Amniotic membrane graft to reconstruct divided nevi of eyelids

Abstract

Two patients with congenital divided nevi of the eyelids presented with chief symptoms of cosmetic blemish (n=2) and epiphora (n=1). All the lesions were surgically excised with histological free margins and amniotic membrane graft (AMG) was used to cover the mucosal and eyelid marginal defects. Caruncular and punctal involvement was managed with complete excision and monocanalicular stent insertion to prevent punctal stenosis. AMG provided an adequate scaffold for conjunctival regenesis and anatomic continuity was found within 6 weeks in both patients. None of them had any residual pigmentation or disease recurrence after a follow-up of more than 2.5 years. Local absence of eyelashes was the only drawback which patients masked with modern artificial eyelashes or make-up. This novel utility of AMG illustrates effective conjunctival regenesis and maintenance of mucocutaneous junction functionality.

Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids

“…[ 9 ] The MCJ is an important functional part of eyelid margin which is in constant contact with the eyeball. [ 10 ] Hence, the reconstruction of both skin and MCJ is a challenge in kissing nevi of eyelids. Conservative management options (cryo, laser, dermabrasion) have been shown to provide inferior cosmetic and functional outcomes.…”

“…Conservative management options (cryo, laser, dermabrasion) have been shown to provide inferior cosmetic and functional outcomes. [ 1 4 10 ]…”

“…As AMG supports the conjunctival epithelial cell division and growth, the idea of its application is helpful in indispensable conjunctival mucosal reconstruction. [ 10 ] Moreover, the antibacterial, anti-inflammatory, and antiapoptotic property along with its free availability make AMG the graft of choice for the reconstruction of eyelid MCJ.…”

Case series: The use of a dehydrated human amnion/chorion membrane allograft to enhance healing in the repair of lower eyelid defects after Mohs micrographic surgery

“…Human amniotic membrane has been used clinically in a variety of applications for more than 100 years, but there are limited data showing the utility in the repair of cutaneous eyelid surgical defects. 5 Amniotic membrane has been identified as a potent facilitator of wound healing in a variety of circumstances, including lower extremity ulcers, conjunctival reconstruction, burns, gynecologic surgery, and orthopedic surgery. 6 , 7 , 8 , 9 , 10 , 11 , 12 Key features of amniotic membrane include an immunologically privileged state, a reservoir of multiple growth factors involved with tissue regeneration, and modulation of inflammatory processes.…”

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

“…Various grafts have been used, including cryopreserved, ultra-thick, fresh, and dehydrated amniotic membrane. 13,[57][58][59][60][61][62][63][64] Mainly, case reports and case series have been published. Patient populations have included those with conjunctival melanoma with eyelid involvement, orbital sebaceous carcinoma involving the lower eyelid, squamous cell and basal cell carcinoma, and superficial lower eyelid defects after Mohs surgery.…”