An electrochemical method for the determination of liposome–water partition coefficients of drugs

Ikonen, Marjukka; Murtomäki, Lasse; Kontturi, Kyösti

doi:10.1016/j.jelechem.2006.12.014

Cited by 31 publications

(22 citation statements)

References 18 publications

(20 reference statements)

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“…Square wave voltammetry was applied for the determination of the liposome-water partition coefficients of b-blockers (pro-panolol, timolol, carteolol, nadolol and metrorolol). It was established that both the composition and volume of the liposomes and the chemical structure of the bioactive compounds influence the partition coefficients (Ikonen et al, 2007). Fluorescence technique has also found application in liposome research.…”

Section: Other Investigation Methodsmentioning

confidence: 99%

Liposomes in chromatography

Cserháti

Szőgyi

2010

Biomedical Chromatography

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The newest achievements in the application of liposomes in different chromatographic technologies such as high-performance liquid chromatography and electrically driven separation methods was compiled and critically evaluated. The employment of chromatographic methodologies for the determination of molecular parameters of biological importance is also discussed in detail. The future trends of the use of liposomes is also shortly discussed.

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Section: Other Investigation Methodsmentioning

confidence: 99%

Liposomes in chromatography

Cserháti

Szőgyi

2010

Biomedical Chromatography

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“…15 It is an important physical parameter of transportation of drug into biological membrane. Generally speaking, it is easy for drug with the larger partition coefficient to penetrate into the biological membrane and be absorbed.…”

Section: Partition Of Binol Into Liposomal Bilayer Membranementioning

confidence: 99%

Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome

Chen¹,

Gan²,

An³

et al. 2010

Chin. J. Chem.

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The interaction between (1,1'-binaphthalene)-2,2'-diol (BINOL) and lecithin liposome was studied by UV-Vis, fluorescence and 1 H NMR spectroscopies. BINOL can obviously associate with lecithin liposome and the preferential binding site of BINOL with lecithin liposome is located in the headgroup region. The hydrogen bond and electrostatic interaction should exist in BINOL/liposome system, which restricts intra-annular rotation of naphthol moieties. Therefore, the fluorescence intensity of BINOL increases when a small quantity of liposome is added into the system. The partition coefficient K D between the lecithin liposome and the aqueous phase is 310.9. With the increase of BINOL concentration, the micropolarity (I 1 /I 3 ) and membrane fluidity of liposome decreased, while the viscosity of membrane increased.

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“…Although nafarelin is more lipophilic than LHRH, their membrane activities have been found to be in divergence. Kontturi et al [57] have reported the liposome-water partition coefficients of several -blockers (carteolol, metoprolol, nadolol, propranolol, and timolol) resulting form the interactions between the protonated drugs and dipalmitoyl phosphatidylcholines (DPPC) studied by voltammetry at liquid-liquid interface in a micropipette set-up. DPPC has also been used in the membrane interaction electrochemical studies of several protonated polyammonium antifungal agents at a modified waternitrobenzene interface [58].…”

Section: N O T F O R D I S T R I B U T I O Nmentioning

confidence: 99%

Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements

Gulaboski¹,

Borges²,

Pereira³

et al. 2007

CCHTS

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Abstract:The latest results of voltammetric research on the ionic transfer process of ionisable drugs across bare and lipid-modified liquid-liquid interfaces are reviewed. In recent years, two voltammetric methods have been extensively applied to this purpose, i.e. the classical four electrode voltammetry at the interface between two immiscible electrolyte solutions, and the "three-phase electrode." Thus, a brief background of the methodologies and some successful examples of their application are highlighted in this work. Particular attention is given to the ionic transfer kinetics and to the electrochemical characterization of the drug-membrane interactions between the ionized drugs and lipid-modified interfaces. Future trends in this area are also mentioned in connection with high-throughput assessment of ADMET properties of drugs.

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An electrochemical method for the determination of liposome–water partition coefficients of drugs

Cited by 31 publications

References 18 publications

Liposomes in chromatography

Liposomes in chromatography

Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome

Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements

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