Use of diazepam in treatment of severe convulsive status epilepticus.

Abstract

Urinary White Cell Excretion-Lindsay et al. MEDICALJOUNAL 85postoperative day, and it is unlikely that this would explain the marked sex difference. SummarySemi-quantitative urinary white cell counts were performed in 198 patients before and after surgery. A significant rise in white cell excretion rates was found in 61% of the females but in only 11 % of the males. The results were confirmed in a further group of patients by means of fully quantitative cell counts, and bacterial counting showed that this pyuria was often associated with significant bacteriuria. The possible significance of these findings is discussed.

Intravenous therapy and EEG monitoring in prolonged seizures.

“…The 'burst-suppression phenomena' reported by Bell (1970) in the EEG of three of his patients never occurred in our studies and may have been due to the larger doses he employed. We did not meet the other complications attributed to diazepam in the literature, such as hypotension and respiratory depression (mentioned by many authors), cardiac arrest (Prensky et al, 1967), hypothermia (Irvine, 1966), abnormal liver function (Parsonage and Norris, 1967), and tonic status epilepticus (Prior et al, 1972).…”

“…In our patients, when a small dose of diazepam was sufficient to control the attacks and stop the discharges in the EEG, there was often a slight increase in fast activity, particularly over the anterior half of the two hemispheres. The 'burst-suppression phenomena' reported by Bell (1970) (Prensky et al, 1967), hypothermia (Irvine, 1966), abnormal liver function (Parsonage and Norris, 1967), and tonic status epilepticus (Prior et al, 1972).…”

Dangers of Treatment of Status Epilepticus with Diazepam

“…However, it has been reported in cases of status epilepticus treated with diazepam. Parsonage and Norris (1967) reported hypotension to have preceded death in one of their nine cases, but did not believe the fall in blood pressure was due to diazepam. Sawyer et al (1968) observed hypotension in one case in which parenteral barbiturate had also been given.…”

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor

“…While DZP is the drug of choice for the treatment of early SE, for acute repetitive seizures and febrile seizure prophylaxis [ 40 , 41 ], it has many side effects such as somnolence, depression, nausea, motor coordination disorder, and dizziness [ 41 ]. Moreover, repeated DZP treatment leads to the development of benzodiazepine tolerance and withdrawal syndrome, making it unsuitable for long-term epilepsy therapy [ 40 , 41 ]. Chronic administration (at least once a day for seven consecutive weeks) of MF1 (1.0 mg/kg, p.o.)…”