rich in vitamin D [9][10][11] . Several factors, including endogenous synthesis of vitamin D3, food intake, and supplementation, influence vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

Pengaruh Cholecalciferol 1000 IU pada Kekuatan Genggam Tangan Lansia dengan Defisiensi Vitamin D

Mahargyani,

Probosari,

Candra

et al. 2023

AMNT

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Latar Belakang: Vitamin D berperan pada pengaturan fungsi otot melalui pengikatan antara reseptor vitamin D (VDR) melalui jalur pensinyalan genomik. Bentuk aktif vitamin D (1,25-(OH)D) mempengaruhi otot melalui modulasi transkripsi gen dan jalur pensinyalan kinase protein yang mendukung proliferasi dan pertumbuhan otot. Aging akan menurunkan interaksi vitamin D dan VDR, berpengaruh pada pengaturan saluran kalsium otot yang diikuti penurunan stimulasi kontraksi otot. Penurunan sintesis dan rendahnya asupan vitamin D turut mempengaruhi kadar serum 25(OH)D, sehingga dengan mempertahankan status vitamin D pada lansia dengan defisiensi vitamin D diharapkan menghambat penurunan kekuatan otot dan disfungsi otot. Tujuan: Menganalisis pengaruh pemberian cholecalciferol pada kekuatan genggam tangan. Metode: Sebuah studi eksperimental menggunakan uji coba terkontrol secara acak (RCT) terdiri dari 54 subjek lansia yang terbagi dua kelompok yaitu perlakuan dan kontrol. Kelompok perlakuan menerima cholecalciferol 1000 IU/hari, dan kelompok kontrol mendapat plasebo, selama 12 minggu. Kedua kelompok diperiksa kadar serum 25(OH)D sebelum dan sesudah perlakuan. Hasil: Mayoritas sampel pada kedua kelompok menunjukkan defisiensi vitamin D yaitu sebesar 79,62%. Ada pengaruh suplementasi cholecalciferol 1000 IU terhadap kadar 25(OH)D serum dengan rerata perubahan 3,8 ng/mL (p<0,001), sedangkan terhadap kekuatan genggam tangan menunjukkan hasil yang tidak signifikan dengan rerata perubahan 0,5 kgF (p=0,748). Hubungan perubahan kadar 25(OH)D serum terhadap perubahan kekuatan genggam tangan hasilnya tidak signifikan (r=0,02 dan p= 0,87). Kesimpulan: Pemberian cholecalciferol 1000 IU/hari selama 12 minggu dapat meningkatkan kadar serum vitamin D, namun tidak meningkatkan kekuatan genggam tangan.

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“…Для взрослых с целевым достигнутым уровнем витамина D продолжительность поддерживающей терапии и эффективная поддерживающая терапия не определены. Суточной дозы в 2000 мЕ, по данным ряда исследований, может оказаться недостаточно для достижения таких показателей [8,9], но в некоторых исследованиях оказались эффективными и более низкие дозы (900-1800 мЕ в сутки) [10], что подтверждается опытом отечественных экспертов [11,12] и требует динамического определения концентрации витамина D в клинической практике.…”

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Prevalence of vitamin D level disorders in therapeutic patients and features of their correction

Eliseeva,

Tikhomirova,

Zhdamarova

et al. 2023

Med. vestn. Ûga Ross.

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Objective: to study the prevalence of vitamin D level disorders in therapeutic patients and the features of their correction. Materials and methods: 322 patients who applied for medical help in the field of therapy («rheumatology» and «cardiology») were examined. Materilas and methods: clinical, laboratory (study of the level of vitamin D in the blood), statistical. Results: it was found, that among patients with a therapeutic profile, vitamin D concentration disorders (deficiency and insufficiency) occur in 72.7% of the surveyed. There is a high prevalence of risk factors for osteoporosis in the examined patients: female sex prevails (81%), age (average age was 53.6 ±14.3 years), drug use (50% take proton pump inhibitors, 21.4% take glucocorticoids). When comparing the proportion of people with impaired vitamin D levels in comparison with the data of previous years, there was a decrease in the proportion of people with vitamin D deficiency and an increase in the proportion of people with vitamin D deficiency. Among people with a vitamin D level of 30-100 ng/ml, daily use of vitamin D preparations in dosages exceeding the recommended consumption levels was noted. Conclusion: based on the data obtained, the prevalence of vitamin D deficiency and insufficiency remains high. However, recently there has been a trend towards a decrease in the proportion of people with vitamin D deficiency and an increase in the proportion of people with vitamin D deficiency. In this connection, it is necessary to inform the population about the recommended adequate levels of vitamin D in blood serum and safe dosages of vitamin D preparations for daily intake.

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An Evidence-Based Review of Efficacy and Safety of Dietary, Natural Supplements and Sunlight in Vitamin D Deficiency

Cited by 4 publications

References 30 publications

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Pengaruh Cholecalciferol 1000 IU pada Kekuatan Genggam Tangan Lansia dengan Defisiensi Vitamin D

Prevalence of vitamin D level disorders in therapeutic patients and features of their correction

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