Effect of Amino Acid Infusion on Central Thermoregulatory Control in Humans

Nakajima, Yasufumi; Takamata, Akira; Matsukawa, Takashi; Sessler, Daniel I.; Kitamura, Yoshihiro; Ueno, Hiroshi; Tanaka, Yoshifumi; Mizobe, Toshiki

doi:10.1097/00000542-200403000-00025

Cited by 42 publications

(24 citation statements)

References 35 publications

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“…Most probably there is a combination of thermoregulatory and molecular factors. Proteins and amino acids may have a pyrogen-like influence and reset the set point in the awake state (16,17), possibly via a second messenger. Body oxidative metabolism keeps the body core temperature constant and prevents hypothermia in the awake state (18).…”

Section: Discussionmentioning

confidence: 99%

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Imoto¹,

Yokoyama²,

Suwa³

et al. 2010

J Nutr Sci Vitaminol

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SummaryWe hypothesized that, with oral or intestinal administration of amino acids (AA), we may reduce hypothermia during general anesthesia as effectively as with intravenous AA. We, therefore, examined the effect of bolus oral and continuous intestinal AA in preventing hypothermia in rats. Male Wistar rats were anesthetized with sevoflurane for induction and with propofol for maintenance. In the first experiment, 30 min before anesthesia, rats received one bolus 42 mL/kg of AA solution

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Section: Discussionmentioning

confidence: 99%

Bolus Oral or Continuous Intestinal Amino Acids Reduce Hypothermia during Anesthesia in Rats

Imoto¹,

Yokoyama²,

Suwa³

et al. 2010

J Nutr Sci Vitaminol

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show abstract

“…An explanation might be that any enhanced thermogenesis which increases oxidative metabolism leads to a concomitantly increased production of oxygen radicals and thus affects both redox and temperature homeostasis. The observation that in humans an amino acid infusion which increases metabolic rate causes a rise of the thermoregulatory setpoint supports this concept (Nakajima et al 2004).…”

Section: Fevermentioning

confidence: 94%

Role of afferent pathways of heat and cold in body temperature regulation

et al. 2004

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The detection of surface and internal temperatures is achieved by axons terminating at lamina I of the spinal dorsal horn, otherwise approached only by nociceptive afferents. Recent advances in thermal physiology research have disclosed that temperature-sensitive ion channels belonging to the "transient receptor potential" family exist in the peripheral sensory neurons and in the brain. Thermosensory, nociceptive and polymodal afferents project to different thalamic nuclei, and specific pathways to the insular cortex evoke the conscious experience of thermal sensation. The posterior insular region represents discriminative thermal sensation, while the largest correlation with subjective ratings of temperature is located in the orbitofrontal and anterior insular cortex. The insular cortex forms an integrative part of the limbic system and is closely tied with the hypothalamus, the amygdala, the anterior cingulate cortex and the orbitofrontal cortex and emerges as the main coordinator of behavioral, autonomic and endocrine responses to both non-noxious and noxious thermal stimuli. The firing rate of warm and cold receptors is not altered by pyrogens. A strong correlation between the onset of fever and production of superoxide by macrophages following the injection of pyrogens implicates reactive oxygen species as elicitors of fever, a hypothesis strengthened by the observation that oxygen radical scavengers or thiol reductants act as antipyretics. Oxidative stress appears to be sensed by the brain and a likely structure for its detection may be the redox-sensitive site of the N-methyl-D-aspartate (NMDA) receptor for glutamate, in that oxidation of this site causes fever while its reduction lowers body temperature, effects which are abrogated by specific NMDA receptor blockers.

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“…AAs is likely to enhance the quality of patient care and improve cost-effectiveness [4][5][6]. AA infusion appears to be a useful new thermoregulatory strategy for preventing hypothermia during surgery.…”

mentioning

confidence: 99%

“…According to recent reports, AAs induce an increase in energy expenditure that may be explained by several mechanisms, including an increase in the energy cost of glucose storage [7], increased anabolism [8,9], an infl uence on central thermoregulatory mechanisms [5], and hormonal regulation of mitochondrial energy production [10]. It has been reported that AA infusion stimulates the release of metabolic hormones such as insulin, cortisol, and glucagon [9], suggesting that hormonal regulation may play a part in energy expenditure.…”

mentioning

confidence: 99%