Pengaruh Cholecalciferol 1000 IU pada Kekuatan Genggam Tangan Lansia dengan Defisiensi Vitamin D
Ika Swasti Mahargyani,
Enny Probosari,
Aryu Candra
et al.
Abstract:Latar Belakang: Vitamin D berperan pada pengaturan fungsi otot melalui pengikatan antara reseptor vitamin D (VDR) melalui jalur pensinyalan genomik. Bentuk aktif vitamin D (1,25-(OH)D) mempengaruhi otot melalui modulasi transkripsi gen dan jalur pensinyalan kinase protein yang mendukung proliferasi dan pertumbuhan otot. Aging akan menurunkan interaksi vitamin D dan VDR, berpengaruh pada pengaturan saluran kalsium otot yang diikuti penurunan stimulasi kontraksi otot. Penurunan sintesis dan rendahnya asupan vita… Show more
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