Background: China has made good progress in its medical reform but challenges remain. In this paper, we proposed a multi-tiered electrocardiogram (ECG) network system to solve the problems of traditional ECG monitoring. Methods: We discussed the current situation and insufficiencies of ECG examination and constructed an ECG network system. The proposed ECG network system consisted of nosocomial ECG system combined with hospital information system and electronic medical record system, WEB-based ECG network system for the regional medical association system, and 120 pre-hospital first-aid ECG system based on 4G mobile network. The ECG network system has initially applied for clinical monitoring and diagnosis for 5 years. Results: Our application results showed that the ECG network system had high efficiency and practicability under the current medical environment, which provided a reliable basis for clinical rapid and definite diagnosis, and partially solved the imbalance of the medical resources among regional medical institutions. Conclusion: It has great significance for the management and remote consultation of heart disease and provides a reference for exploring the reform of clinical data sharing and improving the efficiency of medical resource integration.