Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: Solubilization, in vitro release and biological evaluation

Dutta, Pranabesh; Dey, Joykrishna; Perumal, Venkatesan; Mandal, Mahitosh

doi:10.1016/j.ijpharm.2011.01.041

Cited by 21 publications

(9 citation statements)

References 51 publications

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“…The hemocompatibility test was done to study the disruption of red blood cells in the presence of the gel leachate. The presence of noncompatible leachant into a leachate resulted in the disruption of the red blood cells and stimulated the release of hemoglobin pigment into the solution 69. The amount of hemoglobin released was then measured spectrophotometrically.…”

Section: Resultsmentioning

confidence: 99%

Sunflower‐oil‐based lecithin organogels as matrices for controlled drug delivery

Satapathy

Biswas

Behera

et al. 2012

J of Applied Polymer Sci

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In this study, we dealt with the development of lecithin‐based organogels using sunflower oil as the apolar phase. Metronidazole (MZ) was used as a model drug. The organogels were characterized by microscopy (light and phase contrast), Fourier transform infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, rheology, alternating‐current impedance, hemocompatibility, antimicrobial analysis, and in vitro drug release. Microscopic analysis revealed the presence of spherical reverse micellar structures. There was an increase in the intermolecular hydrogen bonding among the gel components and crystallinity as MZ was incorporated into the organogels. The pH of the gel indicated that the gel may be nonirritant in nature and was hemocompatible. The release of MZ from the organogels followed Higuchi kinetics and was governed by anomalous or non‐Fickian transport. The drug‐loaded organogels showed antimicrobial activity against Bacillus subtilis, a Gram‐positive bacteria. The preliminary results indicate that the developed organogel may be used as drug‐delivery vehicle. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Section: Resultsmentioning

confidence: 99%

Sunflower‐oil‐based lecithin organogels as matrices for controlled drug delivery

Satapathy

Biswas

Behera

et al. 2012

J of Applied Polymer Sci

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“…Soy-gels formulated with Span 40 and Span 60 are expected to spread uniformly over the affected area of skin on being extruded without loss of structural integrity. The formulations may be regarded as hemocompatible as percentage hemolysis was <5% [34].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

Mukherjee¹,

Ash²,

Biswas³

et al. 2019

Asian J Pharm Clin Res

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Objective: Hydrogels or emulgels are recommended for topical application to elicit a local effect. However, they suffer from stability problems. The present study deals with the formulation and comparison of thermally stable soybean oil-based novel topical organogels (soy-gels) using two different gelators (Span 40 and Span 60) for controlled drug delivery. Methods: Soy-gels (8 batches) were developed with Span 40 and Span 60 by solid fiber mechanism and characterized for viscosity, gelation kinetics behavior, gel-sol transition parameters, drug content, in vitro drug release pattern, and changes occurring during accelerated thermal stability studies. Results: Fourier transformed infrared spectroscopic confirmed the compatibility among the organogel components and paracetamol. The formulations exhibited skin and hemocompatibility. The viscosity of Span 60 based soy-gels was found to be approximately 10 times higher than those of Span 40 based formulations. In comparison to Span 40, Span 60 induced faster gelation (3–6 min) of soybean oil at lower concentration (16% w/v) forming less flexible but thermally more stable soy-gels demonstrating higher Tg values. Higher flexibility and lower viscosity accounted for improved drug diffusion (both Fickian and non-Fickian) from Span 40 gels of varying concentrations in pH 5.8. However, zero-order drug release was observed in organogel with 18% w/v Span 40 only and all Span 60-based formulations except the one with 22% w/v Span 60. Non-Fickian drug diffusion occurred from Span 60 based soy-gels. A gradual increase in gelation time was observed until five cycles of freeze-thaw. Conclusion: Therefore, the choice of organogelator governs the rheological, thermal, and drug diffusion properties of soy-gels intended for topical application.

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“…The results suggested that all the organogel samples were highly hemocompatible (% hemolysis <5%) and may be regarded as biocompatible in nature, [25,51,52] …”

Section: Ph Measurementmentioning

confidence: 98%

“…Goat blood was used for the study and the experiment was carried out as described elsewhere. [3,25] The % hemolysis was calculated as per the following formula:…”

Section: Hemocompatibility Studiesmentioning

confidence: 99%

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

Satapathy

Sagiri

Pal

et al. 2013

Designed Monomers and Polymers

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The present study deals with the development and characterization of sorbitan monopalmitate (SM) organogels using mustard oil (MO) and groundnut oil (GO) as the apolar phase. In both the cases, the organogels containing ≥ 20% (w/w) SM were found to be stable for prolonged period. The microscopic studies showed the presence of aggregates of tubular shaped gelator fibers in the gel architecture. Fourier transform infrared spectroscopy indicated formation of intermolecular hydrogen bonding amongst the oil and gelator molecules. Differential scanning colorimetry studies indicated that the thermal stability of GO organogels was found to be more than the MO organogels. Gels showed pseudoplastic flow, with shear thinning and thixotropic behavior. The drug release from the organogels followed Higuchian kinetics with non-Fickian diffusion. The pH values of organogels were found to be near the human skin pH and highly hemocompatible. Metronidazole loaded organogels have shown good antimicrobial activity against Bacillus subtilis. Based on the preliminary studies, the developed organogels may be tried as drug carriers.

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Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: Solubilization, in vitro release and biological evaluation

Cited by 21 publications

References 51 publications

Sunflower‐oil‐based lecithin organogels as matrices for controlled drug delivery

Sunflower‐oil‐based lecithin organogels as matrices for controlled drug delivery

Comparative Study of Span 40 and Span 60 Based Soy-Gels for Topical Drug Delivery

Development of mustard oil- and groundnut oil-based span 40 organogels as matrices for controlled drug delivery

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