An Antibacterial Biphenyl Derivative from Garcinia bancana MIQ.

Rukachaisirikul, Vatcharin; Naklue, Wanpen; Sukpondma, Yaowapa; Phongpaichit, Souwalak

doi:10.1248/cpb.53.342

Cited by 47 publications

(25 citation statements)

References 9 publications

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“…Compound 4 is already known to fight methicillin-resistant S. aureus and might be an alternative for classical antibiotic treatments (Iinuma et al, 1996). The MIC value of 16 mg/mL for S. aureus was identical to the value previously obtained with compound 4 purified from Garcinia bancana (Rukachaisirikul et al, 2005). Compound 5 exhibited a strong antibacterial activity with a MIC of 2 mg/mL against both S. aureus and E. faecalis.…”

Section: Discussionsupporting

confidence: 72%

Isolation and biological activity of compounds fromGarcinia preussii

Messi

Lannang

et al. 2014

Pharmaceutical Biology

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Context: Plants of the genus Garcinia (Clusiaceae) are traditionally used to relieve stomachaches, toothaches, and as a chew stick. Objective: In order to determine which compounds were responsible for these activities, a phytochemical investigation of the fruits and leaves of Garcinia preussii Engl. was pursued. Materials and methods: Plants were extracted by solvents of various polarities. Compounds isolation was then carried out using chromatography methods (medium-and high-pressure liquid chromatography, open column and thin-layer chromatography). The isolated compounds were identified and characterized by using 1D and 2D NMR spectroscopies. The antioxidant activity was evaluated using DPPH , ABTS À , ALP, and ORAC assays. The antimicrobial activity was assayed against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis by determining the minimum inhibitory concentration (MIC) value. The cytotoxic activity of most of the isolated compounds was evaluated on a small panel of human cancer cell lines (DU145, HeLa, HT-29, and A431) using the XTT method. Results: The phytochemical investigation of G. preussii led to the isolation of eight known compounds, six benzophenones and two flavonoids. These compounds were tested for their biological activities. 1, 2, 3, 4, 7 and 8 demonstrated a high free radical scavenging activity with ER 50 ranging from 0.1 to 0.7. The antimicrobial activity was shown only against Gram-positive bacteria for 1, 4, and 5. A moderate cytotoxic activity with IC 50 ranging from 7 to 50 mM was observed, except for 6 which was not active. Conclusion: These results appear to support some of the properties reported for Garcinia species.

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Section: Discussionsupporting

confidence: 72%

Isolation and biological activity of compounds fromGarcinia preussii

Messi

Lannang

et al. 2014

Pharmaceutical Biology

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“…It possesses a strong growth-inhibitory effect against human leukemia HL-60 cells (Pan et al , 2001). Garcinol also shows antibacterial activity against Methicillin-resistant Staphylococcus aureus, comparable with that of the antibiotic Vancomycin (Rukachaisirikul et al , 2005; Iinuma et al , 1996). It is a natural histone acetylase transferase inhibitor both in vitro and in vivo , suggesting its implication in a wide variety of diseases like cancer and AIDS (Balasubramanyam et al , 2004; Mantelingu et al , 2007).…”

Section: Introductionmentioning

confidence: 97%

Antioxidant and hepatoprotective effect of Garcinia indica fruit rind in ethanolinduced hepatic damage in rodents

Panda¹,

Ashar²,

Srinath³

2012

Interdisciplinary Toxicology

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The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) on ethanol-induced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. Liver damage was induced in rats by administering ethanol (5 g/kg, 20% w/v p.o.) once daily for 21 days. GIE at 400 mg/kg and 800 mg/kg and the reference drug silymarin (200 mg/kg) were administered orally for 28 days to ethanol treated rats, this treatment beginning 7 days prior to the commencement of ethanol administration. Levels of marker enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP)), triglyceride (sTG), albumin (Alb) and total protein (TP) were evaluated in serum. Antioxidant parameters (reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR)), hepatic triglycerides (hTG) and the lipid peroxidation marker malondialdehyde (MDA) were determined in liver. GIE and silymarin elicited significant hepatoprotective activity by attenuating the ethanol–elevated levels of AST, ALT, ALP, sTG, hTG and MDA and restored the ethanol-depleted levels of GSH, SOD, CAT, GPx, GR, Alb and TP. GIE 800 mg/kg demonstrated greater hepatoprotection than GIE 400 mg/kg. The present findings indicate that hepatoprotective effects of GIE in ethanol-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation in liver.

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“…In the present study, the group A extracts (Table 4), especially those exhibiting high selectivity indices for inhibition of NO, such as G. bancana (stem) and G. malaccensis (stem) are expected to contain potent lead anti-inflammatory agents which could pave the way in the discovery of novel clinical candidates. A recent study reported the isolation of garcinol, isogarcinol and [1,1'-biphenyl]-2-(3-methyl-2-butenyl)-3-methoxy-4,4' ,5,6-tetraol as antibacterial agents from G. bancana twigs (Rukachaisirikul et al, 2005) and since the plant showed NO inhibitory activity, we propose these compounds could also potentially be responsible for NO inhibition. Nevertheless, other extracts in this group should also be studied further for isolation of their phytochemicals responsible for the NO inhibitory activity.…”

Section: Discussionmentioning

confidence: 87%

“…The biological activities of the isolated compounds include anti-inflammatory (Nakatani et al, 2002), anti-HIV (Lin et al, 1997) and antibacterial (Permana et al, 2001;Rukachaisirikul et al, 2003Rukachaisirikul et al, , 2005. Xanthones are especially noted as potential anticancer agents (Thoison et al, 2000;Matsumoto et al, 2003a;Chiang et al, 2003;Ito et al, 2003a).…”

Section: Introductionmentioning

confidence: 99%