An Epidemio-Clinical and Histo-Pathological Study of Lichen Planus

Gupta, Sanjeev; Talanikar, Hemant; Ghadgepatil, Shruti S

doi:10.14260/jemds/2016/1503

Cited by 2 publications

(4 citation statements)

References 8 publications

(7 reference statements)

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“…Similarly in studies of lichen planus lesions also, Gurusamy et al [15] , Karumbaiah et al [16] and Parihar et al [9] showed 100% association with vacuolar degeneration of the basal layer. Presence of band like inflammatory infiltrates (Figure-3) in the interface was reported in 92%, 94%, 82.36% of lichen planus lesions by Gupta et al [14] , Parihar et al [9] and Karumbaiah et al [16] respectively. Our study showed 92.5% of cases with interface inflammation, with a high fraction of them (60%) showing inflammation both in interface and perivascular foci rather than strict interface inflammation (30%).…”

Section: Discussionmentioning

confidence: 92%

“…Present study showed 77.5% of cases of lichen planus showing hypergranulosis. Gupta et al [14] , Parihar et al [9] , Gurusamy et al [15] and Karumbaiah et al [16] showed hypergranulosis of 86%, 96.5%, 80% and 76.47% respectively in their study of lichen planus. Prominent granular layer is considered to be the cause of Wickham's striae seen in clinical lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly Parihar et al [9] noted 94% of lichen planus lesions showing acanthosis. Gupta et al [14] and Gurusamy et al [15] recorded 88% and 78% of acanthosis in lichen planus cases respectively.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

Priya

Devi

Karthikeyan

et al. 2018

APALM

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Background: Besides lichen planus various other skin lesions like erythema multiforme, pityriasis lichenoides, etc., show lichenoid reaction pattern. This study was aimed to compare the histological features and number of mast cells in cutaneous lichen planus and lichenoid lesions. Studies have shown increase in mast cell numbers in mucosal lichen planus and lichenoid lesions. Methods: Tissue sections of lichen planus and lichenoid lesions, (forty samples for each group) were studied. All the epidermal, dermal changes and mast cell numbers were noted. Results: Epidermal and dermal changes like acanthosis, hypergranulosis, hyperkeratosis, location of inflammatory cells, severity of inflammation and basement membrane thickness were statistically significant between the two groups. Cases with severe inflammation showed thin and disrupted basement membrane, severe capillary proliferation and severe basal cell vacuolation. The number of mast cells was not significant on comparison between the two groups. Conclusion: The epidermal and dermal changes were consistent with usual histopathological findings in these lesions. The mast cell number was not significant on comparison, which may be due to the common and overlapping mechanisms in the pathogenesis of inflammation in both the groups.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

Priya

Devi

Karthikeyan

et al. 2018

APALM

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“…In 7,12 Our study also had five cases in the pediatric age group. Kanwar and De conducted a study on pediatric cases which showed a prevalence of 5% among the outpatients who visited their department.…”

Section: Discussionmentioning

confidence: 99%

Histomorphological study of lichenoid dermatitides – A retrospective study

et al. 2023

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Background: Lichenoid dermatitis is a very common dermatological condition and is defined by features of basal cell damage and a dense band-like infiltration at the dermo-epidermal junction. There is a wide range of lesions included under this and the prototype lesion is Lichen Planus. Aims and Objectives: The aims of this study were to study the histopathological spectrum of the conditions with lichenoid tissue reaction and to find clinicopathological concordance of the lichenoid lesions. Materials and Methods: A retrospective study was conducted in a tertiary care center, where all the skin biopsy cases diagnosed clinically and/or histologically as lichenoid dermatitis for 2 years (2018–2019) were included in the study. Demographic details, clinical diagnosis, histological diagnosis, and the different histological features were collected from the respective case sheets and biopsy reports and entered in an excel worksheet. Frequency and percentages were used to represent the data. Results: A total of 47 cases were clinically diagnosed as lichenoid dermatitis, of which 38 cases showed concordance between clinical and histopathological diagnosis. Nine cases showed discordance between clinical and histopathological diagnosis and were categorized as lesions without lichenoid features. Seven cases were diagnosed as lichenoid dermatitis only on the histopathological study with an absence of such a differential diagnosis clinically. Out of the total 45 cases diagnosed as lichenoid dermatitis, 27 were lichen planus, five were lichen planus pigmentosus, four were hypertrophic lichen planus, three were lichenoid dermatitis, and two cases each of lichen planopilaris, lichen keratosis, and lichen sclerosis. Lichenoid dermatitis was seen commonly among the 41–50 years age group. Females were more commonly affected than males. Conclusion: Lichen planus is the prototype lesion among the lichenoid dermatitides. Definitive diagnosis of the specific entity among the lichenoid lesions is important as decision-making regarding the treatment modality and prognosis of the patient depends on it. Histopathological examination is vital for the definitive diagnosis, along with clinical correlation which concludes that clinicopathological correlation is the key.

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An Epidemio-Clinical and Histo-Pathological Study of Lichen Planus

Abstract: BACKGROUNDLichen planus, a unique cutaneous entity, consists of distinct gross-colour, configuration, pattern, location, appearance -as well as microscopic features. The aim of this study was to assess of epidemiological, clinical and histopathological correlation of lichen planus.

Cited by 2 publications

References 8 publications

Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

Histomorphological study of lichenoid dermatitides – A retrospective study

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