An Action of Mogadon on the Amygdala of the Cat

Schallek, William; Kuehn, Alfred

doi:10.1159/000135549

Cited by 9 publications

(3 citation statements)

References 3 publications

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“…It enhances both the respiratory depressant and hypotensive effects of halothane. It Pharmacology Diazepam (7-chloro-1,3-dihydro-1-methyl-5phenyl-2H-1,4-benzodiazepin-2-one) is an anticonvulsant and tranquillizer, the latter feature being attributed to depression of the limbic system whilst the brain-stem reticular structures are relatively unaffected (Schallek & Kuehn 1965). Polysynaptic spinal reflexes are depressed and abnormalities in the electroencephalogram are reduced.…”

Section: Pentazocine Occasionally Causes Hypertensionmentioning

confidence: 99%

Analgesic Drugs [Abridged]

Hollis

1969

Proceedings of the Royal Society of Medicine

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20pressures unless halothane was administered: 0 5% halothane could cause a rapid rise of central venous pressure by 8 cmH2O and fall of arterial pressure by 10-15 mmHg.Eighty patients undergoing major intracranial and spinal operations were studied. In 50 patients, intra-arterial and central venous pressures, electrocardiograms and pulse rate were recorded. Intermittent positive pressure ventilation was used throughout, maintaining the Paco2 between 33 and 36 mmHg.Each received 2-5 mg haloperidol an hour before induction of anesthesia. Anmsthesia was maintained using 2:1 nitrous oxide and oxygen. DiscussionPentazocine is almost as effective an analgesic as phenoperidine. It causes little respiratory depression even in the presence of medullary failure from neurological damage. It occasionally causes transient respiratory depression reversed by methylphenidate. It causes little additional effect on respiration or circulation when combined with general anesthesia unless halothane is used, when the latter's respiratory depression and circulatory effects are severely aggravated. Minor degrees of depressed respiration (end-tidal CO2 below 42 mmHg) and bradypncea occur consistently. The dose end-tidal CO2 response is not statistically significant but suggests that the response reported in rabbits (Hunter 1968) might also occur in man.Hypertension occasionally develops after large doses (15 mg/kg). This is not due to surgical stimulation or to the effects of CO2 retention or hypoxia. The patient did not show a prior undue sensitivity to the injection of dilute adrenaline solutions.Minor signs of nalorphine-like psychoses can develop (Beaver et al. 1966). This was not seen in the present series. A satisfactory response to respiratory depression occurs with methylphenidate.Pentazocine did not facilitate intermittent positive pressure ventilation of patients in respiratory failure. It has been used to suppress pain and allow the use of hyperventilation for patients with chest and spinal injuries. ConclusionsPentazocine is a potent analgesic suitable for the control of post-operative pain, for analgesic supplement in light general anesthesia, and, combined with haloperidol or droperidol, for neuroleptanalgesia.Respiratory rate seldom falls below 14 and end-tidal CO2 seldom rises above 42 mmHg. Respiratory depression is countered by methylphenidate. Pentazocine occasionally causes hypertension.There is no apparent increase in wound bleeding or tissue engorgement. The ECG is unaltered.It enhances both the respiratory depressant and hypotensive effects of halothane. It does not appear to aggravate respiratory depression due to neurological injury.

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Section: Pentazocine Occasionally Causes Hypertensionmentioning

confidence: 99%

Analgesic Drugs [Abridged]

Hollis

1969

Proceedings of the Royal Society of Medicine

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“…dietetic scale for the mouse; movement of the animal verticallv displaced the platform of the scale causing upward and downward deflections of a pen writing on a moving kymograph. Schallek (106) and Sandberg (107) used a unit (Williamson Development Co., West Concord, Mass.) in which the cage was suspended on a resilient cantilever beam which permits slight sideways motion of the cage in response to the animal's activity.…”

Section: Instrumental Techniquesmentioning

confidence: 99%

Techniques Utilized in the Evaluation of Psychotropic Drugs on Animal Activity

Kinnard

Watzman

1966

Journal of Pharmaceutical Sciences

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“…It has tranquillizing, muscle relaxant, and anticonvulsant actions. In experimental animals its depressant action has been found to act mainly on structures in the limbic system, including the hippocampus, amygdala, and reticular formation (Randall et al, 1961 ;Morillo, 1962 ;Hernandez-Peon et al, 1964;Schallek et al, 1964;Schallek and Kuehn, 1965). It has also been shown that seizures arising in the amygdala in rats can be prevented by the prior administration of this drug (Eidelberg et al, 1965).…”

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confidence: 99%

Use of diazepam in treatment of severe convulsive status epilepticus.

Parsonage¹,

Norris²

1967

BMJ

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Urinary White Cell Excretion-Lindsay et al. MEDICALJOUNAL 85postoperative day, and it is unlikely that this would explain the marked sex difference. SummarySemi-quantitative urinary white cell counts were performed in 198 patients before and after surgery. A significant rise in white cell excretion rates was found in 61% of the females but in only 11 % of the males. The results were confirmed in a further group of patients by means of fully quantitative cell counts, and bacterial counting showed that this pyuria was often associated with significant bacteriuria. The possible significance of these findings is discussed.

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An Action of Mogadon on the Amygdala of the Cat

Cited by 9 publications

References 3 publications

Analgesic Drugs [Abridged]

Analgesic Drugs [Abridged]

Techniques Utilized in the Evaluation of Psychotropic Drugs on Animal Activity

Use of diazepam in treatment of severe convulsive status epilepticus.

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