An Assessment of Cochlear Hair-Cell Loss in Insulin-Dependent Diabetes Mellitus Diabetic and Noise-Exposed Rats

Raynor, Eileen M.; Carrasco, Vincent N.; Prazma, Jiri; Pillsbury, Harold C.

doi:10.1001/archotol.1995.01890040074012

Cited by 38 publications

(38 citation statements)

References 17 publications

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“…These changes strongly suggest that DM causes hearing loss. 27,[29][30][31][32] We found 18 cases (60 %) with altered vestibular tests. These findings are similar to published results 15,6,33,34 that have also shown altered vestibular tests.…”

Section: Discussionmentioning

confidence: 73%

“…They raised the hypothesis that the effect of DM on vestibular function might be caused by complications such as diabetic neuropathy and angiopathy, which are absent in initial phases of the disease. Various authors 27,[29][30][31] have previously suggested that microangiopathy might be responsible for DM-associated altered inner ear function.…”

Section: Discussionmentioning

confidence: 99%

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Manifestações vestibulococleares em pacientes com diabetes melito tipo I

Klagenberg

Zeigelboim

Jurkiewicz

et al. 2007

Rev. Bras. Otorrinolaringol.

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Gl ucose metabolism has a significant impact on inner ear physiology, and small changes may result in hearing and balance disorders. Aim: To investigate vestibulocochlear symptoms in patients with type I diabetes mellitus. Study design: a cross-sectional study of a contemporary group. Material and Method: 30 patients referred from Clinical Hospital-UFPR to the Laboratory of Otoneurology-UTP between Mar/2004 to Feb/2005 were evaluated. The following procedures were carried out: a medical history, otological inspections, audiometry, acoustic impedance tests, and vestibular function tests. Results: The prevalence of otoneurologic complaints was: headache (23.3%), vertigo (16.6%), and tinnitus (13.3%). The prevalence of associated complaints and habits was: caffeine abuse (20.0%), allergies (10.0%), and alcohol abuse (10.0%). The prevalence of normal auditory thresholds was 90.0%. Acoustic impedance showed no changes. The vestibular test showed changes in 60.0% of cases. Peripheral vestibular deficiency syndromes were also found. Conclusions: Significant vestibular system changes were found (60.0%) compared to the auditory system (10.0%). Audiometry revealed mostly normal results. The vestibular test showed changes in the peripheral vestibular system and the peripheral vestibular deficiency syndrome.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Manifestações vestibulococleares em pacientes com diabetes melito tipo I

Klagenberg

Zeigelboim

Jurkiewicz

et al. 2007

Rev. Bras. Otorrinolaringol.

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show abstract

“…Earlier literature on rats and diabetic patients showed hearing disorder mainly because of edema in stria vascularis, decrease in number of outer hair cells and spiral ganglion. [23][24][25] Increased thresholds at high frequencies revealed that the cochlear regions may have been damaged due to angiopathy in the stria vascularis and spiral ligament, edema of stria vascularis which in turn leads to reduced intensity and frequency coding. 16,26,27 A study on auditory brainstem response in individuals with diabetes revealed poor response with prolonged latencies of wave III, V and also prolonged latencies of inter-peak III-V, I-III and I-V at 90 dB presentation level 28 which showed that there is a participation of the relay station of different order neuron in the central auditory nervous system.…”

Section: Discussionmentioning

confidence: 99%

Temporal Modulation Transfer Function (TMTF) in Individuals With Diabetes Mellitus Type 2

Sanju¹,

Mishra²,

Kumar³

2016

Otolaryngol Open J

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Introduction: Diabetes mellitus is a collection of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action. Previous studies have shown the link between hearing impairment and diabetes. But, there is a lack of literature on patients with diabetes mellitus type 2 for auditory temporal resolution skills. Aim and Objective: The aim of the current research is to assess auditory temporal resolution skills using Temporal Modulation Transfer Function (TMTF) in persons with diabetes mellitus type 2 (elevated blood sugar level) having high frequency hearing loss. Methods: Fifteen individuals between the age of 30 to 40 years having diabetes mellitus type 2 with high frequency hearing loss recruited for the study as a clinical group. Fifteen age matched normal hearing subjects with no diabetes were taken as control group. To assess the temporal resolution ability, TMTF tests were administered. Research design used in this study was between group design. Result: The 2 groups were compared using independent t-test. It showed that in TMTF task the diabetic group with high frequency hearing loss (clinical) performed significantly poorer when compared to non-diabetic group having normal hearing (control). Overall Conclusion: It can be concluded that the reasons for having poorer performance in temporal resolution task in subjects with diabetes mellitus type 2 may be the changes in the central auditory nervous system and widening of auditory filter. The finding of the current study revealed that the processing at the level of central auditory system there is a deterioration due to impact of diabetes mellitus type 2.

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“…Moreover, animal studies from several decades ago have experimented the impact of diabetes in inner ear. Rats with alloxan-or streptozocininduced diabetes were observed and the results led to thickening of basal membrane of vascular striae and loss of outer hair cells (Maia and de Campos, 2005;Costa, 1967;Smith et al, 1995;Raynor et al, 1995). In their literature review, David et al (2015) argued that these abnormalities are likely due to disruption of blood supply to the cochlea, reduction of blood flow in affected vessels, or vestibulocochlear nerve degeneration.…”

Section: Microangiopathymentioning

confidence: 99%

Exploring the association between diabetes mellitus and hearing loss: Genetic mutation, neuropathy and microangiopathy

Akbar¹

2016

Sci. Res. Essays

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Diabetes mellitus (DM) has progressively increased in global prevalence. Recent studies have found that patients with DM may suffer from hearing impairment as a chronic complication. The effect of hearing loss may impair the quality of life of patients which affects functional, social, as well as psychological aspects. Both DM and hearing loss are considered to be associated, although this correlation remains elusive. There are three theories proposed to establish the association, which are microangiopathy, neuropathy and genetic mutation in mitochondrial DNA (mtDNA). This essay will initially discuss the importance of mtDNA mutations and neuropathy, as well as microangiopathy, in developing the expression of deafness in diabetes mellitus. It will also consider the limitation of these respective theories to explain the mechanism of hearing loss in diabetes mellitus patients.

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An Assessment of Cochlear Hair-Cell Loss in Insulin-Dependent Diabetes Mellitus Diabetic and Noise-Exposed Rats

Cited by 38 publications

References 17 publications

Manifestações vestibulococleares em pacientes com diabetes melito tipo I

Manifestações vestibulococleares em pacientes com diabetes melito tipo I

Temporal Modulation Transfer Function (TMTF) in Individuals With Diabetes Mellitus Type 2

Exploring the association between diabetes mellitus and hearing loss: Genetic mutation, neuropathy and microangiopathy

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