An Analysis of Hypoplastic Anæmia With Special Reference to the Use of Oxymetholone (”adroyd“) in Its Therapy

Silink, Sandra J.; Firkin, Barry G.

doi:10.1111/imj.1968.17.3.224

Cited by 23 publications

(11 citation statements)

References 28 publications

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“…Sanchez-Medal et al (1969) claimed a remission rate of 70% in patients with aplastic anaemia who lived longer than 2 months and thus received an adequate trial with oxymetholone. Similar results have been reported by Allen et al (1968) and by Silink and Firkin (1968).…”

Section: Discussionsupporting

confidence: 92%

Oxymetholone in aplastic anaemia

Delamore

1974

Postgraduate Medical Journal

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Summary Thirty-one patients with aplastic anaemia were treated with oxymetholone. Twenty-eight patients lived beyond 2 months and of these eleven patients showed clinical and haematological improvement. Ten of these had some active erythropoietic areas as shown by bone marrow biopsies and by the presence of an elevated reticulocyte count in the peripheral blood. Two patients who responded in spite of a markedly hypoplastic marrow and reticulocytopenia became oxymetholone dependent and relapsed when the drug was withdrawn. They failed to respond a second time when oxymetholone was re-introduced. Side effects were frequent. These were mostly tolerable and reversible on reduction of the dose but three patients died of acute myeloblastic leukaemia and in three others the drug had to be withdrawn.

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Section: Discussionsupporting

confidence: 92%

Oxymetholone in aplastic anaemia

Delamore

1974

Postgraduate Medical Journal

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“…In 1964, Sanchez-Medal et al [11] reported remission in 70% of cases of various types of chronic refractory anaemia after treatment with a new anabolic steroid, oxymetholone. Several more recent reports [2,7,12,15] have, in part, supported these findings.The aim of this study was to determine the type of hypoproliferative anaemia that best responds to a standard, high-dose oxymetholone re-1 Studies on aregenerative anaemia, III. …”

mentioning

confidence: 55%

“…Sanchez-Medal et al [11,12] reported a remission rate of 70°/o after 2 months treatment. Silink and F irkin [15] showed improvement in 8 of 11 pa tients (one of whom had myelofibrosis) after from 5 to 12 weeks of thera py. Allen et al [2] reported 100°/o improvement in 5 children who had failed to respond to testosterone.…”

Section: Discussionmentioning

confidence: 97%

Oxymetholone Treatment in Hypoproliferative Anaemia<sup>1</sup>

et al. 1973

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45 patients with hypoproliferative or aregenerative anaemia were treated with oxymetholone, steroid an anabolic, androgenic steroid. Minimum treatment time accepted for entrance into the study was 3 months. Therapeutic effect was assessed by effect on bone marrow cellularity, haemoglobin concentration and granulocyte and platelet counts. Patients with a hypocellular marrow responded best. Of 18 cases, a partial remission was seen in 8 and a complete remission in 5. A complete remission was only seen in patients who did not have pancytopenia. Of the 7 patients with myelofibrosis, 4 had thrombocytopenia at the outset. Improvement after treatment was seen in all 4. The only serious side-effect that necessitated withdrawal of treatment was jaundice.

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“…The failure of conventional therapy with high dosage corticosteroids and repeated whole blood, packed cell, and platelet transfusions prompted attempts at marrow stimulation with phytohaemagglutinin (PHA) (Baker & Oliver, 1965;Catovsky & Sforza, 1967;Grunewald et al, 1965;Hayes & Spurr, 1966;Retief, Wasserman & Hofmeyer, 1964) and oxymetholone (Sanchez-Medal, G6mez-Leal & Duarte-Zapata, 1966;Sanchez-Medal et al, 1964;Silink & Firkin, 1968;Allen et al, 1968). These were tried in turn, corticosteroids being continued throughout to reduce the bleeding tendency.…”

Section: Discussionmentioning

confidence: 99%