Amino Acid-Induced Thermogenesis Reduces Hypothermia During Anesthesia and Shortens Hospital Stay

Fructose Administration Increases Intraoperative Core Temperature by Augmenting Both Metabolic Rate and the Vasoconstriction Threshold

“…14,15 It is well established, for example, that amino acid infusions induce perioperative thermogenesis and help prevent hypothermia. 16,17 But interestingly, amino acid infusions also slightly increase all major autonomic thermoregulatory defense thresholds and resting core temperature. 18 Amino acids thus have both metabolic and thermoregulatory properties that help maintain intraoperative normothermia.…”

Effect of Amino Acid Infusion on Central Thermoregulatory Control in Humans

“…10 As might thus be expected, thermogenesis associated with amino acid infusions have been shown in numerous studies to help preserve intraoperative core temperature 5,11 and to moderate complications associated with hypothermia. [12][13][14] An interesting consequence of the hypermetabolism associated with protein ingestion or amino acid infusion is that each increases core temperature, even when thermoregulation remains intact (i.e., in unanesthetized volunteers) 8,9 While hyperthermia might seem a logical consequence of hypermetabolism, this is actually the case only in the absence of effective thermoregulatory control (e.g., during anesthesia) because thermoregulatory defenses normally maintain core temperature despite alterations in heat production or heat loss. A single light cotton blanket, for example, reduces heat loss by ≈30% 15 which improves systemic heat balance more than the hypermetabolism associated with protein or amino acid administration.…”

Preoperative carbohydrate-rich beverage reduces hypothermia during general anesthesia in rats

“…However, the thermic effect in subjects under general anesthesia was found to be fivefold higher than that in awake individuals [14]. Mizobe et al [11] reported that the metabolic rate is increased by approximately 20% during anesthesia due to the administration of fructose.…”