Hemp Growth Factors and Extraction Methods Effect on Antimicrobial Activity of Hemp Seed Oil: A Systematic Review

Ostapczuk, Klaudia; Apori, Samuel Obeng; Estrada, Giovani; Tian, Furong

doi:10.3390/separations8100183

Cited by 13 publications

(11 citation statements)

References 59 publications

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“…The significant alteration in ruminal microbiota community structure, diversity and composition observed in hemp heifers may be attributed to several antimicrobial components contained within the hempseed cake. The oil content (7%) may have influenced the ruminal microbial composition as the antibacterial activity of hempseed oil against a wide range of Gram-positive bacterial species has been well documented 18 , 44 , 45 . In addition, the psychoactive components and cannabinoid derivatives in hempseed cake, have known antimicrobial activity against a large panel of Gram-positive and Gram-negative pathogens 46 , and may have similar activity in the rumen.…”

Section: Discussionmentioning

confidence: 99%

Feeding hempseed cake alters the bovine gut, respiratory and reproductive microbiota

Winders

Holman

Schmidt

et al. 2023

Sci Rep

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A growing number of studies have investigated the feasibility of utilizing hemp by-products as livestock feedstuffs; however, their impact on livestock microbiomes remains unexplored. Here, we evaluated the effects of feeding hempseed cake on the gastrointestinal, respiratory, and reproductive microbiota in beef heifers. Angus-crossbred heifers (19-months old, initial body weight = 494 ± 10 kg [SE]) were fed a corn-based finishing diet containing 20% hempseed cake as a substitute for 20% corn dried distillers’ grains with solubles (DM basis; Control; n = 16/group) for 111 days until slaughter. Ruminal fluid and deep nasopharyngeal swabs (days 0, 7, 42, 70 and 98), and vaginal and uterine swabs (at slaughter) were collected, and the microbiota assessed using 16S rRNA gene sequencing. Diet affected the community structure of the ruminal (d 7−98; 0.06 ≤ R2 ≤ 0.12; P < 0.05), nasopharyngeal (d 98; R2 = 0.18; P < 0.001), and vaginal (R2 = 0.06; P < 0.01) microbiota. Heifers fed hempseed cake had increased microbial diversity in the rumen, reduced microbial richness in the vagina, and greater microbial diversity and richness in the uterus. In addition to the distinct microbial communities in the rumen, nasopharynx, vagina and uterus, we identified 28 core taxa that were shared (≥ 60% of all samples) across these sampling locations. Feeding hempseed cake appeared to alter the bovine gut, respiratory and reproductive microbiota. Our results suggest that future research aiming to evaluate the use of hemp by-products in livestock diet should consider their impact on animal microbiome and microbiome mediated animal health and reproductive efficiency. Our findings also highlight the need for research evaluating the impact of hemp-associated food and personal care products on the human microbiome.

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Section: Discussionmentioning

confidence: 99%

Feeding hempseed cake alters the bovine gut, respiratory and reproductive microbiota

Winders

Holman

Schmidt

et al. 2023

Sci Rep

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“…In fact, the ability of the compound to destroy cell membranes and the low concentration of LPS might make G‐ve bacteria more susceptible to the effects of CBD. In the bibliographic research, the antimicrobial activity against Staphylococcus aureus may be linked to some single constituents such as CBD [26] …”

Section: Resultsmentioning

confidence: 99%

“…In the bibliographic research, the antimicrobial activity against Staphylococcus aureus may be linked to some single constituents such as CBD. [26] Antifungal Activity…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

Exploring the Diverse Biological Properties of Cannabidiol: A Focus on Plant Growth Stimulation

