An efficient approach to endow TiNbTaZr implant with osteogenic differentiation and antibacterial activity in vitro

Fang, Yingjing; Wang, Qingge; Yang, Zhi; Yang, Wenyue; Wang, Liqiang; Ma, Jing; Fu, Yuanfei

doi:10.1016/j.matdes.2022.110987

Cited by 11 publications

(3 citation statements)

References 72 publications

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“…It indicated that appropriate Ag + concentration provide an advantageous condition for osteogenic differentiation at an early stage, while the promotion was decreased at late stage. The reason was mainly attributed to the conversion from ALP to mineralization, which was also proved by previous studies [39][40][41]. In addition, the quantity of mineralization of cells after culturing for 14 d is lower than that for 7d, which was attributed to the sustained Ag + release and decreased cell viability for the next 7d.…”

supporting

confidence: 57%

“…The reason was mainly attributed to the conversion from ALP to mineralization, which was also proved by previous studies. [39][40][41] In addition, the quantity of mineralization of cells after culturing for 14 d is lower than that for 7d, which was attributed to the sustained Ag + release and decreased cell viability for the next 7d. Previous study reported that the introduce of Ag nanoparticles may had almost no influence on osteogenic differentiation on the first 3d, while the sustained silver ion release would have negative effect on mineralization after 7d.…”

Section: Osteogenic Differentiation Evaluationmentioning

confidence: 99%

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Fabrication and evaluation of silver modified micro/nano structured titanium implant

Huang,

Wang,

Yao

et al. 2024

J Biomater Appl

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In order to enhance the antibacterial property of titanium implant without inducing obvious cytotoxicity, the combination of Ag nanolayer and micro/nano surface structure was conducted by magnetron sputtering and hot-alkali treatment in this study. A series of specimens (AH-Ti, AH-Ti/Ag0.25, AH-Ti/Ag1, AH-Ti/Ag2, and AH-Ti/Ag5) were prepared with different sputtering durations (0 min, 0.25 min, 1 min, 2 min, 5 min), respectively, all realizing long-term release of Ag+. In vitro experiments indicated that AH-Ti/Ag1 group possessed good cytocompatibility, nice osteogenic ability, and excellent antibacterial efficiency as well. In addition, AH-Ti/Ag0.25 showed good biocompatibility, while the reduction of S.aureus (78.5%) was not enough compared with AH-Ti/Ag1. Although the AH-Ti/Ag2 and AH-Ti/Ag5 group showed superior antibacterial activity, their obvious cytotoxicity caused low ALP and mineralization level. Therefore, the design of suitable Ag nanolayer coating combined with micro/nano surface structure (AH-Ti/Ag1) might be a promising strategy to enhance osteogenic property and maintain excellent antibacterial ability at the same time.

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supporting

confidence: 57%

Section: Osteogenic Differentiation Evaluationmentioning

confidence: 99%

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Huang,

Wang,

Yao

et al. 2024

J Biomater Appl

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“…Surface modification can optimize the micro/nanotopography and composition of the implant surface, which can effectively improve the roughness and hydrophilicity of the implant, facilitate the binding of osteoblasts with the implant, and promote osseointegration. On the other hand, modification of antibacterial components on the surface of Ti implants can effectively inhibit bacterial proliferation and avoid inflammation. − Appropriate surface modification techniques can effectively achieve the desired goals. In this Review, we systematically review the development of the latest surface modification techniques of Ti dental implants.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification and Functionalities for Titanium Dental Implants

Sun,

Liu,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

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Dental implants have become the mainstream strategy for oral restoration, and implant materials are the most important research hot spot in this field. So far, Ti implants dominate all kinds of implants. The surface properties of the Ti implant play decisive roles in osseointegration and antibacterial performance. Surface modifications can significantly change the surface micro/nanotopography and composition of Ti implants, which will effectively improve their hydrophilicity, mechanical properties, osseointegration performance, antibacterial performance, etc. These optimizations will thus improve implant success and service life. In this paper, the latest surface modification techniques of Ti dental implants are systematically and comprehensively reviewed. The various biomedical functionalities of surface modifications are discussed in-depth. Finally, a profound comment on the challenges and opportunities of this frontier is proposed, and the most promising directions for the future were explored.

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A study of bionics micro-textures on the surface of HA bio-coatings prepared by nanosecond laser

Zhang

Zhou

2023

Ceramics International

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An efficient approach to endow TiNbTaZr implant with osteogenic differentiation and antibacterial activity in vitro

Cited by 11 publications

References 72 publications

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Surface Modification and Functionalities for Titanium Dental Implants

A study of bionics micro-textures on the surface of HA bio-coatings prepared by nanosecond laser

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