Amperometric Immunosensor for Detecting<i>Schistosoma mansoni</i>Antibody

Bojorge-Ramírez, Ninoska I.; Salgado, Andréa Medeiros; Valdman, Belkis

doi:10.1089/adt.2007.082

Cited by 12 publications

(11 citation statements)

References 38 publications

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“…The electrode surface was oxidized and treated with APTES to form amino groups which were further activated with GA to immobilize apyrase protein. Once the detection antibody (HRP-IgG) was added, determination of anti-apyrase was performed by amperometry in the presence of H 2 O 2 as the enzyme substrate and 3,3,5,5-tetramethylbenzidine (TMB) redox mediator [77].…”

Section: Electrochemical Affinity Biosensors For Detection Of Ntds Camentioning

confidence: 99%

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

2017

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Rapid and reliable diagnosis of viral infections and tropical diseases and timely initiation of appropriate treatment are essential for their successful clinical management. This Review summarizes some basic concepts regarding the main viral infection and tropical diseases to which society is facing today and the conventional methods available for their detection. The tremendous potential offered by electrochemical affinity biosensors to address this important challenge, meeting the required demands for viral infections and tropical diseases diagnosis, is clearly stated by discussing challenges, opportunities, implementation, and application of selected examples focused on the determination of specific biomarkers of different molecular (genetic, regulatory, and functional) levels. The highlighted approaches demonstrate the use of a plethora of specific receptors and assay formats and a great diversity of attractive electrochemical approaches in this rapidly advancing and highly interesting field.

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Section: Electrochemical Affinity Biosensors For Detection Of Ntds Camentioning

confidence: 99%

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

2017

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“…126 The function of epoxy resin is to harden the carbon powder of the manufactured electrode. This strategy of surface modification renders a suitable platform for protein immobilization on protein arrays and immunosensors.…”

Section: Schistosomiasismentioning

confidence: 99%

Biosensors as rapid diagnostic tests for tropical diseases

Teles

Tavira

Fonseca

2010

Critical Reviews in Clinical Laboratory Sciences

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Effective diagnosis of infectious pathogens is essential for disease identification and subsequent adequate treatment, to prevent drug resistance and to adopt suitable public health interventions for the prevention and control of epidemic outbreaks. Particular situations under which medical diagnostics operate in tropical environments make the use of new easy-to-use diagnostic tools the preferred (or even unique) option. These diagnostic tests and devices, usually based on biosensing methods, are being increasingly exploited as promising alternatives to classical, "heavy" lab instrumentation for clinical diagnosis, allowing simple, inexpensive and point-of-care testing. However, in many developing countries the lack of accessibility and affordability for many commercial diagnostic tests remains a major cause of high disease burden in such regions. We present a comprehensive overview about the problems of conventional medical diagnosis of infectious pathologies in tropical regions, while pointing out new methods and analytical tools for in-the-field and decentralized diagnosis of current major infectious tropical diseases. The review includes not only biosensor-based rapid diagnostic tests approved by regulatory entities and already commercialized, but also those at the early stages of research.

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“…In this same line, our research group proposed an immunosensor for detecting the antibody anti-apyrase of S. mansoni based on rigid composite materials, containing graphite powder and epoxy resins, A surface modification strategy for the use of oxidized graphite in the detection of antibodyantigen interaction was developed. This modification strategy is based on silanization of a conductive composite (Bojorge et al, 2007).…”

Section: Ii) Techniques For Biomolecule Immobilizationmentioning

confidence: 99%

The evolution and developments of immunosensors for health and environmental monitoring: problems and perspectives

Ramirez

Salgado

Valdman

2009

Braz. J. Chem. Eng.

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This paper is an overview of the recent developments in immunosensors, which have attracted considerable attention. Immunosensors can play an important role in the improvement of public health by providing applications for which rapid detection, high sensitivity, and specificity are important, in areas such as clinical chemistry, food quality, and environmental monitoring. This review focuses on the current research in immunoassay methods based on electrochemical detection for the analysis of environmental samples or medical diagnostic methods with emphasis on recent advances, challenges and trends. Technological aspects in the development of immunosensors such as kinetics of biomolecular interaction, techniques of immobilization, simplification of assay procedures, immunointeration and catalytic studies and system miniaturization are presented

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Amperometric Immunosensor for DetectingSchistosoma mansoniAntibody

Cited by 12 publications

References 38 publications

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

Biosensors as rapid diagnostic tests for tropical diseases

The evolution and developments of immunosensors for health and environmental monitoring: problems and perspectives

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