An enzyme-free Ti3C2/Ni/Sm-LDH-based screen-printed-electrode for real-time sweat detection of glucose

Gilnezhad, Javad; Firoozbakhtian, Ali; Hosseini, Morteza; Adel, Sadra; Xu, Guobao; Ganjali, Mohammad Reza

doi:10.1016/j.aca.2023.340981

Cited by 25 publications

(10 citation statements)

References 62 publications

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“…Hosseini et al fabricated a Ti3C2/nickel-samarium-layered double hydroxide for enzyme-free real-time glucose detection. The glucose sensing was investigated with the DPV method, resulting in a LOD value of 0.24 µM and a linear range from 0.001 to 0.1 mM and 0.25-7.5 Mm [182]. Li et al demonstrated a highly integrated wearable sensing paper (HIWSP) for electrochemical analysis of glucose and lactate from sweat [183].…”

Section: Glucose Sensingmentioning

confidence: 99%

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Ganesan,

Ramajayam,

Kokulnathan

et al. 2023

Molecules

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Sweat, a biofluid secreted naturally from the eccrine glands of the human body, is rich in several electrolytes, metabolites, biomolecules, and even xenobiotics that enter the body through other means. Recent studies indicate a high correlation between the analytes’ concentrations in the sweat and the blood, opening up sweat as a medium for disease diagnosis and other general health monitoring applications. However, low concentration of analytes in sweat is a significant limitation, requiring high-performing sensors for this application. Electrochemical sensors, due to their high sensitivity, low cost, and miniaturization, play a crucial role in realizing the potential of sweat as a key sensing medium. MXenes, recently developed anisotropic two-dimensional atomic-layered nanomaterials composed of early transition metal carbides or nitrides, are currently being explored as a material of choice for electrochemical sensors. Their large surface area, tunable electrical properties, excellent mechanical strength, good dispersibility, and biocompatibility make them attractive for bio-electrochemical sensing platforms. This review presents the recent progress made in MXene-based bio-electrochemical sensors such as wearable, implantable, and microfluidic sensors and their applications in disease diagnosis and developing point-of-care sensing platforms. Finally, the paper discusses the challenges and limitations of MXenes as a material of choice in bio-electrochemical sensors and future perspectives on this exciting material for sweat-sensing applications.

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Section: Glucose Sensingmentioning

confidence: 99%

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Ganesan,

Ramajayam,

Kokulnathan

et al. 2023

Molecules

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“…In recent times, the exploration of MXenes, a class of intriguing two-dimensional structures, has emerged as a prominent avenue in electrochemical research. , Particularly, the modification of electrode surfaces using these MXene structures, pioneered by the esteemed Gogotsi and his team, has attracted significant attention. The enthusiasm for MXenes stems from their exceptional qualities, which include outstanding electron conductivity, impressive ion adsorption capabilities, notable stability, distinctive structure, and exceptional mechanical properties . These remarkable characteristics have positioned MXenes as highly favored materials in ECL assays. , The unique properties of MXenes contribute to their efficacy and enable their application in sensitive and efficient ECL-based analytical techniques, further solidifying their significance in the field of electrochemical investigations …”

Section: Introductionmentioning

confidence: 99%

“…The enthusiasm for MXenes stems from their exceptional qualities, which include outstanding electron conductivity, impressive ion adsorption capabilities, notable stability, distinctive structure, and exceptional mechanical properties. 19 These remarkable characteristics have positioned MXenes as highly favored materials in ECL assays. 20,21 The unique properties of MXenes contribute to their efficacy and enable their application in sensitive and efficient ECL-based analytical techniques, further solidifying their significance in the field of electrochemical investigations.…”

Section: ■ Introductionmentioning

confidence: 99%

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

Firoozbakhtian,

Hosseini,

Guan

et al. 2023

Anal. Chem.

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Point-of-care testing plays a crucial role in diagnostics within resourcepoor areas, necessitating the utilization of portable and user-friendly devices. The adaptation of biosensors for point-of-care applications requires careful considerations, such as miniaturization, cost-effectiveness, and streamlined sample processing. In recent years, the electrochemiluminescence (ECL) immunoassay has gained significant attention due to its visual detection capabilities and ability to facilitate high-throughput analysis. However, the development of a practical and cost-effective ECL device remains a challenging task. This study presents the development of an integrated MXenemodified single-electrode electrochemical system (SEES) for visual and high-throughput ECL immunoassays incorporating a Raspberry Pi system. The SEES was designed by affixing a plastic sticker with multiple perforations onto a single carbon ink screenprinted electrode, which operates based on a resistance-induced potential difference. Leveraging the excellent adsorption and bioaffinity properties of the carbon ink screenprinted electrode, effective immobilization of antibodies was achieved. Furthermore, the incorporation of Co−Pt nanoparticles enhanced the ECL intensity and electron transfer kinetics, enabling the sensitive detection of SARS-CoV-2. The developed system comprised 18 individual reaction cells, allowing for simultaneous analysis while maintaining sample isolation. Impressively, the system achieved a remarkable minimum virus detection limit of 10 −14 g mL −1 , accompanied by a high R 2 value of 0.9798. These findings highlight the promising potential of our developed system for efficient point-of-care testing in resource-limited settings.

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“…The blood glucose level of normal people ranges from 4.4 to 6.6 mmol L −1 . If blood glucose levels exceed this range, it can lead not only to diabetes, but also to more serious complications that can seriously damage a person’s health [ 2 ]. Based on the recent report of International Diabetes Federation (IDF) in 2021, over 537 million adults are suffering from diabetes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Research Progress on Biomimetic Nanomaterials for Electrochemical Glucose Sensors

Chi

Zhang

et al. 2023

Biomimetics

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Diabetes has become a chronic disease that necessitates timely and accurate detection. Among various detection methods, electrochemical glucose sensors have attracted much attention because of low cost, real-time detection, and simple and easy operation. Nonenzymatic biomimetic nanomaterials are the vital part in electrochemical glucose sensors. This review article summarizes the methods to enhance the glucose sensing performance of noble metal, transition metal oxides, and carbon-based materials and introduces biomimetic nanomaterials used in noninvasive glucose detection in sweat, tear, urine, and saliva. Based on these, this review provides the foundation for noninvasive determination of trace glucose for diabetic patients in the future.

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An enzyme-free Ti3C2/Ni/Sm-LDH-based screen-printed-electrode for real-time sweat detection of glucose

Cited by 25 publications

References 62 publications

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

Research Progress on Biomimetic Nanomaterials for Electrochemical Glucose Sensors

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An enzyme-free Ti3C2/Ni/Sm-LDH-based screen-printed-electrode for real-time sweat detection of glucose

Cited by 25 publications

References 62 publications

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Recent Advances in Two-Dimensional MXene-Based Electrochemical Biosensors for Sweat Analysis

Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti3C2 MXene-Modified Single Electrode Electrochemical System on Raspberry Pi

Research Progress on Biomimetic Nanomaterials for Electrochemical Glucose Sensors

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Product

Resources

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Boosting Electrochemiluminescence Immunoassay Sensitivity via Co–Pt Nanoparticles within a Ti₃C₂ MXene-Modified Single Electrode Electrochemical System on Raspberry Pi