Amphotericin B containing microneedle ocular patch for effective treatment of fungal keratitis

Roy, Girdhari; Galigama, Rohini Devi; Thorat, Veda Suresh; Mallela, Lakshmi Sruthi; Roy, Sanhita; Garg, Prashant; Venuganti, Venkata Vamsi Krishna

doi:10.1016/j.ijpharm.2019.118808

Cited by 64 publications

(60 citation statements)

References 30 publications

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“…This concept has produced robust antibody and cellular immune response against lethal challenge. Roy et al fabricated, characterized, and evaluated the ex vivo and in vivo effectiveness of amphotericin B (as free or as a liposomal form) loaded microneedle ocular patch for the treatment of fungal keratitis [ 147 ]. Both ex vivo corneal permeation studies and in vivo (rabbit model) experimentation showed better therapeutic efficiency and hence concluded that microneedle ocular patch can be developed as a less invasive drug delivery device for corneal treatment.…”

Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

262

172

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Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

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Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

262

172

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“…New therapeutic agents and effective administration methods have been investigated to achieve the desired concentration of therapeutic agents in target tissues after ocular exposure to Candida albicans in vivo (Fig. 7a ) 5 . Composed of polyvinyl pyrrolidone and polyvinyl alcohol, the polymer microneedle quickly dissolves within 5 min after being applied to the cornea (water content >81.4%) to deliver the anti-inflammatory drug besifloxacin for the treatment of eye infection (Fig.…”

Section: Micro/nanodevices For Treatmentmentioning

confidence: 99%

“…Composed of polyvinyl pyrrolidone and polyvinyl alcohol, the polymer microneedle quickly dissolves within 5 min after being applied to the cornea (water content >81.4%) to deliver the anti-inflammatory drug besifloxacin for the treatment of eye infection (Fig. 7b ) 5 , 6 . Because the microneedle patch loaded with besifloxacin can completely dissolve within 60 s (ref.…”

Section: Micro/nanodevices For Treatmentmentioning

confidence: 99%

“…As the ability to retain moisture is compromised, the external manifestation often leads to wrinkles. Infectious eye diseases in the latter include keratitis, conjunctivitis retinitis, and blindness 5 , 6 . They can be caused by bacteria, viruses, or fungi.…”

Section: Introductionmentioning

confidence: 99%

“…b Biochemical sensing technology and micro/nanodevices can be used to detect markers in oral saliva and tears, analyze the detected substances, and provide support for the treatment of oral and eye diseases: (i) immunoelectrode for the detection of oral cancer; (ii) platinum nanocluster chemical sensor for measuring the hydrogen peroxide concentration 58 ; (iii) measurement of the glucose concentration in tears for dry eye, glaucoma, keratitis, and other diseases caused by hyperglycemia 110 ; and (iv) contact lens with integrated radio and sensor interface circuit for glucose detection 70 . c Micro/nanodevices can be used for assessment and treatment: (i) microneedle patch for the local administration of drugs to treat oral cancer 105 ; (ii) microgrooves on the surface of the implant for antibacterial activity and mucosal sealing 82 ; (iii) microneedles with drugs applied to the skin surface for eye wrinkle removal; and (iv) microneedle contact lenses to treat eye infections, such as keratitis 5 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

et al. 2021

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Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.

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Self‐Plugging Microneedle (SPM) for Intravitreal Drug Delivery

Lee

Park

et al. 2022

Adv Healthcare Materials

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Intravitreal injection (IVI) is a common technology which is used to treat ophthalmic diseases inside eyeballs by delivering various drugs into the vitreous cavity using hypodermic needles. However, in some cases, there are possible side effects such as ocular tissue damage due to repeated injection or eyeball infection through the hole created during the needle retraction process. The best scenario of IVI is a one-time injection of drugs without needle retraction, keeping the system of the eyeball closed. Microneedles (MNs) have been applied to ocular tissues over 10 years, and no serious side effects on ocular tissue due to MN injection have been reported. Therefore, a self-plugging MN (SPM) is developed to perform intraocular drug delivery and to seal the scleral puncture simultaneously. The SPMs are fabricated by a thermal drawing process and then coated with a polymeric carrier of drugs and a hydrogel-based scleral plugging component. Each coated functional layer is characterized and demonstrated by in vitro and ex vivo experiments. Finally, in vivo tests using a porcine model confirms prompt sealing of SPM and sustained intraocular drug delivery.

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Amphotericin B containing microneedle ocular patch for effective treatment of fungal keratitis

Cited by 64 publications

References 30 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

Self‐Plugging Microneedle (SPM) for Intravitreal Drug Delivery

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