An Alberta Cree Indian with a Rare Duffy Antibody, Anti‐Fy 3

Buchanan, Donald I.; Sinclair, Margaret; Sanger, Ruth; Gavin, June; Teesdale, Phyllis

doi:10.1111/j.1423-0410.1976.tb02801.x

Cited by 25 publications

(9 citation statements)

References 6 publications

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“…It was concluded that this frequency varied depending on the anti‐Fy b reagent used, but weak expression of Fy b could be demonstrated in all of these cases. The existence among Caucasians of an allele, Fy x , correlating with weak Fy b expression on RBC was proposed more than three decades ago ( Chown et al , 1965 ) and later investigated at the serological level by others ( Cedergren & Giles, 1973; Buchanan et al , 1976 ; Habibi et al , 1980 ). From these and other studies it has been shown that the antigens Fy3 and Fy5 were also depressed ( Daniels, 1995).…”

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confidence: 99%

The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein

et al. 1998

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Screening by allele-specific primer PCR (ASP-PCR) for these mutations among 100 Caucasian and 100 Black random blood donors indicated allele frequencies of 2 . 5% and 0%, respectively. Ala100Thr alone was present in 33% of the Caucasians (but none of the Blacks) with no weakening of FY expression.A novel allele at the FY locus associated with the Fy x phenotype was studied. Mistyping of this weak Fy b antigen in clinical transfusion medicine may lead to delayed haemolytic transfusion reactions in immunized patients. A potential role for genomic typing is proposed.

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confidence: 99%

The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein

et al. 1998

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“…The serological characteristics of the Fy(aÀ bÀ) phenotype of a Cree Indian woman (patient 1), who lives in a remote area of Northern Alberta, were reported previously (Buchanan et al, 1976). This patient's serum was found to contain a strongly reactive anti-Fy3 during her eighth pregnancy.…”

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confidence: 66%

New genotypes in Fy(a− b−) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B

et al. 2000

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Duffy blood group antigens are carried on a glycoprotein that is predicted to pass through the erythrocyte membrane seven times and is a promiscuous chemokine receptor. The Fy(a- b-) phenotype is present in two-thirds of African-American Blacks but is rare in Caucasians. In Blacks, the phenotype is due to a non-functional GATA-1 motif in the FY B, which silences the gene in erythrocytes but not in other tissues, and these patients do not generally make anti-Fyb or anti-Fy3. We describe here the molecular analysis of FY in three unrelated Caucasians who were studied because they had strong anti-Fy3 in their serum. Each was found to have a point mutation that was predicted to change a tryptophan to a premature stop codon in the coding sequence. In one patient (patient 1), the nonsense mutation was at nucleotide 287 of the major transcript in FY A; in another (patient 2), it was at nucleotide 407 in the major transcript of FY B; and in a third (patient 3), it was at nucleotide 408 of the major transcript of FY A.

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“…Investigation of her serum during prenatal testing of her third pregnancy led to the discovery of the antibody, and she was phenotyped as Fy(a-b-). 15 Subsequent reports have described the same antibody in a Cree Indian woman and in other Caucasian patients, [16][17][18] all of them with a history of transfusion or pregnancy. Interestingly, African American individuals whose RBCs phenotype as Fy(a-b-) usually develop anti-Fy3 after making anti-Fy a or other alloantibodies.…”

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confidence: 91%

Acute hemolytic transfusion reaction secondary to anti-Fy3

et al. 2005

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A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hb 7g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with an LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. Immunohematology 2005;21:48-52.

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An Alberta Cree Indian with a Rare Duffy Antibody, Anti‐Fy 3

Cited by 25 publications

References 6 publications

The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein

The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein

New genotypes in Fy(a− b−) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B

Acute hemolytic transfusion reaction secondary to anti-Fy3

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An Alberta Cree Indian with a Rare Duffy Antibody, Anti‐Fy 3

Cited by 25 publications

References 6 publications

The Fyx phenotype is associated with a missense mutation in the Fyb allele predicting Arg89Cys in the Duffy glycoprotein

The Fyx phenotype is associated with a missense mutation in the Fyb allele predicting Arg89Cys in the Duffy glycoprotein

New genotypes in Fy(a− b−) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B

Acute hemolytic transfusion reaction secondary to anti-Fy3

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The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein

The Fy^x phenotype is associated with a missense mutation in the Fy^b allele predicting Arg89Cys in the Duffy glycoprotein