The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature

Abstract

Background The ADRB2 gene encodes the β2-adrenergic receptor (β2-AR). This study aimed to determine the association between the C79G polymorphism of the ADRB2 gene and its association with pediatric asthma using a meta-analysis of the published data. Material/Methods Review of publications up to May 2018 was from the PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and WanFang databases. The odds ratio (ORs) with 95% confidence interval (CI) were used in evaluating the strength of the reported association between the C79G polymorphism of the ADRB2 gene and pediatric asthma. Results There were 18 controlled studies that included 2,982 pediatric cases of asthma and 2,651 controls. Expression of the C79G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs . CC: OR, 0.69; 95% CI, 0.55–0.88) and the recessive model (GG vs . CC+CG: OR, 0.65; 95% CI, 0.53–0.81). Subgroup analysis by ethnicity showed a significantly reduced risk of pediatric asthma in Asian patients for comparison of the co-dominant model (GG vs . CC: OR, 0.59; 95% CI, 0.45–0.78), the recessive model (GG vs . CC+CG: OR, 0.58; 95% CI, 0.45–0.76), and the allelic model (G vs . C: OR, 0.89; 95% CI, 0.79–0.99). Conclusions The C79G polymorphism of the ADRB2 gene encoding β2-AR was associated with a reduced risk for the development of pediatric asthma, particularly in the Asian population.

GLN27GLU polymorphism in the β2-adrenergic receptor gene in patients with bronchial asthma

“…In contrast to previous findings, there are a number of studies that found no association between the studied polymorphism and the occurrence of asthma, disease severity, spirometric parameters, demographic and clinical variables, baseline respiratory function, number of exacerbations and hospitalizations, exercise tolerance, serum IgE, or the quality of patients' life [2,6,13]. Nevertheless, there was a study suggesting an association between polymorphic variants in the β 2 -AR gene and a lower BA risk in children and adults [4,14].…”

Age by Single Nucleotide Polymorphism Interactions on Bronchodilator Response in Asthmatics

“…These three SNPs were located on chromosomes 5 [near ADRB2 ], 10 [ CREM ], and 20 [ NCOA3 ]. ADRB2 [ 21 ] has previously been associated with asthma and NCOA3 is involved in transcriptional regulation and has previously been associated with BDR in Puerto Ricans with asthma [ 15 ]. While ADRB2 (the gene that encodes the direct target of SABAs) is one of the most widely studied candidate genes for BDR, its associations with this phenotype have been inconsistent [ 22 ], perhaps because studies thus far have not accounted for interactions between ADRB2 variants and age.…”

Asthma susceptible genes in children

“…[ 82 ] Our results and Guo et al [ 83 ] found -46 G/A and -79G/C polymorphisms of ADRB2 gene were not associated with a risk of childhood asthma. However, some studies [ 84 , 85 ] indicated that -79G/C polymorphism was associated with a reduced risk for the development of pediatric asthma. Some meta-analysis [ 86 , 87 ] found that CTLA-4 +49 A/G polymorphism might be a risk factor for asthma susceptibility, which contradicts our results.…”