An Assessment of Fertility in Boron-exposed Turkish Subpopulations

Sayli, B S; Tüccar, Ersöz; Elhan, Atilla Halil

doi:10.1016/s0890-6238(98)00013-6

Cited by 71 publications

(22 citation statements)

References 11 publications

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“…Although the mechanism is not yet clear, it is highly likely that maternal blood boron concentration is a good predictor of the concentration of boron at the target tissue (Murray and Schlekat, 2004). But later on, the studies showed that although the maternal blood boron concentration rises with the increased boron dose level given to rats, the similar result has not been achieved in pregnant and nonpregnant women objects Vaziri et al, 2001) These relations are the possible cause of the fact that some other researchers did not find any negative effects during studies on human reproductive toxicology (Saylı et al, 1998(Saylı et al, , 2001.…”

Section: Discussionmentioning

confidence: 99%

“…Determination of Boron in Drinking Water Supplies Saylı et al (1998) were the first to report data related to boron exposure in the study area. Boron concentrations were measured in drinking water from locations in regions I and II in the laboratories of the Balıkesir 25th Regional Directorate of State Hydraulic Works and the Bigadic Boron Works of the Eti Mine Works General Management.…”

Section: Boron Dose Determinationsmentioning

confidence: 99%

“…People in these villages have been employed in the mining of boron-containing minerals and in the cultivating of crops in these areas for more than a century. Saylı et al (1998) and Simsek et al (2003) indicate that the levels of boron and boron-containing minerals are unusually high in the tap water and the agricultural products grown in these areas. Women living in these villages therefore are exposed to boron through their diet; in addition, following sexual intercourse and during bathing, the genital and anal regions are washed directly with water, constituting another route of exposure to boron.…”

Section: Introductionmentioning

confidence: 99%

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Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Korkmaz

Uzgören

Bakırdere

et al. 2007

Environmental Toxicology

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Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boronrich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 6 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boronpoor areas ( 2 ¼ 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t ¼ À0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r ¼ 0.133, P ¼ 0.48, P > 0.05) and boron-poor (r ¼ À0.033, P ¼ 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 17-25, 2007.

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Section: Discussionmentioning

confidence: 99%

Section: Boron Dose Determinationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Korkmaz

Uzgören

Bakırdere

et al. 2007

Environmental Toxicology

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“…Two ecological studies recently assessed fertility and secondary sex ratios in relation to long-term exposure to boron among residents in two geographical regions in Turkey (Sayli et al 1998(Sayli et al , 2001. No detrimental effect was demonstrated on fertility, but an excess percentage of female births has been suggested.…”

Section: Introductionmentioning

confidence: 99%

Health Impact Evaluation of Boron in Drinking Water: A Geographical Risk Assessment in Northern France

Yazbeck

Kloppmann

Cottier

et al. 2005

Environ Geochem Health

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“…However, effects of boron on testicles, which are admitted as the most sensitive organ to boron, in terms of sperm parameters, semen freezability and fertilisation were not examined (19,20,26). Frequently, in different studies, effects of boric acid on the reproductive system of rats and mice have been tried to reveal based on dosage and time, high boric acid concentration intake results with antioxidant mechanism improvement (6,11).…”

Section: Introductionmentioning

confidence: 99%

Effects of boron added bull semen extender on post-thaw spermatological parameters

Tirpan¹,

Gürler²,

Olğaç³

et al. 2018

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:In this research, post-thaw effects of bull semen extenders including different amounts of boron (sodium pentaborate) on total motility (TMOT), progressive motility (PMOT), kinetic parameters of spermatozoa (VCL, VSL, VAP, LIN, STR, WOB, ALH, BCF), plasma membrane and acrosome integrity (PMAI) and DNA fragmentation index (DFI) were evaluated. Eight ejaculates were examined from four different bulls. Each ejaculate was split in to five aliquots and extended with standard Tris extender (Control) and 0.4 g boron with 0.5 g glucose (Group 1) 0.5; 0.7; 0.9 g boron without glucose (Group 2, Group 3 and Group 4 respectively) were used as experimental groups. After thawing TMOT, PMOT, kinetic traits of spermatozoa, PMAI and DFI were determined. According to motility and progressive motility (66.04%, 50.79%), Group 1 had higher values than the others, but differences between groups were not statistically significant (P>0.05). The highest values of VSL, LIN, STR and WOB were determined (28.15 µm/s, 42.98%, 71.69%, 59.71%) in Group 1 (P<0.05). While other kinetic traits of spermatozoa were higher numerically in Group 1 than the other groups, differences between groups were not statistically significant (P>0.05). The highest PMAI value was determined as 60.84% in Group 1 (P>0.05). The DFI rates were found similar in all control and experimental groups (P>0.05). In conclusion, it was observed that the boron (sodium pentaborate) has positive effects on post-thaw movement and structural traits. In addition, boron has no detrimental effect on DNA fragmentation index in semen freezing. Thus, boron could be used as an alternative semen extender compound.Keywords: Bull semen, CASA, flow-cytometry, frozen semen, sodium pentaborate. Boğa

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An Assessment of Fertility in Boron-exposed Turkish Subpopulations

Cited by 71 publications

References 11 publications

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Health Impact Evaluation of Boron in Drinking Water: A Geographical Risk Assessment in Northern France

Effects of boron added bull semen extender on post-thaw spermatological parameters

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