An estrogen treatment may reverse a premature ovarian failure

Pregnancy following diagnosis of premature ovarian insufficiency: a systematic review

“…In 5-10% of cases of POI, however, pregnancy can occur naturally, with hormone replacement therapy (HRT), IVF, or, more recently, in-vitro maturation (IVM) or with stem cell therapy . Numerous case reports also support this statement (TABLE 1) (Check et al, 2000;Nawroth et al, 2000;Zargar et al, 2000;Takahashi et al, 2001;Fernandes, 2002;Hershlag and Schuster 2002;Chao et al, 2003;Eldeen and Fawzi, 2003;Muller et al, 2003;Patel et al, 2003;Aslam et al, 2004;Menezo et al, 2004;Vital-Reyes et al, 2004;Corrigan et al, 2005;Check and Katsoff, 2006;Vandborg and Lauszus, 2006;Liza et al, 2008;Dragojevic-Dikic et al, 2009;Genazzani, 2009;Neves-e-Castro, 2009;Selvaraj et al, 2010;Chen and Chen, 2011;Ebrahimi et al, 2011, Ferrau et al, 2011Laway et al, 2011;Tartagni et al, 2011;Ghazeeri and Awwad, 2012;Grynberg et al, 2013;Maruyama et al, 2013;Soave et al, 2013;Tsuji et al, 2013;Rogenhofer et al, 2014;Warenik-Szymankiewicz and Slopien 2014;Roth and Alvero, 2014;Li et al, 2016).…”

Resumption of ovarian function after 4 years of estro-progestin treatment in a young woman with Crohn’s disease and premature ovarian insufficiency: a case report

“…We think that this case report may suggest, together with previous demonstrations [18], that estro-progestin treatment might be proven in POI women, even in cases with highly elevated gonadotropin serum levels, before telling them that they are definitely sterile.…”

“…1), but the ovarian responsiveness, as expressed by normal ovarian volume and by ovulatory follicles at ultrasound, as well as by the re-establishment of regular menses after estro-progestin discontinuation, was achieved after 4 years of treatment. In most reported cases the ovulatory response occurs after 2 to 8 months course of estro-progestin therapy [1,17], though 2 years of treatment have been found to be necessary in one case [18]. Indeed, follicle-like structures were demonstrated by ultrasound in earlier follow-up visits (see Table 1), but they weren't likely to demonstrate a functional ovarian activity.…”