Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers

Abstract

We demonstrate a strong enhancement of the antimicrobial action of chlorhexidine which is attributed to the electrostatic adhesion of the cationic nanocarriers on the microbial cell walls which leads to their accumulation and local delivery of chlorhexidine directly on to the microbial cell membrane.

Controlling the Antimicrobial Action of Surface Modified Magnesium Hydroxide Nanoparticles

“…The viability decreases further after six hours and, after one day, it resulted in approximately 97% loss of viability. Past research suggested that the antibacterial effect might be credited to multiple factors: (i) the cellular internalization of NPs where they could potentially interfere with the bacterial DNA and cellular organelles [41,42,43,44,45]; (ii) immediate contacts with the bacterial cell wall [23,24]; and, (iii) the increased local dissolution of metal ions of the nanoscale metal oxide [46,47]. Usually, the antimicrobial impact is dependent on the size of the nanoparticles and a better antimicrobial effect is achieved with smaller nanoparticles [17,48,49,50].…”

Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action

“…Finally, samples were dried at critical point using liquid carbon dioxide. 41,42 The microorganisms before and aer treatment with the CuONPs (bare and HPBA-graed) were imaged using a SEM. Aer incubation with CuONPs, the cells were studied with TEM via the following procedure.…”

Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria

“…[20][21][22][23][24]45 AgNPs has been researched in anti-biofilm treatments due to the silver ions intrinsic antimicrobial property. 25,43 Nanocarriers for antimicrobial agents have also been shown to increase their efficacy against a wide range of microorganisms, including resistant species [26][27][28][29] and deliver drugs specifically to a bacterial target. 35,[42][43][44] This can potentially reduce unwanted drug interaction in healthy tissue and lower general toxicity.…”