Fructose Administration Increases Intraoperative Core Temperature by Augmenting Both Metabolic Rate and the Vasoconstriction Threshold

Mizobe, Toshiki; Nakajima, Yasufumi; Ueno, Hiroshi; Sessler, Daniel I.

doi:10.1097/00000542-200606000-00005

Cited by 39 publications

(24 citation statements)

References 29 publications

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“…5 Interestingly, Mizobe et al reported that infusion of fructose for fasting preoperative surgical patients led to an increase in core temperature compared with those receiving normal saline infusion. 21 This was achieved by increasing oxygen consumption and metabolic rate. The authors postulated that fructose provided metabolic substrate for thermogenesis.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between body temperature and serum lactate levels in hip fracture patients?

Murtuza

Farrier

Venkatesan

et al. 2015

annals

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INTRODUCTION Hyperlactataemia is associated with adverse outcomes in trauma cases. It is thought to be the result of anaerobic respiration during hypoperfusion. This produces much less energy than complete aerobic glycolysis. Low body temperature in the injured patient carries an equally poor prognosis. Significant amounts of energy are expended in maintaining euthermia. Consequently, there may be a link between lactate levels and dysthermia. Hyperlactataemia may be indicative of inefficient energy production and therefore insufficient energy to maintain euthermia. Alternatively, significant amounts of available oxygen may be sequestered in thermoregulation, resulting in anaerobic respiration and lactate production.Our study investigated whether there is an association between lactate levels and admission body temperature in hip fracture patients. Furthermore, it looked at whether there is a difference in the mean lactate levels between hip fracture patients with low (<36.5°C), normal (36.5-37.5°C) and high (>37.5°C) body temperature on admission, and for patients who have low body temperature, whether there is a progressive rise in serum lactate levels as body temperature falls. METHODS The admission temperature and serum lactate of 1,162 patients presenting with hip fracture were recorded. Patients were divided into the euthermic (body temperature 36.5-37.5°C), the pyrexial (>37.5°C) and those with low body temperature (<36.5°C). Admission lactate and body temperature were compared. RESULTS There was a significant difference in age between the three body temperature groups (p=0.007). The pyrexial cohort was younger than the low body temperature group (mean: 78 vs 82 years). Those with low body temperature had a higher mean lactate level than the euthermic (2.2mmol/l vs 2.0mmol/l, p=0.03). However, there was no progressive rise in serum lactate level as admission temperature fell. CONCLUSIONS The findings suggest that in hip fracture patients, the body attempts initially to maintain euthermia, incurring an oxygen debt. This would explain the difference in lactate level between the low body temperature and euthermic cohorts. The fact that there is no correlation with the degree of temperature depression and lactate levels indicates that the body does not fuel thermohomeostasis indefinitely with oxygen. Instead, in part, it abandons thermoregulatory mechanisms. Consequently, in this population, active rewarming may be indicated rather than depending on patients' own thermogenic ability.

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Section: Discussionmentioning

confidence: 99%

Is there an association between body temperature and serum lactate levels in hip fracture patients?

Murtuza

Farrier

Venkatesan

et al. 2015

annals

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“…Similarly, studies in humans have also shown that fructose stimulates de novo lipogenesis and blocks fatty acid oxidation in the liver (13, 63–66). Acutely (hours) fructose stimulates thermogenesis and metabolic rate (67, 68), but chronically fructose (days to weeks) has been shown to reduce resting energy expenditure (66). The mechanisms for these effects are discussed below, but it is readily evident how these processes could lead to fat accumulation in the liver and elsewhere.…”

Section: Fructose Effect On Lipogenesis and Fat Oxidationmentioning

confidence: 99%

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

Jensen

Abdelmalek

Sullivan

et al. 2018

Journal of Hepatology

703

490

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Nonalcoholic Fatty Liver Disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result from overnutrition and sedentary lifestyle, recent evidence suggests that diets high in sugar (from sucrose and/or high fructose corn syrup (HFCS)) not only increases the risk for NAFLD, but also, nonalcoholic steatohepatitis (NASH). Here we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increased lipogenesis and impaired fat oxidation. Recent evidence suggests that the predisposition to fatty liver is linked with metabolism of fructose by fructokinase C, resulting in ATP consumption, nucleotide turnover and uric acid generation that mediate fat accumulation. Alterations in gut permeability, microbiome, and associated endotoxemia contributes to the risk of NAFLD and NASH. Early clinical studies suggest that reducing sugary beverages and total fructose intake, especially from added sugars, may have a significant benefit on reducing hepatic fat accumulation. We suggest larger, more definitive trials to determine if lowering sugar/HFCS intake, and/or blocking uric acid generation, may help reduce NAFLD and its downstream complications of cirrhosis and chronic liver disease.

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“…We also reported that preoperative oral amino acid intake contributes to the prevention of intraoperative hypothermia under general anesthesia in rats [10]. Mizobe et al [11] reported that preoperative fructose infusion helped to maintain normothermia by augmenting metabolic heat production and increasing the vasoconstriction threshold.…”

Section: Introductionmentioning

confidence: 59%

“…However, the thermic effect in subjects under general anesthesia was found to be fivefold higher than that in awake individuals [14]. Mizobe et al [11] reported that the metabolic rate is increased by approximately 20% during anesthesia due to the administration of fructose. However, the mechanism underlying this increase has not been elucidated.…”

Section: Discussionmentioning

confidence: 96%

Preoperative carbohydrate-rich beverage reduces hypothermia during general anesthesia in rats

et al. 2011

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Fructose Administration Increases Intraoperative Core Temperature by Augmenting Both Metabolic Rate and the Vasoconstriction Threshold

Abstract: Background-We tested the hypothesis that intravenous fructose ameliorates intraoperative hypothermia both by increasing metabolic rate and the vasoconstriction threshold (triggering core temperature)

Cited by 39 publications

References 29 publications

Is there an association between body temperature and serum lactate levels in hip fracture patients?

Is there an association between body temperature and serum lactate levels in hip fracture patients?

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

Preoperative carbohydrate-rich beverage reduces hypothermia during general anesthesia in rats

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