An allied approach for in vitro modulation of aldose reductase, sorbitol accumulation and advanced glycation end products by flavonoid rich extract of Coriandrum sativum L. seeds

Kajal, Anu; Singh, Randhir

doi:10.1016/j.toxrep.2018.08.001

Cited by 11 publications

(9 citation statements)

References 25 publications

(41 reference statements)

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“…A previous study showed that the binding of ligand and RAGE, such as flavonoids–RAGE, to block AGEs–RAGE combination is an effective approach for alleviating AGEs-induced oxidative damage and inflammation [ 35 , 36 ]. Kajal et al reported that the extract of Coreandrum sativum L. seeds, which is rich in flavonoids, can form hydrogen bonds and establish hydrophobic interactions with RAGE residues to inhibit diabetic complications [ 37 ]. Molecular docking results in the present work may further explain to a certain extent the mechanisms and differences among the three dietary flavonoids in inhibiting AGEs-induced inflammation from another perspective.…”

Section: Resultsmentioning

confidence: 99%

Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro

Jia

Sun

et al. 2022

Nutrients

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The aim of this study was to compare the protective effects of three dietary flavonoids (apigenin-7-O-glucoside (A7G), isorhamnetin-3-O-rutinoside (I3R), and cyanidin-3-O-glucoside (C3G)) on advanced glycation end products (AGEs)-induced inflammation and vascular endothelial dysfunction. Furthermore, the potential mechanisms of varied effects of those three dietary flavonoids were analyzed by molecular docking analysis. Results showed that C3G (40 μM) achieved the best inhibition on inflammatory cytokines (TNF-α, IL-1β, and IL-6) in AGEs-induced RAW264.7 cells, followed by I3R, and A7G was the weakest. The molecular docking results also showed that C3G exhibited the closest binding with the receptor for AGE. However, I3R (40 μM) demonstrated the best effect in improving endothelial dysfunction in AGEs-induced EA.hy926 cells, followed by C3G, and A7G was the weakest, as evidenced by the molecular docking results of flavonoids with profilin-1. This work may provide knowledge and helpful suggestions regarding the benefits of dietary flavonoids in diabetic vascular complications.

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Section: Resultsmentioning

confidence: 99%

Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro

Jia

Sun

et al. 2022

Nutrients

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“…Sorbitol availability to tissues containing SDH depends on the concentration of glucose in serum, which varies with the severity of diabetes [17, 21]. Due to its stable and chemically unreactive behavior, it would be advantageous to study the pharmacokinetics of sorbitol in serum.…”

Section: Resultsmentioning

confidence: 99%

“…This work focuses on the potential mechanism that deals with the determination of sorbitol in serum medium by an enzymatic spectrophotometric method, and furthermore its clear beneficial interaction with caffeine for screening and plausible remediation of DN [20,21,59]. Based on the results of our experiment, a strategy was established wherein caffeine has a synergistic interaction with sorbitol.…”

Section: Discussionmentioning

confidence: 99%

“…Enzymatic or chromatographic (highperformance liquid chromatography, electromagnetic sensing, gas chromatography-mass spectrometry, Fourier transform infrared, capillary electrophoresis, ion chromatography, etc.) methods are typically exercised to diagnose sorbitol levels in different analytes [20][21][22][23][24]. The fluorometric enzymatic assay is a simple, convenient, and most frequently used method for the evaluation of sorbitol level in the diabetic state [25].…”

Section: Introductionmentioning

confidence: 99%

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Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy

Srivastava

Sen

2020

Biotech and App Biochem

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The measure of sorbitol in serum can act as a good indicator in the monitoring of the diabetic complications. To analyze the sorbitol level in serum medium, fluorometric enzymatic assay was performed. To remove the excess sorbitol from the body, proposed binding of sorbitol with caffeine was investigated. Their interaction in serum medium was studied and established by UV-Vis, fluorescence spectrophotometry, and time-correlated single photon counting (TCSPC). The linear calibration of sorbitol (in the range 10-50 mM) was done using UV-Vis spectrophotometry. Time scan experiments furnished the reaction rate of sorbitol assayed solution as well as sorbitol-caffeine complex as 0.021 min −1 and 0.018 min −1 , respectively. A sudden drop was observed in the fluorescence lifetime of reduced nicotinamide adenine dinucleotide (NADH) present in sorbitol assayed solution upon complexation with caffeine, that is, from 1.774 × 10 −09 to 1.23 × 10 −10 Sec, which indicates the hindrance in the formation of NADH and the probable formation of some other species. Isothermal titration calorimetric experiments clearly indicate the number of binding sites (i.e., 3.89, 1.40, and 2.07) that exist between sorbitol and caffeine at the complexation ratio of 1:1.2, 1:1.5, and 1:3. The present method can be helpful in pharmacological and therapeutic studies of sorbitol using caffeine for treating diabetic neuropathy.

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“…The popularity of conventional herbal medicines is increasing each year [18]. Coriander has antioxidant, anticancer, hypolipidemic, neuroprotective, anticonvulsant, analgesic, migraine-relieving, hypoglycemic, hypotensive, anxiolytic, antimicrobial, and antiinflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Influence of Organic and Inorganic Fertilizers on Coriander (Coriandrum sativum L.) Agronomic Traits, Essential Oil and Components under Semi-Arid Climate

Özyazıcı

2021

Agronomy

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Environmental contamination and the excessive use of inorganic fertilizers resulting in stagnant yields of field crops which necessitate the utilization of combined fertilization approach under changing climatic conditions. Current study was aimed to clarify the influence of several fertilizer sources (chemical, organic, organomineral fertilizers) on yield and quality of coriander (Coriandrum sativum L.). The results revealed that the fertilizer sources significantly affected the yield of coriander cultivars. The absence of “Year x Variety x Fertilizer Type” interactions for any of the noted parameters signaled that the detected “Variety x Fertilizer Type” interactions were constant regardless of the year factor. The recorded values of traits according to fertilizer sources different for the plant height from 61.85 to 69.67 cm, number of branches from 5.98 to 7.71 (piece/plant), number of umbels per the main umbel from 5.62 to 7.18 pieces, seed yield from 1.06 to 1.66 t/ha, the biological yield from 4.29 to 5.70 t ha−1, harvest index from 25.29 to 29.41%, essential oil ratio from 0.29 to 0.33%, and essential oil yield from 3.1 to 5.6 L ha−1. Erbaa variety was observed to be superior over the rest of the varieties producing the maximum values of 6.5 L ha−1 of essential oil, 0.36% essential oil content, 30.9% harvest index, 1.81 t/ha seed yield, and 5.9 t ha−1 biological yield with the treatment of chemical fertilizers.

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An allied approach for in vitro modulation of aldose reductase, sorbitol accumulation and advanced glycation end products by flavonoid rich extract of Coriandrum sativum L. seeds

Abstract: Graphical abstract

Cited by 11 publications

References 25 publications

Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro

Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro

Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy

Influence of Organic and Inorganic Fertilizers on Coriander (Coriandrum sativum L.) Agronomic Traits, Essential Oil and Components under Semi-Arid Climate

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