Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.11.052 View full text
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Manuel Ventura, Brent Murphy, Wolfgang Goetzinger

Abstract: Supercritical fluid chromatography is routinely utilized by analytical separations groups in the pharmaceutical industry to efficiently handle separations for discovery medicinal chemistry purposes. Purifications are performed on samples ranging from a few milligrams up to hundreds of grams. Basic additives dissolved into the liquid component of the SFC mobile phase are commonly used to improve peak shape and efficiency in achiral and chiral separations. While for purposes of analysis there is minimal conseque…

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