An antibacterial preparatum from hemp (Cannabis sativa L.)

Ferenczy, L.; Gracza, L.; Jakobey, I.

doi:10.1007/bf00621336

Cited by 13 publications

(9 citation statements)

References 1 publication

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“…Specifically, CBD has been shown to inhibit the growth in Gram-positive bacteria such as Streptomyces griseus and Staphylococcus aureus (Ferenczy et al 1958). These organisms are particularly sensitive to extracts of Cannabis in slightly acidic culture medium even at dilutions as low as 5 ppm.…”

Section: Cannabidiolmentioning

confidence: 99%

“…In previous experiments, CBD was found to inhibit the growth of Gram positive bacteria (Ferenczy et al, 1958). Previous reports of antibacterial activity with respect to CBD have primarily focused on CBD concentrates taken from the resin of the plant.…”

Section: Hemp Oil Bioassaymentioning

confidence: 99%

“…Therefore, it can be assumed that the concentration of CBD as a contaminant in the oil would be greater than the concentration of THC which has been reported in the literature. The presence of CBD is significant because it has documented anticonvulsive, anti-epileptic, and antimicrobial properties (Karler and Turkanis, 1973;Ferenczy, Gracza & Jakobey, 1958). Although the levels of CBD within the oil are typically small, many health benefits may still be gained from its presence.…”

Section: Introductionmentioning

confidence: 99%

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The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Leizer

Ribnicky

Poulev

et al. 2000

Journal of Nutraceuticals, Functional & Medical Foods

239

150

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ABSTRACT. The fatty acid and natural product content of hemp seed oil was analyzed by GC-MS and LC-MS. The presence of linoleic acid (LA) and a-linolenic acid (LNA) were confirmed in their previously reported ratio of 3:1 LA:LNA. The presence of b-caryophyllene (740 mg/L), myrcene (160 mg/L), b-sitosterol (100-148 g/L) and trace amounts of methyl salicylate was observed in the oil which had not been previously reported. Trace amounts of cannabidiol (CBD) were also detected. Bioassays were performed with the oil to determine its effectiveness as an antimicrobial agent. Some bioactivity was observed during the primary screening.

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Section: Cannabidiolmentioning

confidence: 99%

Section: Hemp Oil Bioassaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Leizer

Ribnicky

Poulev

et al. 2000

Journal of Nutraceuticals, Functional & Medical Foods

239

150

View full text Add to dashboard Cite

show abstract

“…Furthermore, he prepared a salve containing 2% extracts and demonstrated its therapeutic efficacy in the treatment of skin infections with Staphylococci [101]. Independently, Drobotko et al described the occurrence of antibacterial activity in extracts from hemp in 1951 [102], while Ferenczy et al reported the finding of the occurrence of antibacterial activity in extracts obtained from seeds of hemp in 1956 [103,104]. Ferenczy et al demonstrated the potency of the antimicrobial activity using dilutions of their extracts and observed that their activity was pH-dependent [104].…”

Section: Antimicrobial Activities Of Phytocannabinoids From Cannabis mentioning

confidence: 99%

Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits?

Klahn

2020

Antibiotics

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Novel antimicrobial drugs are urgently needed to counteract the increasing occurrence of bacterial resistance. Extracts of Cannabis sativa have been used for the treatment of several diseases since ancient times. However, its phytocannabinoid constituents are predominantly associated with psychotropic effects and medical applications far beyond the treatment of infections. It has been demonstrated that several cannabinoids show potent antimicrobial activity against primarily Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). As first in vivo efficacy has been demonstrated recently, it is time to discuss whether cannabinoids are promising antimicrobial drug candidates or overhyped intoxicants with benefits.

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“…More than 100 different chemical compounds called cannabinoids can be extracted from hemp as reported by García-Tejero et al [12]. Many studies suggest that cannabidiol (CBD) has potential antimicrobial effects, especially against drug-resistant strains of Staphylococcus aureus [13][14][15]. Although HSO does not traditionally contain cannabinoids as it is found on the plant's leaves and flowers, an alternative hemp oil called Hemp Essential Oil (HEO) could be used to utilize a variety of the plant's beneficial components.…”

Section: Introductionmentioning

confidence: 99%

Hemp Growth Factors and Extraction Methods Effect on Antimicrobial Activity of Hemp Seed Oil: A Systematic Review

Ostapczuk

Apori

Estrada³

et al. 2021

Separations

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The bioactive Hemp Seed Oil (HSO) is becoming very popular in the medical and research fields due to its antimicrobial properties against several diseases caused by bacteria and fungi. However, the effect of hemp-growing factors and extraction methods on the bioactivity of HSO does not receive adequate research attention. Therefore, this review aims to investigate the effect of growth factors and extraction methods on the antimicrobial activity of HSO. Articles were retrieved from Google Scholar and the Scopus database and screened against inclusion and exclusion criteria. The study revealed that HSO prefers warm climates and favorable humidity ranging from 20 to 39 °C and 79–100% per year, respectively, and rainfall of 324 mm daily. The multivariate linear regression shown excellent prediction (R2 = 0.94) with climates upon Zone of Growth Inhibition (ZGI) of Gram-positive bacteria. Temperature is the strongest predictor (p < 0.01) followed by humidity and rainfall (p < 0.05). Furthermore, well-drained loam soil rich in organic matter seems to stimulate the antimicrobial activity of HSO. The major constituents that influence HSO’s antimicrobial ability to Staphylococcus aureus were cannabidiol (CBD), β-caryophyllene, and limonene. The extraction methods showed less influence on the HSO bioactivity. HSO did not show significant antioxidant activity, but Hemp Seed Hull (HSH), Hemp Seed Flour (HSF), and Hydrolyzed Hemp Seed Protein (HPH), expressed promising DPPH scavenging ability.

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An antibacterial preparatum from hemp (Cannabis sativa L.)

Cited by 13 publications

References 1 publication

The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits?

Hemp Growth Factors and Extraction Methods Effect on Antimicrobial Activity of Hemp Seed Oil: A Systematic Review

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