Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Korkmaz, Mehmet; Uzgören, Engin; Bakırdere, Sezgin; Aydın, Fırat; Ataman, O. Yavuz

doi:10.1002/tox.20229

Cited by 84 publications

(53 citation statements)

References 47 publications

(46 reference statements)

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“…Previous studies have shown that the fountain and tap water in this area contain 2 mg/l or higher levels of B 15,21 . The levels of B exposure of these subjects were compared with those of controls selected among the residents of Balıkesir and Ankara city centres.…”

Section: Geographic Locations and Samplingmentioning

confidence: 79%

“…The main sources of B are drinking water and consumption of locally grown agricultural products 15,21 . In fact, determination of B in agricultural products from this area gave relatively high concentrations 32 .…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence that B plays a role in healthy bones and joints 12,13 . Additionally, in recent years there have also been some promising results concerning the treatment of certain malignancies 14,15 .Toxicological effects have also been reported in animals at higher doses, e.g in mice, rats and rabbits skeletal malformations and cardiovascular defects have been observed 16,17 . Although not confirmed, it was claimed that B had a deleterious effect in humans, the target organ being the testis.…”

mentioning

confidence: 99%

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Estimation of human daily boron exposure in a boron-rich area

Korkmaz

Şaylı²,

Sayli

et al. 2007

Br J Nutr

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Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health. The aim of the present study was to estimate daily B exposure in 66 males in Turkey living in a B-rich area using water containing at least 2 mg/l boron, with an average age of 38·55 (SE 1·66) years and an average number of years of residence in the B-rich area of 35·89 (SE 1·73). Another group of males (n 57), living in the city centres of Balıkesir and Ankara, were taken as controls; the average age and number of years of residence for this group were 29·44 (SE 1·43) and 10·26 (SE 1·83) years, respectively. As it is assumed that the B level in urine reflects daily B exposure, the amount of urinary B of both the study and control groups was analysed by using an inductively coupled plasma optical emission spectrometry (ICP-OES) technique. The average daily B exposure value was calculated as 6·77 (SE 0·47) mg in the study group and 1·26 (SE 0·1) mg in the controls. The results of this study are expected to contribute to creating a reference value for a safe daily B exposure. Boron: Daily exposure: Risk assessmentRecent studies conducted both in vitro and epidemiologically have indicated that boron (B) exposure may make significant contributions to human health 1 -3 . Humans are naturally exposed to B via food and drinking water 4 . B is absorbed almost completely by the gastrointestinal and respiratory system if exposure occurs, and is mostly present in body tissues and fluids as boric acid, B(OH) 3 , and in lesser amounts as B(OH) 4 2 anion 5 . Studies indicate that B homeostasis is basically maintained by urinary excretion 6 .B was defined as a trace element in 1980 7 . In spite of the lack of epidemiological data, the WHO reported that boron may provide a physiological benefit for human health 8 . Safe and/or beneficial B levels have not been determined for humans, though animal studies have defined deleterious and beneficial B levels for animals 9 .In a study by Penland 10 , it was outlined that B improves brain function and psychomotor response. It increases steroid hormone concentrations and has antioxidant properties in postmenopausal women 9,11 . There is also evidence that B plays a role in healthy bones and joints 12,13 . Additionally, in recent years there have also been some promising results concerning the treatment of certain malignancies 14,15 .Toxicological effects have also been reported in animals at higher doses, e.g in mice, rats and rabbits skeletal malformations and cardiovascular defects have been observed 16,17 . Although not confirmed, it was claimed that B had a deleterious effect in humans, the target organ being the testis. Atrophy and eventual degeneration of the organ in several animal species at high doses have been shown 18,19 . Initially, reproduction toxicology studies were based upon data obtained from animal studies and adapted to human risk evaluations 20 . It was reported in several field studies that B does not affect human r...

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Section: Geographic Locations and Samplingmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Estimation of human daily boron exposure in a boron-rich area

Korkmaz

Şaylı²,

Sayli

et al. 2007

Br J Nutr

Self Cite

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“…In addition, it has been reported that boron compounds (such as borax, boric acid) are non-genotoxic agents on human blood cells (Turkez et al , 2010Geyikoglu and Turkez 2008;Turkez 2008). Furthermore, boron compounds have attracted much interest with respect to their protective effect against free radical damage that may be the cause of many diseases including cancer (Korkmaz et al 2007;Mahabir et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate

et al. 2015

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Boron compounds have an ability of supporting antioxidant properties in human and animal tissues. Lithium metaborate dihydrate (LiBO 2-2H 2 O; LMD) is commonly used in nonlinear optic materials, cellular phones and pagers. But, there are limited data on the genotoxic and antioxidant effects of LMD in cultured human whole blood cells. The aim of this study was to evaluate for the genotoxicity and antioxidant/oxidant activity of LMD on human whole blood lymphocytes (n = 5). LMD was applied at various concentrations (0-1,280 lg/ml) to cultured blood samples. Antioxidant/oxidant activity was evaluated by measuring the total oxidant status (TOS) and total antioxidant capacity levels. Micronuclei and chromosomal aberration tests were used in genotoxicity studies. Our results clearly revealed that all tested concentrations of LMD were found to be non-genotoxic when compared to that of the control group. In addition, LMD exhibited antioxidant activities at low concentrations. In addition the TOS levels were not changed at all concentrations of LMD. Consequently, our results clearly demonstrated that LMD is non-genotoxic and it has an important antioxidant potential in vitro.

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“…Çeşitli epidemiyolojik ve hücresel çalışmalarda borun bazı kanser türlerine karşı koruyucu özellikte olabileceği ileri sürülmüş özellikle prostat kanseri hücrelerinde bor uygulanmasıyla doz ve maruziyet süresine bağlı olarak bu hücre hatlarının proliferasyonunda düşüşler tespit edilmiştir [9,10]. Bor yönünden zengin bölgede yaşayan insanların bu kanser türleri açısından bor yönünden fakir bölgede yaşayan insanlardan daha az kanser insidansı taşıdığı saptanmıştır [7,11,12]. Korkmaz (2007) …”

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