Background: Besides lichen planus various other skin lesions like erythema multiforme, pityriasis lichenoides, etc., show lichenoid reaction pattern. This study was aimed to compare the histological features and number of mast cells in cutaneous lichen planus and lichenoid lesions. Studies have shown increase in mast cell numbers in mucosal lichen planus and lichenoid lesions. Methods: Tissue sections of lichen planus and lichenoid lesions, (forty samples for each group) were studied. All the epidermal, dermal changes and mast cell numbers were noted. Results: Epidermal and dermal changes like acanthosis, hypergranulosis, hyperkeratosis, location of inflammatory cells, severity of inflammation and basement membrane thickness were statistically significant between the two groups. Cases with severe inflammation showed thin and disrupted basement membrane, severe capillary proliferation and severe basal cell vacuolation. The number of mast cells was not significant on comparison between the two groups. Conclusion: The epidermal and dermal changes were consistent with usual histopathological findings in these lesions. The mast cell number was not significant on comparison, which may be due to the common and overlapping mechanisms in the pathogenesis of inflammation in both the groups.
<p class="abstract"><strong>Background:</strong> <span lang="EN-GB">Dermatological manifestations can be a window to the clinical and immunological status of patients with HIV infection. Introduction of HAART has dramatically shifted the pattern of HIV associated dermatoses. The present study has been carried out to find out the same among HIV infected patients not started on HAART therapy</span><span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Two hundred (200) HIV-positive, HAART-naïve patients attending ART centre of excellence were examined between November 2005 to July 2007, for the presence of mucocutaneous manifestations, correlation with CD4 count and analyzed using SPSS software</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Out of the 200 patients examined, 64.5% (n=129) were found to have mucocutaneous manifestations. Out of those 129 patients 70 (54.3%) were male and 59 (45.7%) were females. Age of the patients ranged from 5 to 62 years with a mean±S.D of 32.08±11.48 yrs. Fungal infections (n=67, 51.9%) were the most common infectious dermatoses, followed by viral infections (n=35, 27.1%), scabies infestations (n=17, 13.2%) and bacterial infections (n=2, 1.6%). Of all the fungal infections, candidiasis (43.28%) was the commonest. Majority (64.5%) of the mucocutaneous manifestations were seen in patients with CD4 count <200 cells/mm<sup>3</sup> and difference in CD4 count was significantly associated with cutaneous penicilliosis and oral hairy leukoplakia (p<0.044). </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Infectious dermatoses remain as the far most common skin manifestations in HAART naïve patients. Lower the CD4 higher will be the incidence. Rare endemic infections like penicilliosis should be considered in differentials of umbulicated lesions in this part of the country.</span></p>
Investigations revealed raised ESR 75 mm/h (Westergren), Mantoux test was strongly positive with induration of 30 mm X 30 mm. Biopsy from the lesion on the face ABSTRACT A 35-year-old male presented with recurrent crops of papules and plaques over extensor surface of forearm, elbow, back, face, neck and lower back side of trunk since two months, along with multiple cervical lymphadenopathy over the right side of neck. On the basis of clinic pathological findings and its response to the treatment the diagnosis of papulonecrotic tuberculid (PNT) was made.
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