An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor (ADRB2) gene with risk of asthma in children

Guo, Xingqing; Zheng, Hao; Mao, Chenggang; Guan, Enben

doi:10.12932/ap0597.34.1.2016

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…[ 81 ] CTLA-4 can improve airway hyperresponsiveness and plays an important role in the pathogenesis of asthma. [ 82 ] Our results and Guo et al [ 83 ] found -46 G/A and -79G/C polymorphisms of ADRB2 gene were not associated with a risk of childhood asthma. However, some studies [ 84 , 85 ] indicated that -79G/C polymorphism was associated with a reduced risk for the development of pediatric asthma.…”

Section: Discussionsupporting

confidence: 58%

Asthma susceptible genes in children

et al. 2020

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Section: Discussionsupporting

confidence: 58%

Asthma susceptible genes in children

et al. 2020

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“…Initially, there were 386 potentially relevant publications identified during the literature search. Following primary screening using the study exclusion criteria, a total of 167 publications were eliminated, which resulted in a total of 18 controlled studies that included 2,982 pediatric patients with asthma and 2,651 controls [10,15–17,22–35]. The main findings of each study are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Previously published controlled clinical have investigated the role of the ADRB2 gene and the gene polymorphisms in the susceptibility to asthma in pediatric patients [10,15–17]. However, these studies have reported inconsistent findings, because of the small number of study participants, the presence of clinical heterogeneity, or due to a combination of both factors.…”

Section: Introductionmentioning

confidence: 99%

The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature

Zhang

Zhu

2019

Med Sci Monit

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Background The ADRB2 gene encodes the β2-adrenergic receptor (β2-AR). This study aimed to determine the association between the C79G polymorphism of the ADRB2 gene and its association with pediatric asthma using a meta-analysis of the published data. Material/Methods Review of publications up to May 2018 was from the PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and WanFang databases. The odds ratio (ORs) with 95% confidence interval (CI) were used in evaluating the strength of the reported association between the C79G polymorphism of the ADRB2 gene and pediatric asthma. Results There were 18 controlled studies that included 2,982 pediatric cases of asthma and 2,651 controls. Expression of the C79G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs . CC: OR, 0.69; 95% CI, 0.55–0.88) and the recessive model (GG vs . CC+CG: OR, 0.65; 95% CI, 0.53–0.81). Subgroup analysis by ethnicity showed a significantly reduced risk of pediatric asthma in Asian patients for comparison of the co-dominant model (GG vs . CC: OR, 0.59; 95% CI, 0.45–0.78), the recessive model (GG vs . CC+CG: OR, 0.58; 95% CI, 0.45–0.76), and the allelic model (G vs . C: OR, 0.89; 95% CI, 0.79–0.99). Conclusions The C79G polymorphism of the ADRB2 gene encoding β2-AR was associated with a reduced risk for the development of pediatric asthma, particularly in the Asian population.

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“…At present, the β 2 -AR gene polymorphisms are associated with individual predisposition to airway hyperreactivity and asthma, variability in response to β 2 -agonists, and the development of resistance to their bronchodilator effect. The link between the Gln27Glu polymorphism in the β 2 -AR gene and the risk of asthma, which was proven in numerous studies, still relates to contradictory and sometimes opposite results in other studies [4][5][6].…”

mentioning

confidence: 98%

“…The most extensively studied and common polymorphic variants of the β 2 -AR gene are Gln27Glu, Arg16Glu, and Thr164lle, which determine the functional features of the receptor associated with asthma phenotypes and the effectiveness of β 2 -agonist treatment [1-3].At present, the β 2 -AR gene polymorphisms are associated with individual predisposition to airway hyperreactivity and asthma, variability in response to β 2 -agonists, and the development of resistance to their bronchodilator effect. The link between the Gln27Glu polymorphism in the β 2 -AR gene and the risk of asthma, which was proven in numerous studies, still relates to contradictory and sometimes opposite results in other studies [4][5][6].Some papers, especially concerning pediatric asthma, also demonstrated that the Gln27Glu polymorphism in the β 2 -AR gene was not associated with a higher risk of asthma in different ethnic groups within general population…”

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confidence: 99%

GLN27GLU polymorphism in the β2-adrenergic receptor gene in patients with bronchial asthma

Kachkovska

2022

ZMJ

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The aim of the study was to analyze the frequency of the polymorphism in the β2-adrenoceptor (Gln27Glu) gene in patients with bronchial asthma (BA) and to assess the association of the polymorphism with disease risks. Materials and methods. A total of 553 patients with BA and 95 apparently healthy individuals were examined. The Gln27Glu polymorphism in the β2-АR gene (rs1042714) was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Statistical analysis of the results was performed using SPSS-17 program. Results. The allele and genotype distribution of the Gln27Glu polymorphism in the β2-АR gene in apparently healthy individuals and BA patients was consistent with Hardy–Weinberg equilibrium (P > 0.05). The analysis revealed that heterozygotes for the Gln27Glu polymorphic variant in the β2-АR gene were more frequent among BA patients vs. apparently healthy individuals (P = 0.018). The minor allele homozygotes (Glu/Glu) were 1.5 times more frequent among BA patients vs. the controls only in terms of trends without statistical significance. There was no statistically significant difference in the genotype distribution of the studied polymorphic variant between men and women in the control group and BA patient group (P = 0.55; P = 0.47). The analysis of BA risk showed a statistically significant association within the dominant (P = 0.01), super-dominant (P = 0.02), and additive (P = 0.01) models. The minor allele carriers Glu (predominantly heterozygotes) had 1.9 times higher risk of BA in the dominant model and 1.6 times higher risk of BA in the additive model vs. the major allele homozygotes. Conclusions. The statistically significant difference in the distribution of the homozygous and heterozygous genotypes of the β2-AR gene (Gln27Glu) polymorphism was found between asthma patients and apparently healthy individuals regardless of sex. The minor allele carriers (Gln/Glu genotypes) had the higher risk of BA vs. the major allele homozygotes.

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An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor (ADRB2) gene with risk of asthma in children

Abstract: None of the four polymorphisms in ADRB2 gene were associated with a risk of asthma in a current children population.

Cited by 7 publications

References 25 publications

Asthma susceptible genes in children

Asthma susceptible genes in children

The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature

GLN27GLU polymorphism in the β2-adrenergic receptor gene in patients with bronchial asthma

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