Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Lai, Jonathan; Blanas, Nick; Higgins, Kevin; Klieb, Hagen

doi:10.1016/j.joms.2011.09.012

Cited by 34 publications

(39 citation statements)

References 34 publications

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“…On imaging, the tumor is a destructive expansile radiolucent jaw mass with ill-defined borders. Interestingly, about half of these tumors arise in a recurrence of a previous AF and the mean age of AF is about 10 years younger (14.6 years) than for AFS [37][38][39]. ARS is considered a locally aggressive neoplasm with a low incidence of metastasis (4 %).…”

Section: Ameloblastic Fibrosarcoma (Afs)mentioning

confidence: 99%

Malignant Odontogenic Tumors: An Update on Selected Tumors

Richardson

Müller

2014

Head and Neck Pathol

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This is an update on selected odontogenic malignancies. The article deals with aspects of recognized odontogenic carcinomas, odontogenic sarcoma and a yet unrecognized entity, sclerosing odontogenic carcinoma. Odontogenic malignancies are exceedingly rare, complicating a thorough understanding of the biologic behavior, reproducible standardized diagnostic criteria, appropriate classification and clinical management. Without the knowledge of the tumor's biologic behavior, adequate clinical management is difficult and patient outcomes uncertain. The histopathologic features are emphasized as well as the more recent biomarker findings. These recent advances may facilitate further understanding of this group of malignancies and provide useful stratification to guide patient management.

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Section: Ameloblastic Fibrosarcoma (Afs)mentioning

confidence: 99%

Malignant Odontogenic Tumors: An Update on Selected Tumors

Richardson

Müller

2014

Head and Neck Pathol

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“…AFS is the most common of them (66,(114)(115)(116)(117). In Brazilian series, the reported frequency of AFS is up to 1.0% of OTs (3,(117)(118)(119)(120) The WHO's odontogenic tumor classification describes AFS as being of primary (de novo lesion) and secondary (from benign AF) types (1,4,5). Because of the secondary types (88), initial diagnosis of a malignant phenotype is not always easy.…”

Section: Discussionmentioning

confidence: 99%

“…Results obtained from several papers (4,5,69,79,82,88,89,113) revealed that Ki-67 was overexpressed (highly diffuse positivity) in the malignant mesenchymal portion of AFS, compared with AF. When Ki-67 was quantified, positivity rates ranged from 13.5% to 60.0% for the malignant mesenchymal component.…”

Section: Discussionmentioning

confidence: 99%

“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

“…It is regarded as the malignant counterpart of ameloblastic fibroma (AF). However, most cases were diagnosed as primary malignant processes (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

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Ameloblastic Fibrosarcoma in Pregnancy: an Unreported Entity!

Maji

Ghosh

2018

Indian J Surg Oncol

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AFS is a rare tumor of odontogenic origin. Less than 100 cases have been reported so far in the literature. Due to its extreme rarity, we do not have clear management guidelines at present. The entire clinical spectrum and natural history of this uncommon malignancy is unknown. Most of the cases present with facial swelling along with varying degrees of oral signs and symptoms. AFS has higher incidence in male and common in third decade of life. However, presentation in female can be unique and may have a different course and outcome then what is known to us. The association of pregnancy and AFS is interesting and has hardly been emphasized before. Pregnancy can dramatically boost the growth of this tumor leading to impending airway obstruction or fatal hemorrhage. We report a case of an 18-year-old pregnant female who presented with rapidly enlarging bleeding mandibular mass and respiratory distress and present the challenges in its surgical management along with it longterm outcome on follow-up. We also discuss and explore the probable role of AFS in context of pregnancy and its oncological outcome.

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Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Cited by 34 publications

References 34 publications

Malignant Odontogenic Tumors: An Update on Selected Tumors

Malignant Odontogenic Tumors: An Update on Selected Tumors

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Ameloblastic Fibrosarcoma in Pregnancy: an Unreported Entity!

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