Gruľová,

Baranová,

Francolino

et al. 2024

Chemistry & Biodiversity

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The aim of the current study was to compare some biological activities of edible oils enriched with 10% of cannabidiol (CBD samples) from the Slovak market. In addition, hemp, coconut, argan, and pumpkin pure oils were also examined. The study evaluated the fatty acids content, as well as antibacterial, antifungal, antioxidant, cytotoxic, and phytotoxic activities. The CBD samples presented antimicrobial activity against the tested bacterial strains at higher concentrations (10000 and 5000 mg/L) and antifungal activity against Alternaria alternata, Penicillium italicum and Aspergillus flavus. DPPH• and FRAP assays showed greater activity in CBD‐supplemented samples compared to pure oils and vitamin E. In cell lines (IPEC‐J2 and Caco‐2), a reduced cell proliferation and viability were observed after 24 hours of incubation with CBD samples. The oils showed pro‐germinative effects. The tested activities were linked to the presence of CBD in the oils.

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“…The signi cant alteration in ruminal microbiota community structure, diversity and composition observed in hemp heifers may be attributed to several antimicrobial components contained within the hempseed cake. The oil content (7%) may have in uenced the ruminal microbial composition as the antibacterial activity of hempseed oil against a wide range of Gram-positive bacterial species has been well documented (Mikulcová et al, 2017;Agrawal et al, 2021;Ostapczuk et al, 2021). In addition, the psychoactive components and cannabinoid derivatives in hempseed cake , have known antimicrobial activity against a large panel of Gram-positive and Gram-negative pathogens (Karas et al, 2020), and may have similar activity in the rumen.…”

Section: Discussionmentioning

confidence: 99%

346 Feeding Hempseed Cake Alters the Bovine gut, Respiratory and Reproductive Microbiota

Winders

Holman

Schmidt

et al. 2022

Journal of Animal Science

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A growing number of studies have investigated the viability of feeding hemp by-products as livestock feedstuffs; however, their impact on livestock microbiomes remains unexplored. Here, we evaluated the effects of feeding hempseed cake (HSC) on the gastrointestinal, respiratory, and reproductive microbiota in beef heifers. Angus-crossbred heifers [19-months old; initial body weight (BW) = 494 ± 10 kg] were fed a corn-based finishing diet (10% forage) containing either 20% HSC (n = 15) or 20% corn distillers grains (Control, n = 16) for 111 days until slaughter. Individual feed intake, feeding behavior and BW were measured throughout the study. Rumen fluid and deep nasopharyngeal swabs (days 0 7, 42, 70 and 98), and vaginal and uterine swabs (at slaughter) were collected, and the microbiota assessed using 16S rRNA gene sequencing. HSC feeding resulted in reduced average daily gain (P = 0.05) without influencing feed intake and feeding behavior (P > 0.05) (reported elsewhere). Sampling time had a significant effect on both ruminal (PERMANOVA: R2 = 0.39; P < 0.001) and nasopharyngeal (R2 = 0.18; P < 0.001) microbial community structure. There was also a significant effect of diet on the ruminal (d7– 98; 0.06 ≤ R2 ≤ 0.12; P < 0.05), nasopharyngeal (d 42; R2= 0.18; P < 0.001), and vaginal (R2 = 0.06; P < 0.01) microbiota. Although microbial richness in the rumen, nasopharynx, vagina, and uterus was not affected (P > 0.05) by HSC feeding, microbial diversity (Shannon diversity) was increased in the rumen (d42-98) but reduced in the uterus of HSC heifers (P < 0.05). The relative abundance of five ruminal genera was enriched, while five vaginal genera were reduced in HSC heifers (P < 0.05). Overall, the results of our longitudinal study suggest that feeding hemp by-products can alter the bovine gut, respiratory and reproductive microbiota.

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Hemp Growth Factors and Extraction Methods Effect on Antimicrobial Activity of Hemp Seed Oil: A Systematic Review

Cited by 13 publications

References 59 publications

Feeding hempseed cake alters the bovine gut, respiratory and reproductive microbiota

Feeding hempseed cake alters the bovine gut, respiratory and reproductive microbiota

Exploring the Diverse Biological Properties of Cannabidiol: A Focus on Plant Growth Stimulation

346 Feeding Hempseed Cake Alters the Bovine gut, Respiratory and Reproductive Microbiota

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