Amphiphilic prodrug-decorated graphene oxide as a multi-functional drug delivery system for efficient cancer therapy

Huang, Chunzhi; Wu, Jilian; Jiang, Wei; Liu, Ruiling; Li, Zhonghao; Luan, Yuxia

doi:10.1016/j.msec.2018.03.017

Cited by 40 publications

(24 citation statements)

References 60 publications

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“…The natural structure of GO destroys covalent bonds. Conversely, non-covalent methods disrupt the internal structure of GO and are therefore more versatile and sensible than covalent methods [142]. Drug release systems can be modulated by stimulus-responsive systems, i.e., specific signals (pH, redox potential, temperature, and light).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Furthermore, PP was conjugated with DOX through disulfide bonding (SS) and mPEG with folic acid (FA). The resulting complex GO/PP-SS-DOX/PEG-FA showed that it has sufficient dispersibility and that it can serve as a stabilizing agent of GO and an active carrier for a target drug delivery [142]. The covalent interactions of the carboxyl groups of GO with the amine group of peptides or polymer surface of rGO lead to a decrease of the content of oxygen, and, on the other hand, GO conductivity was increased in the biological fluid.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Illustration of active tumor-targeting and sufficient redox-sensitive release of GO/PP-SS-DOX/PEG-FA nanohybrids. Reprinted from [142] with permission from Elsevier, copyright 2019. Especially, anticancer drugs, but also drugs from different therapeutic classes, have become a part of GR-based DDSs designed and developed by a number of scientific teams around the word.…”

Section: Figure 11mentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

Plachá

Jampílek

2019

Nanomaterials

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Figure 11mentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

Plachá

Jampílek

2019

Nanomaterials

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“…However, a multiple drug loaded and bioresorbable patch that possesses on-demand antibiosis and anti-inflammatory abilities still has not been achieved, which would have great potential in skin regeneration applications.Herein, to address this issue, we report on an effective and industrially scalable approach to obtain a composite highly biodegradable patch with near infrared (NIR)-triggered antimicrobial and anti-inflammatory properties and cell proliferation ability, so as to promote wound healing through graphene oxide (GO) covalently deposited onto a PCL scaffold. Indeed, GO exhibits multifunctional properties that are useful in drug delivery applications, including enhancement of drug loading owing to the huge surface area and on-demand electrical/near infrared (NIR)-triggered drug release in the site of action [13][14][15][16][17][18]. In addition, GO coating has been proposed as a cell adhesion and proliferation promoter though nonspecific interaction with living cells [19,20].…”

mentioning

confidence: 99%

Near-Infrared, Light-Triggered, On-Demand Anti-inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing

Mauro

Cavallaro

Giammona

2019

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Very recently, significant attention has been focused on the adsorption and cell adhesion properties of graphene oxide (GO), because it is expected to allow high drug loading and controlled drug release, as well as the promotion of cell adhesion and proliferation. This is particularly interesting in the promotion of wound healing, where antibiotics and anti-inflammatories should be locally released for a prolonged time to allow fibroblast proliferation. Here, we designed an implantable patch consisting of poly(caprolactone) electrospun covered with GO, henceforth named GO-PCL, endowed with high ibuprofen (5.85 mg cm −2 ), ketoprofen (0.86 mg cm −2 ), and vancomycin (0.95 mg cm −2 ) loading, used as anti-inflammatory and antibiotic models respectively, and capable of responding to near infrared (NIR)-light stimuli in order to promptly release the payload on-demand beyond three days. Furthermore, we demonstrated the GO is able to promote fibroblast adhesion, a key characteristic to potentially provide wound healing in vivo.supposed to be biocompatible, preserve water content in order to prevent dehydration, and permit oxygenation of the growing tissue without interfering with the wound healing [4,5]. Furthermore, it should display a degradation kinetic comparable to the rate of tissue growth, thus promoting a rapid healing process while it degrades [6].Taking this in mind, engineered polymeric scaffolds have been recently developed to create three-dimensional architecture that can mimic the ECM and allow in situ tissue regeneration. In particular, electrospun patches with micro and nanofiber architectures obtained by electrospinning of polyesters, such as polylactic acid (PLA) and poly(caprolactone) (PCL), yield to scaffolds able to mimic the natural collagen fibers in ECM [2,7]. Because of the crucial role of collagen fibers in maintaining the integrity of skin, electrospun polymeric patches are attracting biomimetic materials potentially able to provide wound healing in vivo [2,6]. Additionally, electrospinning is a mild technique that allows loading of bioactive molecules, such as antibiotics or nonsteroidal anti-inflammatory drugs, to equip the final patch with additional pharmacological effects useful to maintain a suitable environment for skin regeneration [8,9]. Moreover, materials able to release their cargo on-demand have attracted interest from scientists, so as to keep the wound healing processes for a prolonged time and only if required. Thus, plenty of on-demand release biomaterials were prepared involving different mechanisms to trigger drug release, such as stimulus-sensitive hydrogels and polymeric drug loaded nanosponges [10][11][12]. However, a multiple drug loaded and bioresorbable patch that possesses on-demand antibiosis and anti-inflammatory abilities still has not been achieved, which would have great potential in skin regeneration applications.Herein, to address this issue, we report on an effective and industrially scalable approach to obtain a composite highly biodegradable patch with near...

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Carbon‐Based Nanomaterials in Drug Delivery Systems

Chakroborty

Sahoo

2021

Environmental Applications of Carbon Nanomaterials‐Based Devices

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Amphiphilic prodrug-decorated graphene oxide as a multi-functional drug delivery system for efficient cancer therapy

Cited by 40 publications

References 60 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Near-Infrared, Light-Triggered, On-Demand Anti-inflammatories and Antibiotics Release by Graphene Oxide/Elecrospun PCL Patch for Wound Healing

Carbon‐Based Nanomaterials in Drug Delivery Systems

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