An elastic gel consisting of natural polyphenol and pluronic for simultaneous dura sealing and treatment of spinal cord injury

Wang, Yu; Xie, Changnan; Wang, Peng; Wang, Xinyu; Wang, Changping; Xun, Xiaojie; Lin, Chaowei; Huang, Zhihui; Cheng, Yiyun; Li, Lei; Teng, Hui

doi:10.1016/j.jconrel.2020.04.042

Cited by 28 publications

(31 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thanks to the antibacterial, antiinflammatory, antioxidant, and anticancer properties as well as the universal adhesion capability of natural tea polyphenols, polyphenols are fast becoming a popular class of molecules that are attracting more researchers to build various materials for bioimaging, therapeutic delivery, and other biomedical applications. [236][237][238][239][240][241][242][243][244][245][246][247][248][249][250][251] Moreover, inspired by the coordination interactions between various metal ions and polyphenols, researchers have also provided a number of functional MPNs to engineer multifunctional nanosystems. [252][253][254][255][256][257][258][259] Here, we have reviewed the structures and classification of natural polyphenols, the synthesis and properties of the polyphenol-containing nanomaterials, and various biomedical applications of polyphenol-based nanosystems.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

View full text Add to dashboard Cite

Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…192 Several poloxamers are commercially available, differing in composition and molar mass (MM). 34,[192][193][194] The most commonly used poloxamer in TRG-related studies is poloxamer 407 (Pluronic® F127, MM ≈ 12.6 kg mol −1 and EG 70 wt%), 6,[43][44][45][46][47][48][49][50][51][52][53][54][55][56]195,196 as this poloxamer gels at lower temperatures and concentrations compared to the other members of the family. 34 More specifically, it has been reported that poloxamer 407 gels at 12.6 w/v% in phosphate buffered saline (PBS), when purified appropriately, while gelation is not observed when the concentration is reduced to 11.6 w/v%.…”

Section: Poloxamer Basedmentioning

confidence: 99%

“…without any polymer additives that would act as gelation modifiers, were applied in vivo have been reported in the literature. 6,[43][44][45][46][47][48][49][50][51][52][53][54][55][56]195,196 Most of the studies have used solutions of poloxamer 407 at 20 w/w% and higher, due to the higher stability and strength of the gel; however, a few studies have attempted the application at 15 w/w%. In TE, the gel was used to replace the nucleus pulposus, which acts as a shock absorber, in the intervertebral disc in dogs, and it was proven to be effective in resisting the strain applied for at least a period of 3 months.…”

Section: Poloxamer Basedmentioning

confidence: 99%

“…44 In another study, bone mesenchymal stromal cells (BMSC) and chondrocytes were incorporated in the gel matrix, and the TRG system led to chondrogenic differentiation of BMSC. 43 In the drug delivery concept, solutions of P407 were investigated in vivo as carriers for HIV-1 lentiviral vector, 56 quetiapine fumarate, 55 latanoprost, 196 paclitaxel (PTX), 54 lapatinib, 54 vancomycin, 53 brimonidine tartrate, 51,52 rapamycin, 50 halobetasol propionate, 49 polyphenol tannic acid, 48 dapsone, 6 soy isoflavone, 47 RNA polymerase I inhibitor 46 and simvastatin. 45 This indicates the wide variety of diseases, ranging from cancer 50,54 to chronic otitis, 53 ocularrelated diseases, 51,52 acne, 6 intimal hyperplasia 45 and wound healing, 6,47,48 for which TRGs have been in vivo tested as drug delivery carriers.…”

Section: Poloxamer Basedmentioning

confidence: 99%

“…43 In the drug delivery concept, solutions of P407 were investigated in vivo as carriers for HIV-1 lentiviral vector, 56 quetiapine fumarate, 55 latanoprost, 196 paclitaxel (PTX), 54 lapatinib, 54 vancomycin, 53 brimonidine tartrate, 51,52 rapamycin, 50 halobetasol propionate, 49 polyphenol tannic acid, 48 dapsone, 6 soy isoflavone, 47 RNA polymerase I inhibitor 46 and simvastatin. 45 This indicates the wide variety of diseases, ranging from cancer 50,54 to chronic otitis, 53 ocularrelated diseases, 51,52 acne, 6 intimal hyperplasia 45 and wound healing, 6,47,48 for which TRGs have been in vivo tested as drug delivery carriers. It also highlights the great potential of these gel matrices in biomedical engineering, as it has been observed that incorporation of the drugs in the gel depots provides local release 52,53 and controls the drug release rate.…”

Section: Poloxamer Basedmentioning

confidence: 99%

See 2 more Smart Citations

Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Constantinou

Georgiou

2021

Polymer International

View full text Add to dashboard Cite

Thermoreversible polymer hydrogels (TRGs) are physical aqueous networks triggered by temperature that find potential applications in tissue engineering (TE) and drug/gene delivery. When systems with lower critical solution temperature (LCST) behaviour are used, the aqueous solution of polymer is mixed with cells or drugs/genes, depending on the desired application, at room temperature and then injected in vivo to form a hydrogel. This in situ forming hydrogel acts as a matrix for tissue regeneration or controlled and targeted release of the compound. This review focuses on discussing the studies in which synthetic TRGs with LCST behaviour have been applied in vivo in model animals. These studies are categorised depending on the general structure of the polymer, as follows: (i) poloxamers (also known as Pluronics®), (ii) degradable polymers, (iii) poly(N-isopropylacrylamide), (iv) poly(organophosphazene) and (v) poly(2-ethyl-2-oxazoline). In general, when the system is optimised, TRGs provide sustained and topical release of the drugs, thus minimising the undesired side effects. When applied in the TE field, tissue formation was observed. Interestingly, two polymers have reached clinical trials, namely poloxamer 407 (P407, Pluronic® F127, often combined with P188, F68) and Regel® (the formulation of Regel® with the anticancer agent paclitaxel is known as Oncogel®), indicating the challenges that need to be overcome before successful application in clinics.

show abstract

Biomaterial‐Based Defenders Boost Biopharmaceuticals Efficacy for Spinal Cord Injury Treatment: A Review

Zhang

Cao

2023

Adv Materials Inter

View full text Add to dashboard Cite

Spinal cord injury (SCI) has seriously affected the lives of patients and brought economic and medical burdens to society. Biopharmaceuticals, including transplanted cells, growth factors, enzyme drugs, and microRNA, present multidimensional therapeutic effects in tissue repair and regeneration, and thus are widely utilized for the treatment of SCI. Nevertheless, they still encounter great challenges. The turbulent microenvironment accompanied by various destructive components following SCI has led to poor stability, low local accumulation, and reduced therapeutic efficacy of biopharmaceuticals. To this end, biomaterial‐based defenders (BBDs) that are capable of resisting the destructive components have shown great promise in improving the survival of transplanted cells or retaining the activity of the protein and nucleic acid drugs for the treatment of SCI. In this review, various types of biopharmaceuticals applied in SCI and their limitations are introduced. The destructive components that threaten the activities of biopharmaceuticals in the rigorous microenvironment are then summarized. In particular, the current research progress about BBDs boosting the efficacy of biopharmaceuticals for the treatment of SCI is illustrated with specific examples. The existing challenges and future perspectives are also provided.

show abstract

An elastic gel consisting of natural polyphenol and pluronic for simultaneous dura sealing and treatment of spinal cord injury

Cited by 28 publications

References 51 publications

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Biomaterial‐Based Defenders Boost Biopharmaceuticals Efficacy for Spinal Cord Injury Treatment: A Review

Contact Info

Product

Resources

About